ID G4CX76_9ACTN Unreviewed; 483 AA.
AC G4CX76;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=Catalase KatA {ECO:0000313|EMBL:EGY77590.1};
DE EC=1.11.1.6 {ECO:0000313|EMBL:EGY77590.1};
GN Name=katA {ECO:0000313|EMBL:EGY77590.1};
GN ORFNames=HMPREF9153_1133 {ECO:0000313|EMBL:EGY77590.1};
OS Cutibacterium avidum ATCC 25577.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Cutibacterium.
OX NCBI_TaxID=997355 {ECO:0000313|EMBL:EGY77590.1, ECO:0000313|Proteomes:UP000005332};
RN [1] {ECO:0000313|EMBL:EGY77590.1, ECO:0000313|Proteomes:UP000005332}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25577 {ECO:0000313|EMBL:EGY77590.1,
RC ECO:0000313|Proteomes:UP000005332};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|PIRSR:PIRSR038928-2};
CC -!- SIMILARITY: Belongs to the catalase family.
CC {ECO:0000256|ARBA:ARBA00005329}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGY77590.1}.
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DR EMBL; AGBA01000013; EGY77590.1; -; Genomic_DNA.
DR RefSeq; WP_004810220.1; NZ_JH165054.1.
DR AlphaFoldDB; G4CX76; -.
DR PATRIC; fig|997355.3.peg.1113; -.
DR HOGENOM; CLU_010645_2_0_11; -.
DR Proteomes; UP000005332; Unassembled WGS sequence.
DR GO; GO:0004096; F:catalase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 2.40.180.10; Catalase core domain; 1.
DR InterPro; IPR018028; Catalase.
DR InterPro; IPR024708; Catalase_AS.
DR InterPro; IPR024711; Catalase_clade1/3.
DR InterPro; IPR011614; Catalase_core.
DR InterPro; IPR010582; Catalase_immune_responsive.
DR InterPro; IPR020835; Catalase_sf.
DR PANTHER; PTHR11465; CATALASE; 1.
DR PANTHER; PTHR11465:SF9; CATALASE; 1.
DR Pfam; PF00199; Catalase; 1.
DR Pfam; PF06628; Catalase-rel; 1.
DR PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR PRINTS; PR00067; CATALASE.
DR SMART; SM01060; Catalase; 1.
DR SUPFAM; SSF56634; Heme-dependent catalase-like; 1.
DR PROSITE; PS00438; CATALASE_2; 1.
DR PROSITE; PS51402; CATALASE_3; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR038928-2};
KW Hydrogen peroxide {ECO:0000256|ARBA:ARBA00023324};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR038928-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR038928-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EGY77590.1};
KW Peroxidase {ECO:0000256|ARBA:ARBA00022559, ECO:0000313|EMBL:EGY77590.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005332}.
FT DOMAIN 10..392
FT /note="Catalase core"
FT /evidence="ECO:0000259|SMART:SM01060"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 57
FT /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
FT ACT_SITE 129
FT /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
FT BINDING 339
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR038928-2"
SQ SEQUENCE 483 AA; 54411 MW; CE352176FDC53129 CRC64;
MPIDPSKPST NTNGSPAPSD EYSLTVGADG PVLLHDAHLI DTLAHFNREN IPERKPHAKG
SGAFGHFETT ADVSEYTKAG FLQKGKETPM LARFSTVAGE LGSPDTWRDV RGFSLKFYTD
EGNFDMVGNN TPVFFMRDPM KFPHFIRSQK RLPNSGLRSP NMMYDYWSLS PESAHQVAYL
MGPRGIPLSY RTMNGYSSHT YSWVNAEGKI TWVKYHFISD QGVHTMTADQ AKAVVGDHPD
LHREDLFNHI ADGDHPSWTV KVQLMPYDDA KDYRFNPFDI TKVWPHKDYP LHTIGRFTLD
RNPENFFAEI EQAAFSPSNT VEGTGLSPDR MLLSRAFAYN DAARNRLGVN YEQLPVNRPT
VATNQYTFDG QMTYEHAGSA PTYAPNSYGR DHATGYRAGS EVTWETDGEL VRAAQTLHSE
DDDFGQAHTL VHDVFSEQER DELVETLVDL LTNFDMEEPV IGNTLTYWRN IDAGIADRVE
STM
//
