ID G4CZQ1_9ACTN Unreviewed; 856 AA.
AC G4CZQ1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Beta-mannosidase B {ECO:0000256|ARBA:ARBA00041069};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
DE AltName: Full=Mannanase B {ECO:0000256|ARBA:ARBA00041614};
GN ORFNames=HMPREF9153_1923 {ECO:0000313|EMBL:EGY76970.1};
OS Cutibacterium avidum ATCC 25577.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Cutibacterium.
OX NCBI_TaxID=997355 {ECO:0000313|EMBL:EGY76970.1, ECO:0000313|Proteomes:UP000005332};
RN [1] {ECO:0000313|EMBL:EGY76970.1, ECO:0000313|Proteomes:UP000005332}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25577 {ECO:0000313|EMBL:EGY76970.1,
RC ECO:0000313|Proteomes:UP000005332};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- PATHWAY: Glycan metabolism; N-glycan degradation.
CC {ECO:0000256|ARBA:ARBA00004740}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family. Beta-
CC mannosidase B subfamily. {ECO:0000256|ARBA:ARBA00038429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGY76970.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGBA01000015; EGY76970.1; -; Genomic_DNA.
DR RefSeq; WP_004811527.1; NZ_JH165054.1.
DR AlphaFoldDB; G4CZQ1; -.
DR PATRIC; fig|997355.3.peg.1893; -.
DR HOGENOM; CLU_005015_3_2_11; -.
DR Proteomes; UP000005332; Unassembled WGS sequence.
DR GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProt.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041447; Mannosidase_ig.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF17786; Mannosidase_ig; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000005332}.
FT DOMAIN 221..316
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 691..745
FT /note="Mannosidase Ig/CBM-like"
FT /evidence="ECO:0000259|Pfam:PF17786"
SQ SEQUENCE 856 AA; 94209 MW; FAB45A5C59C93111 CRC64;
MSALFQLTSS NPRVVDPVEL AAEDCEWIDA VVPGGVHESL ISAGVIDHPY LRNHEKDCRW
VEDCAWWYRG TLAVPSGEDP LVLSLTGVDT VADIWVDGEH VGRHASQYRP FSTILPPIDG
DQAEVLIRFA PPLDGLTEPP ATRAMVNAVS DFLNATAPQE LDTEPGAGIL TLDLAATRCR
KGMFSWGWDF APRVPSIGLT GTVELSRRAP VELTHRVETV SISGDSASVN VIVAVTHHDG
PRPLDVDVSL TSPTGEHTGG HARIRDGVAT VELHIEHPQL WWTHDLGEPS LYRLEVNAHD
KDANTIATES GTAGIRTIEV DHSPDPEDPE YDGPARHFRF ILNGVPVFAR GANLVPQSML
VGSVTPEQDR DLVRACRNGG MTMVRVWGGG IYASDTFMDA CDENGILVWH DFMFACIDYP
GDDQEFMSEV RTEADYQTRR LASHPSLALW AGGNEVQAMH QAVWNNLNPG QWGSEIFDEI
LPAAVRRNCP TVDYWANSPA TDADTDPRVN GTGVGDRHAW EVWHGADVGA GTHEDYASPA
EAMHFHRYRH DTGRFISEFG IHASADLPTL ARWLGRDHLK LDDPVLIARN KDTPKAKGMA
LLEYEVGRPT SLQSYVTSTQ VVQAEGLKYG IEHYRRRWPH CAGTLVWQLN EPWPGMTWSL
LDHDLGAKPG YYAAARAFAP ALPILRLTDE ALELWVSNVQ PTRVTDTVTV SIEGFNGTVE
QTHEVKVSVP ASTSEKVWSV PRAQVPVNGG HYVWVEGAML PSNRLFLTHI ADLVLPDPEL
DVEVTPTGTT TAKVRVRASK FAYFVRVLTP WPGVRADVSA LDVRPGKTVV MNLEGLPGGF
NPDEITVRHF LDDVKR
//
