ID G4E3G1_9GAMM Unreviewed; 726 AA.
AC G4E3G1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN ORFNames=ThisiDRAFT_0840 {ECO:0000313|EMBL:EGZ48703.1};
OS Thiorhodospira sibirica ATCC 700588.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC Ectothiorhodospiraceae; Thiorhodospira.
OX NCBI_TaxID=765914 {ECO:0000313|EMBL:EGZ48703.1};
RN [1] {ECO:0000313|EMBL:EGZ48703.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700588 {ECO:0000313|EMBL:EGZ48703.1};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Land M.L., Hauser L., Vogl K., Liu Z., Imhoff J.,
RA Frigaard N.-U., Bryant D., Woyke T.;
RT "The draft genome of Thiorhodospira sibirica ATCC 700588.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGZ48703.1}.
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DR EMBL; AGFD01000011; EGZ48703.1; -; Genomic_DNA.
DR RefSeq; WP_006786855.1; NZ_MU255056.1.
DR AlphaFoldDB; G4E3G1; -.
DR STRING; 765914.ThisiDRAFT_0840; -.
DR PATRIC; fig|765914.3.peg.850; -.
DR eggNOG; COG0317; Bacteria.
DR OrthoDB; 9805041at2; -.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF40; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000313|EMBL:EGZ48703.1}.
FT DOMAIN 393..456
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 651..726
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 726 AA; 82413 MW; 3AC116DF575602B1 CRC64;
MRHTQYQKHS LVCEPREALL ARFCNTDNQT QQTDLRISLA LTYALEHKEP SLYHPHCLDV
AEILRVLGVD RETLIATLLI DAHLQETLDS NEIKSNFGER VAGLVNNVHW LITFKGIPRE
TASQPEEAER LRRMLLAMVD DVRAVLIKLA YRLQRLRNLA AHPDSTTLAY ARETLDIFSP
LANRLGIGQL KWEMEDLAFR ILEPEEYRRL ACLLEENRTG RERYIADFMV RLSDALQAEG
LSQAEVRGRP KHIYSIWRKM QKKQLDFEEV YDLRAVRVIV ERISSCYTAL GVVHSLWPHI
PREFDDYIAN PKDNGYQSLH TAVIGPQAKV VEVQIRTRDM DEFAELGVAA HWRYKEGGTE
DKALTRAIAS LRRLLDNKED DNELLDSFRS ELFQDRVFVL TPRGDVIDLP KGATPLDFAY
AIHTEVGHRC RGAKINGRIV TLTYELKSGE RVEVLTTRQG GPSRDWLNPH MGYLRTSRAR
AKARSWFKQQ DQDRNLIEGK AIFERECQRL AVEHPDIDEL LRRYRYARKE DLLIAIGAGE
ITPAQLAHAL QVPIPLTPAQ ALLAHSNKRR PSSGKAASSG IHIRGVGNLL TQIARCCRPV
PGDSIIGFIT RGKGVSIHRR DCVNILRMPG EKRSRLVEVS WGDEPHAYPV NVYIEAFDRQ
GLLRDITSIL ANDKVNVLSA STRTDRVDQS VSMDLTLEIS DTGQLSAVMD KIGALSNVTA
IRRKPG
//
