ID G4QET0_GLANF Unreviewed; 1052 AA.
AC G4QET0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Error-prone DNA polymerase {ECO:0000256|ARBA:ARBA00017273, ECO:0000256|HAMAP-Rule:MF_01902};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|HAMAP-Rule:MF_01902};
GN Name=dnaE {ECO:0000313|EMBL:AEP28193.1};
GN Synonyms=dnaE2 {ECO:0000256|HAMAP-Rule:MF_01902};
GN OrderedLocusNames=GNIT_0038 {ECO:0000313|EMBL:AEP28193.1};
OS Glaciecola nitratireducens (strain JCM 12485 / KCTC 12276 / FR1064).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Glaciecola.
OX NCBI_TaxID=1085623 {ECO:0000313|EMBL:AEP28193.1, ECO:0000313|Proteomes:UP000009282};
RN [1] {ECO:0000313|EMBL:AEP28193.1, ECO:0000313|Proteomes:UP000009282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 12485 / KCTC 12276 / FR1064
RC {ECO:0000313|Proteomes:UP000009282};
RX PubMed=22123761; DOI=10.1128/JB.06296-11;
RA Bian F., Qin Q.L., Xie B.B., Shu Y.L., Zhang X.Y., Yu Y., Chen B.,
RA Chen X.L., Zhou B.C., Zhang Y.Z.;
RT "Complete genome sequence of seawater bacterium Glaciecola nitratireducens
RT FR1064T.";
RL J. Bacteriol. 193:7006-7007(2011).
CC -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC translesion synthesis (TLS). It is not the major replicative DNA
CC polymerase. {ECO:0000256|HAMAP-Rule:MF_01902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632, ECO:0000256|HAMAP-
CC Rule:MF_01902};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01902}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC subfamily. {ECO:0000256|ARBA:ARBA00007391, ECO:0000256|HAMAP-
CC Rule:MF_01902}.
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DR EMBL; CP003060; AEP28193.1; -; Genomic_DNA.
DR AlphaFoldDB; G4QET0; -.
DR STRING; 1085623.GNIT_0038; -.
DR KEGG; gni:GNIT_0038; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_4_0_6; -.
DR Proteomes; UP000009282; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07434; PHP_PolIIIA_DnaE2; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR HAMAP; MF_01902; DNApol_error_prone; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR023073; DnaE2.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01902};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|HAMAP-Rule:MF_01902};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_01902}; Reference proteome {ECO:0000313|Proteomes:UP000009282};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_01902}.
FT DOMAIN 20..89
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1052 AA; 119560 MW; D1A9C74EBA0A830C CRC64;
MKTGLYMATL SKSNRHVGFA ELVCQTNFSF LHGASHPQEM VRQAYFLQYK AIAITDECSM
AGIVRAYAEI SQHHLPIKMI VGSKFIFNDN TIVLLCPNKA AYSECCRIIT NARRRANKGE
YELSEWDLKS IKHCLCIWLP SGDETRDHDW ARWLTKHYVG RVWLGIKRWL TANEYQYISH
CETLAEQFHF EIIATSCALM HDPNRQALQH CQHAIREGKL IKELGRDALS NQEACLRPLN
KLANLYPQEW LENSVSVAKL CTFDLSELSY QYPAEILPAK YTPSEYLRVL VEQGIQKRFL
NGVSESIRAT IEKELKLIHE QAYEYFFLTI YDVVQFAKAK NILYQGRGSA ANSIVCYCLE
ITAVDPRQIS VLFERFISKE RNEPPDIDVD FEHERREEII QYIYSKYGRE RTAIAATVVC
YRFKSALREV GKVIGVNATD LDYFIKNVNR RDRDLSWQSQ LTELGIDPDS QNGKHFIHLV
EQLIGFPRHL SQHVGGFVIS AGPLYEMVPI ENASMQDRTV IQWDKDDLET LKLLKVDVLA
LGMLTAIRKS FDLIKQHYQH DYTIPFITAL PDDPQVFKQI QKADTVGVFQ IESRAQMSML
PRLKPKKYYD LVVQIAIVRP GPIQGDMVHP YLLRRDGKEQ VEYPSPEVQS VLERTMGVPI
FQEQVIQLAM VAAGFTGGEA DGLRRAMASW KKNGDLYKFK QKLTDGMTQR GYSHDYAMRL
FEQICGFGEY GFPESHSASF AVLAYVSAWL KHYYPEAFYV GLLNSLPMGF YSPSQIIQDA
KQHQVKILGF CVNKSGYDHS LQRLIANAAV NDEPVSTSKL SIRMGLRLIK GLKSDSVNTV
IKYRPVGGYK SIDQIRQLGL PSSCLQALAS ANAFSSMADN RYQARWELMD SVMELPLFSQ
HTSANDNYAK QPSLFDNLVE DYASTGLSID LHPIALLSQA NLLPKFYLAN TLRDVPHQTL
VSVIGVVTGK QSPGTAAGVT FITLEDHTGN INVVVWQSSA REQKKVYMNA KILQIKGILE
RGDGDVVHII AGRLIDQTHL LSKLDTKSRE FR
//
