ID G4QGI5_GLANF Unreviewed; 1132 AA.
AC G4QGI5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Mechanosensitive ion channel protein MscS {ECO:0000313|EMBL:AEP29622.1};
GN Name=kefA {ECO:0000313|EMBL:AEP29622.1};
GN OrderedLocusNames=GNIT_1504 {ECO:0000313|EMBL:AEP29622.1};
OS Glaciecola nitratireducens (strain JCM 12485 / KCTC 12276 / FR1064).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Glaciecola.
OX NCBI_TaxID=1085623 {ECO:0000313|EMBL:AEP29622.1, ECO:0000313|Proteomes:UP000009282};
RN [1] {ECO:0000313|EMBL:AEP29622.1, ECO:0000313|Proteomes:UP000009282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 12485 / KCTC 12276 / FR1064
RC {ECO:0000313|Proteomes:UP000009282};
RX PubMed=22123761; DOI=10.1128/JB.06296-11;
RA Bian F., Qin Q.L., Xie B.B., Shu Y.L., Zhang X.Y., Yu Y., Chen B.,
RA Chen X.L., Zhou B.C., Zhang Y.Z.;
RT "Complete genome sequence of seawater bacterium Glaciecola nitratireducens
RT FR1064T.";
RL J. Bacteriol. 193:7006-7007(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; CP003060; AEP29622.1; -; Genomic_DNA.
DR RefSeq; WP_014108496.1; NC_016041.1.
DR AlphaFoldDB; G4QGI5; -.
DR STRING; 1085623.GNIT_1504; -.
DR KEGG; gni:GNIT_1504; -.
DR eggNOG; COG3264; Bacteria.
DR HOGENOM; CLU_007829_1_1_6; -.
DR OrthoDB; 9799209at2; -.
DR Proteomes; UP000009282; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF1; MINICONDUCTANCE MECHANOSENSITIVE CHANNEL MSCM; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009282};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1132
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003467266"
FT TRANSMEM 506..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 706..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..766
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 820..837
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 868..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 908..929
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 941..969
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..275
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 518..853
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 915..955
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 957..1022
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 1030..1113
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT COILED 44..148
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1132 AA; 125673 MW; FA3933D61EB4EEF3 CRC64;
MSESFFNRSN KLRCIISLGL FFLLTSPKAM AQYVDLNIEI KGATESAKQN ADLTEEQRKQ
VLAELNDASI LLTKAQEQIN LANTYEKLAA SASQKVITIE RNIQQLRDKS VNIDTRRPFI
ELENQLLLEE SQQTREFANL TQKQAEQTNL SLRANEIAQQ LSSLRIDKTE ITDDLNQQAV
NGLSLLAISK DLKKRANVAK LSETIKTLER EVATIPARQS LVNAELIELR VKNEFQEKRI
SALRSFLAAS RTSKVEKIVQ QNKQTLGALL QHPKLTSIAQ ENLALAEQLE RLQANSYKSE
ESTDKLQGQL LEVQQSSETV ERVLATGRVT DELGELLRRL RASIPREAAI ELRKSDIEED
AVRHQLNVIL WQERLRGLAN IAAAAQNLLF EQSTEKASKT TMQQKDANDY FSPFQLEEAQ
ALTIARRNLL QELIELSNYQ SDRIIEEKLI INQLLSASIG LRELLERRLI WLPSNSGKAG
NLGVNLRDSM DWLFSPKAWW DLLQDFYKGA LAVSVLPLTL FAFAMLIVLG RSKIKRTLWS
LVDGVGKVQK DTYQTTPLAL LLTLVLALPL PLCLFAVATT IYKGAAPLSF ANAIATGLSS
VSSISLVLLF FRSMSRKDGL FEKHFGWSDV SRIKLRSMLT WFVWLQSLAA FLFASAIASG
LTELRYGLAI LAFIIGSIGI AVFSYQFFQP KNGVATSIVG ETPVSVLTIL AFPIVVAAPL
FIGLLPLFGF FDTAVELQSR LFSSGILLVF ASVAYGIMLR IFLVAFRRYI VKKERLDAAE
AEALALQNQE LSESGVESTA SEPPAEGIDE QEVMRQGRSI MLWITALFFI AGLWFIWKSL
LPALGIVDDI VLWQEIKMVD GVELSSGVTL WDIILSLGFV IGGFVAAKNI RGVMEIGFFE
RFEMDAGARY ATITILGYVL VGAGIVIGFS QLGIDWSKLQ WIIAALGVGL GFGLQEIVAN
FVSGLIILFE RPIRVGDFVT IGNLSGTVSN IKIRATTVTD FDNREVLLPN KSIITENVTN
WTLKDSVTRI VVKIGVAYGS DIDKVKGLLM QVAEGLDEVL KQPAPQVFFL EHGDSSLNFE
IRVFVVRPED RLPLTHAINT GVNKALAENN ISIPFPQRDL HIVSGHLGNT TV
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