ID G4QLL6_GLANF Unreviewed; 510 AA.
AC G4QLL6;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:AEP30122.1};
GN OrderedLocusNames=GNIT_2013 {ECO:0000313|EMBL:AEP30122.1};
OS Glaciecola nitratireducens (strain JCM 12485 / KCTC 12276 / FR1064).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Glaciecola.
OX NCBI_TaxID=1085623 {ECO:0000313|EMBL:AEP30122.1, ECO:0000313|Proteomes:UP000009282};
RN [1] {ECO:0000313|EMBL:AEP30122.1, ECO:0000313|Proteomes:UP000009282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 12485 / KCTC 12276 / FR1064
RC {ECO:0000313|Proteomes:UP000009282};
RX PubMed=22123761; DOI=10.1128/JB.06296-11;
RA Bian F., Qin Q.L., Xie B.B., Shu Y.L., Zhang X.Y., Yu Y., Chen B.,
RA Chen X.L., Zhou B.C., Zhang Y.Z.;
RT "Complete genome sequence of seawater bacterium Glaciecola nitratireducens
RT FR1064T.";
RL J. Bacteriol. 193:7006-7007(2011).
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DR EMBL; CP003060; AEP30122.1; -; Genomic_DNA.
DR RefSeq; WP_014108996.1; NC_016041.1.
DR AlphaFoldDB; G4QLL6; -.
DR STRING; 1085623.GNIT_2013; -.
DR KEGG; gni:GNIT_2013; -.
DR eggNOG; COG0654; Bacteria.
DR HOGENOM; CLU_022247_1_0_6; -.
DR OrthoDB; 7178350at2; -.
DR Proteomes; UP000009282; Chromosome.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000009282}.
FT ACT_SITE 83
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 9..12
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 83
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 344
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 353
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 510 AA; 57572 MW; C58FBFC9C47A0FD7 CRC64;
MKKLLILGGG TAGWMAANML NHYFTESKVI NPNQKSWQIT LVESPQIGII GVGEGSTPQL
KKFFDLLGIQ ESEWMPACHA TYKNGISFLQ WSEHQATNRY FHPFPSPFDR QTASAFLYHC
QMRSRGMDVP VNPDDFFLSA KLAQLNRSPK PLLGKPQIPL NYAYHFDSAK LGAFLCQRAV
NRGVVHINGK MERAIQDKDK SMRAIKLATG ETLDADLFID ATGFNSLLLQ GVLEEPFDSF
DSNLFNNKAV AIPSTSQKII PSETKATALS AGWAWQIPLT NRTGNGYVYS DQYLSPEQAE
EELRRHINSN IADESETRSE AKHLNMKVGQ VQRHWHKNVV AVGLSQGFIE PLEATALHLV
QETIQKLAAS LTDPSFDSEQ ERIKLRFNEA IKRRFNGIRD YIVCHYKMNT RTDSQYWVDN
RENNNISTQL ADVIDTWRSK KDIAAVLEQH QMTHYYPVIS WYCLLAGYGS FAPATSPNKL
PSSNMKQLAH YIMQNASHFA PHNESLGIST
//
