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Database: UniProt
Entry: G4RLL6_THETK
LinkDB: G4RLL6_THETK
Original site: G4RLL6_THETK 
ID   G4RLL6_THETK            Unreviewed;       419 AA.
AC   G4RLL6;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=anthranilate synthase {ECO:0000256|ARBA:ARBA00012266};
DE            EC=4.1.3.27 {ECO:0000256|ARBA:ARBA00012266};
GN   Name=trpE {ECO:0000313|EMBL:CCC82461.1};
GN   OrderedLocusNames=TTX_1843 {ECO:0000313|EMBL:CCC82461.1};
OS   Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435
OS   / Kra 1).
OC   Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Thermoproteus.
OX   NCBI_TaxID=768679 {ECO:0000313|EMBL:CCC82461.1, ECO:0000313|Proteomes:UP000002654};
RN   [1] {ECO:0000313|EMBL:CCC82461.1, ECO:0000313|Proteomes:UP000002654}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1
RC   {ECO:0000313|Proteomes:UP000002654};
RX   PubMed=22003381; DOI=10.1371/journal.pone.0024222;
RA   Siebers B., Zaparty M., Raddatz G., Tjaden B., Albers S.V., Bell S.D.,
RA   Blombach F., Kletzin A., Kyrpides N., Lanz C., Plagens A., Rampp M.,
RA   Rosinus A., von Jan M., Makarova K.S., Klenk H.P., Schuster S.C.,
RA   Hensel R.;
RT   "The complete genome sequence of Thermoproteus tenax: a physiologically
RT   versatile member of the Crenarchaeota.";
RL   PLoS ONE 6:E24222-E24222(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chorismate + L-glutamine = anthranilate + H(+) + L-glutamate +
CC         pyruvate; Xref=Rhea:RHEA:21732, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16567, ChEBI:CHEBI:29748, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:58359; EC=4.1.3.27;
CC         Evidence={ECO:0000256|ARBA:ARBA00000329};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5. {ECO:0000256|ARBA:ARBA00004873}.
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DR   EMBL; FN869859; CCC82461.1; -; Genomic_DNA.
DR   RefSeq; WP_014127715.1; NC_016070.1.
DR   AlphaFoldDB; G4RLL6; -.
DR   STRING; 768679.TTX_1843; -.
DR   PaxDb; 768679-TTX_1843; -.
DR   GeneID; 11262728; -.
DR   KEGG; ttn:TTX_1843; -.
DR   PATRIC; fig|768679.9.peg.1866; -.
DR   eggNOG; arCOG02014; Archaea.
DR   HOGENOM; CLU_006493_7_1_2; -.
DR   OMA; YSRVQHI; -.
DR   OrthoDB; 25514at2157; -.
DR   UniPathway; UPA00035; UER00040.
DR   Proteomes; UP000002654; Chromosome.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I-like.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR015890; Chorismate_C.
DR   PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR   PANTHER; PTHR11236:SF9; ANTHRANILATE SYNTHASE COMPONENT 1; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   SUPFAM; SSF56322; ADC synthase; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022822};
KW   Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00022822};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:CCC82461.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002654};
KW   Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT   DOMAIN          41..130
FT                   /note="Anthranilate synthase component I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04715"
FT   DOMAIN          158..410
FT                   /note="Chorismate-utilising enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00425"
SQ   SEQUENCE   419 AA;  46624 MW;  3F5EAD7C7365D72D CRC64;
     MVKVPLSELP SPRSLAKSLY ISGEEFVALL ESGPGFPDRA RYTIVAWGIR EEVRASSRVY
     DELQRLYRGL QRYEGPFGGD LAIGFVAYDV VVEIEPSLTG KIKTDNAFPL GVFVVPENVV
     IYDNLLKRAY VVGRTPAISM QSEGRPLRQG RTLYRTDDEY FKRSVAEALR RIKDGEIFQV
     VLSRSEVFEI SGNLFNAYER LATLNPSPYM YFFALDDMAL IGTSPELLVK VQGDIVETHP
     IAGTRPRGST EREDLKLEED MLSDEKELAE HMMLVDLARN DVGKISRFGT VKVNELLAIE
     KYSHVQHLVS RVSGVLEPKY NIVDGIWALH PAGTVSGAPK VRAMEIIGEL EDRPRGPYAG
     GFGVMAPSGG ELAIVIRTLI VKGNEAKIQA GAGVVYDSTP ERELRETEYK MAHLKAIWT
//
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