ID G4RLL6_THETK Unreviewed; 419 AA.
AC G4RLL6;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=anthranilate synthase {ECO:0000256|ARBA:ARBA00012266};
DE EC=4.1.3.27 {ECO:0000256|ARBA:ARBA00012266};
GN Name=trpE {ECO:0000313|EMBL:CCC82461.1};
GN OrderedLocusNames=TTX_1843 {ECO:0000313|EMBL:CCC82461.1};
OS Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435
OS / Kra 1).
OC Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Thermoproteus.
OX NCBI_TaxID=768679 {ECO:0000313|EMBL:CCC82461.1, ECO:0000313|Proteomes:UP000002654};
RN [1] {ECO:0000313|EMBL:CCC82461.1, ECO:0000313|Proteomes:UP000002654}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1
RC {ECO:0000313|Proteomes:UP000002654};
RX PubMed=22003381; DOI=10.1371/journal.pone.0024222;
RA Siebers B., Zaparty M., Raddatz G., Tjaden B., Albers S.V., Bell S.D.,
RA Blombach F., Kletzin A., Kyrpides N., Lanz C., Plagens A., Rampp M.,
RA Rosinus A., von Jan M., Makarova K.S., Klenk H.P., Schuster S.C.,
RA Hensel R.;
RT "The complete genome sequence of Thermoproteus tenax: a physiologically
RT versatile member of the Crenarchaeota.";
RL PLoS ONE 6:E24222-E24222(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate + L-glutamine = anthranilate + H(+) + L-glutamate +
CC pyruvate; Xref=Rhea:RHEA:21732, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16567, ChEBI:CHEBI:29748, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:58359; EC=4.1.3.27;
CC Evidence={ECO:0000256|ARBA:ARBA00000329};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 1/5. {ECO:0000256|ARBA:ARBA00004873}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN869859; CCC82461.1; -; Genomic_DNA.
DR RefSeq; WP_014127715.1; NC_016070.1.
DR AlphaFoldDB; G4RLL6; -.
DR STRING; 768679.TTX_1843; -.
DR PaxDb; 768679-TTX_1843; -.
DR GeneID; 11262728; -.
DR KEGG; ttn:TTX_1843; -.
DR PATRIC; fig|768679.9.peg.1866; -.
DR eggNOG; arCOG02014; Archaea.
DR HOGENOM; CLU_006493_7_1_2; -.
DR OMA; YSRVQHI; -.
DR OrthoDB; 25514at2157; -.
DR UniPathway; UPA00035; UER00040.
DR Proteomes; UP000002654; Chromosome.
DR GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR015890; Chorismate_C.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF9; ANTHRANILATE SYNTHASE COMPONENT 1; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022822};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00022822};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:CCC82461.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002654};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 41..130
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 158..410
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 419 AA; 46624 MW; 3F5EAD7C7365D72D CRC64;
MVKVPLSELP SPRSLAKSLY ISGEEFVALL ESGPGFPDRA RYTIVAWGIR EEVRASSRVY
DELQRLYRGL QRYEGPFGGD LAIGFVAYDV VVEIEPSLTG KIKTDNAFPL GVFVVPENVV
IYDNLLKRAY VVGRTPAISM QSEGRPLRQG RTLYRTDDEY FKRSVAEALR RIKDGEIFQV
VLSRSEVFEI SGNLFNAYER LATLNPSPYM YFFALDDMAL IGTSPELLVK VQGDIVETHP
IAGTRPRGST EREDLKLEED MLSDEKELAE HMMLVDLARN DVGKISRFGT VKVNELLAIE
KYSHVQHLVS RVSGVLEPKY NIVDGIWALH PAGTVSGAPK VRAMEIIGEL EDRPRGPYAG
GFGVMAPSGG ELAIVIRTLI VKGNEAKIQA GAGVVYDSTP ERELRETEYK MAHLKAIWT
//