ID G4RP35_THETK Unreviewed; 151 AA.
AC G4RP35;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Riboflavin synthase {ECO:0000256|ARBA:ARBA00013950};
DE EC=2.5.1.9 {ECO:0000256|ARBA:ARBA00012827};
GN OrderedLocusNames=TTX_0669 {ECO:0000313|EMBL:CCC81330.1};
OS Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435
OS / Kra 1).
OC Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Thermoproteus.
OX NCBI_TaxID=768679 {ECO:0000313|EMBL:CCC81330.1, ECO:0000313|Proteomes:UP000002654};
RN [1] {ECO:0000313|EMBL:CCC81330.1, ECO:0000313|Proteomes:UP000002654}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1
RC {ECO:0000313|Proteomes:UP000002654};
RX PubMed=22003381; DOI=10.1371/journal.pone.0024222;
RA Siebers B., Zaparty M., Raddatz G., Tjaden B., Albers S.V., Bell S.D.,
RA Blombach F., Kletzin A., Kyrpides N., Lanz C., Plagens A., Rampp M.,
RA Rosinus A., von Jan M., Makarova K.S., Klenk H.P., Schuster S.C.,
RA Hensel R.;
RT "The complete genome sequence of Thermoproteus tenax: a physiologically
RT versatile member of the Crenarchaeota.";
RL PLoS ONE 6:E24222-E24222(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-
CC ribitylamino)uracil + riboflavin; Xref=Rhea:RHEA:20772,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15934, ChEBI:CHEBI:57986,
CC ChEBI:CHEBI:58201; EC=2.5.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000968};
CC -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; riboflavin
CC from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-
CC ribitylamino)uracil: step 2/2. {ECO:0000256|ARBA:ARBA00004887}.
CC -!- SIMILARITY: Belongs to the DMRL synthase family.
CC {ECO:0000256|ARBA:ARBA00007424}.
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DR EMBL; FN869859; CCC81330.1; -; Genomic_DNA.
DR RefSeq; WP_014126586.1; NC_016070.1.
DR AlphaFoldDB; G4RP35; -.
DR STRING; 768679.TTX_0669; -.
DR PaxDb; 768679-TTX_0669; -.
DR GeneID; 11261566; -.
DR KEGG; ttn:TTX_0669; -.
DR PATRIC; fig|768679.9.peg.684; -.
DR eggNOG; arCOG01322; Archaea.
DR HOGENOM; CLU_1682776_0_0_2; -.
DR OrthoDB; 23911at2157; -.
DR UniPathway; UPA00275; UER00405.
DR Proteomes; UP000002654; Chromosome.
DR GO; GO:0009349; C:riboflavin synthase complex; IEA:InterPro.
DR GO; GO:0004746; F:riboflavin synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.960; Lumazine/riboflavin synthase; 1.
DR InterPro; IPR002180; LS/RS.
DR InterPro; IPR036467; LS/RS_sf.
DR InterPro; IPR006399; Ribfl_synth_arc.
DR NCBIfam; TIGR01506; ribC_arch; 1.
DR Pfam; PF00885; DMRL_synthase; 1.
DR SUPFAM; SSF52121; Lumazine synthase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002654};
KW Riboflavin biosynthesis {ECO:0000256|ARBA:ARBA00022619};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CCC81330.1}.
SQ SEQUENCE 151 AA; 16361 MW; 03C0079DBFED94C2 CRC64;
MDCIGVVDTT FARVDMGSEA IDELRSLAPD VVVKRITVPG IKNTIWGAKK LMKEGCTAIL
VVGWVGPSLT DKLSYLAMSL GLIELQIQYD VLILDATVHE DEATDEGELK LIAIDRARKH
ARNLVALLRG DLTEAAGRGL RQGRPDVGPI I
//
