ID G4STY5_META2 Unreviewed; 815 AA.
AC G4STY5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN OrderedLocusNames=MEALZ_1117 {ECO:0000313|EMBL:CCE22808.1};
OS Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM
OS B-2133 / 20Z) (Methylomicrobium alcaliphilum).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylotuvimicrobium.
OX NCBI_TaxID=1091494 {ECO:0000313|EMBL:CCE22808.1, ECO:0000313|Proteomes:UP000008315};
RN [1] {ECO:0000313|Proteomes:UP000008315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z
RC {ECO:0000313|Proteomes:UP000008315};
RX PubMed=22207753; DOI=10.1128/JB.06392-11;
RA Vuilleumier S., Khmelenina V.N., Bringel F., Reshetnikov A.S., Lajus A.,
RA Mangenot S., Rouy Z., Op den Camp H.J., Jetten M.S., Dispirito A.A.,
RA Dunfield P., Klotz M.G., Semrau J.D., Stein L.Y., Barbe V., Medigue C.,
RA Trotsenko Y.A., Kalyuzhnaya M.G.;
RT "Genome sequence of the haloalkaliphilic methanotrophic bacterium
RT Methylomicrobium alcaliphilum 20Z.";
RL J. Bacteriol. 194:551-552(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FO082060; CCE22808.1; -; Genomic_DNA.
DR RefSeq; WP_014147607.1; NC_016112.1.
DR AlphaFoldDB; G4STY5; -.
DR STRING; 1091494.MEALZ_1117; -.
DR KEGG; mah:MEALZ_1117; -.
DR PATRIC; fig|271065.3.peg.1141; -.
DR HOGENOM; CLU_005912_8_0_6; -.
DR Proteomes; UP000008315; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008315};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 690..810
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 815 AA; 92447 MW; 127A2D92012322B5 CRC64;
MPLSETLFII LLLLTLALLL SGLCRHLPLP YTILLVVTGV SINLLATVTP FALIPSGFHL
SDELVLFIFH PALIFVSALS LDARTLIKDL LPILVMAIPG MLISALLVAV GLNTFFYLNF
ILAFLFGAII SATDPVAVIA LFKELGVSKR LTVLVEGESL FNDATAIVLF NIVLGAVIHG
ESALMDAPTM IYYFTEHFLL GALIGTVIGL LISEMMVRMY HGQQSFVVVA SIVAAYLSFI
VAEHNFHASG IMSVLATALC IKGIAMSRLS GESTHHIEAG WDIISLVLNS LLFLLIGLTV
DIFAFAIHWQ QLTWVLLAIF AARMISVYGL IPMTTSLFSL PAISLNSRHM MWWGCSKGTI
AIAMALAIPD TVVDRGLLLE LTLGMVLISL VMSGPTLKPL MRALKIDRLN DDEWLELQEG
MEQISTSVND CLHSFSRLHL LESDMQDSVL QSLNRKIAPR HATLTEAQQL RQIHLHALNV
EERELQRLHE IGLVNYYTYL NFKDILRKDK AKSIDEMIRF NKNQDNVNPF LRFEMSIIKF
LSEYEWTLNW LIRYQKIRFA NLIRHDLAGV LMAHEALLAL KQVEPHFHSD KLNIIRKIYR
QRLERRQGRL KKLGKQFHDF YYQFEYRLFQ EVALRYSLKL ITEDFEHGKV SEKIYRRLEK
RLDEALKQLP DLAPELSLSK RDDWLDSVPI FNGLPRDVLK KLAKNAHYVS FLPNDTIFNE
NDRGDSIYIL VNGVVNVFQN TGPNQRVHIA ELRKGSFIGR HALYDHAVRT ATVRAKTYVT
LLRLTTQDIK TLSKALPELN QRLQETDINR YPNNT
//
