ID G4SVW5_META2 Unreviewed; 402 AA.
AC G4SVW5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase {ECO:0000313|EMBL:CCE25200.1};
DE EC=1.1.1.- {ECO:0000313|EMBL:CCE25200.1};
GN Name=rffD {ECO:0000313|EMBL:CCE25200.1};
GN OrderedLocusNames=MEALZ_3538 {ECO:0000313|EMBL:CCE25200.1};
OS Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM
OS B-2133 / 20Z) (Methylomicrobium alcaliphilum).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylotuvimicrobium.
OX NCBI_TaxID=1091494 {ECO:0000313|EMBL:CCE25200.1, ECO:0000313|Proteomes:UP000008315};
RN [1] {ECO:0000313|Proteomes:UP000008315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z
RC {ECO:0000313|Proteomes:UP000008315};
RX PubMed=22207753; DOI=10.1128/JB.06392-11;
RA Vuilleumier S., Khmelenina V.N., Bringel F., Reshetnikov A.S., Lajus A.,
RA Mangenot S., Rouy Z., Op den Camp H.J., Jetten M.S., Dispirito A.A.,
RA Dunfield P., Klotz M.G., Semrau J.D., Stein L.Y., Barbe V., Medigue C.,
RA Trotsenko Y.A., Kalyuzhnaya M.G.;
RT "Genome sequence of the haloalkaliphilic methanotrophic bacterium
RT Methylomicrobium alcaliphilum 20Z.";
RL J. Bacteriol. 194:551-552(2012).
CC -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR EMBL; FO082060; CCE25200.1; -; Genomic_DNA.
DR RefSeq; WP_014149955.1; NC_016112.1.
DR AlphaFoldDB; G4SVW5; -.
DR STRING; 1091494.MEALZ_3538; -.
DR KEGG; mah:MEALZ_3538; -.
DR PATRIC; fig|271065.3.peg.3655; -.
DR HOGENOM; CLU_023810_3_2_6; -.
DR Proteomes; UP000008315; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR017476; UDP-Glc/GDP-Man.
DR InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR InterPro; IPR028359; UDP_ManNAc/GlcNAc_DH.
DR NCBIfam; TIGR03026; NDP-sugDHase; 1.
DR PANTHER; PTHR43491; UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE; 1.
DR PANTHER; PTHR43491:SF1; UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE; 1.
DR Pfam; PF00984; UDPG_MGDP_dh; 1.
DR Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR PIRSF; PIRSF500136; UDP_ManNAc_DH; 1.
DR PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52413; UDP-glucose/GDP-mannose dehydrogenase C-terminal domain; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CCE25200.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008315}.
FT DOMAIN 311..402
FT /note="UDP-glucose/GDP-mannose dehydrogenase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00984"
SQ SEQUENCE 402 AA; 44175 MW; 58B948B582C8E5DE CRC64;
MQPSVTKVCV IGLGYIGLPT ASLLGTKGFK VFGVDTSEHV VNTINQGKIH IVEPDLDILV
KSAVQSGNLK AGLQPQEADI FILAVPTPFK DEHIPDLSYV EAATRVIAPF VKPGNIVILE
STSPVGTTDD IVAKILSEEG HDVGRDVYVA HCPERVLPGR ILTELVENDR IVGGINEIST
EKVVEFYRAF VRGEILATDA KTAELSKLSE NSFRDVNIAF ANELSLICDQ ENINVWELIK
LANRHPRVNI LQPGPGVGGH CIAVDPWFIV ARSPDQARLI KTAREVNDAK PHWVIDKVKV
SADKFKNPVI GCLGLAFKAD VDDLRESPAL DIVKEIRKQD IGEVLVAEPN LTEHKDFTLL
PYQEVIKRSD IVLLLVDHKP FKSLKAADLK EKILIDTRGV IQ
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