ID   G4SWG1_META2            Unreviewed;       291 AA.
AC   G4SWG1;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Prephenate dehydrogenase (PDH) {ECO:0000313|EMBL:CCE24174.1};
DE            EC=1.3.1.12 {ECO:0000313|EMBL:CCE24174.1};
GN   Name=tyrA {ECO:0000313|EMBL:CCE24174.1};
GN   OrderedLocusNames=MEALZ_2496 {ECO:0000313|EMBL:CCE24174.1};
OS   Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM
OS   B-2133 / 20Z) (Methylomicrobium alcaliphilum).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methylotuvimicrobium.
OX   NCBI_TaxID=1091494 {ECO:0000313|EMBL:CCE24174.1, ECO:0000313|Proteomes:UP000008315};
RN   [1] {ECO:0000313|Proteomes:UP000008315}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z
RC   {ECO:0000313|Proteomes:UP000008315};
RX   PubMed=22207753; DOI=10.1128/JB.06392-11;
RA   Vuilleumier S., Khmelenina V.N., Bringel F., Reshetnikov A.S., Lajus A.,
RA   Mangenot S., Rouy Z., Op den Camp H.J., Jetten M.S., Dispirito A.A.,
RA   Dunfield P., Klotz M.G., Semrau J.D., Stein L.Y., Barbe V., Medigue C.,
RA   Trotsenko Y.A., Kalyuzhnaya M.G.;
RT   "Genome sequence of the haloalkaliphilic methanotrophic bacterium
RT   Methylomicrobium alcaliphilum 20Z.";
RL   J. Bacteriol. 194:551-552(2012).
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DR   EMBL; FO082060; CCE24174.1; -; Genomic_DNA.
DR   RefSeq; WP_014148950.1; NC_016112.1.
DR   AlphaFoldDB; G4SWG1; -.
DR   STRING; 1091494.MEALZ_2496; -.
DR   KEGG; mah:MEALZ_2496; -.
DR   PATRIC; fig|271065.3.peg.2568; -.
DR   HOGENOM; CLU_055968_0_1_6; -.
DR   Proteomes; UP000008315; Chromosome.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CCE24174.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008315}.
FT   DOMAIN          3..291
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
SQ   SEQUENCE   291 AA;  32025 MW;  516D7A587502E588 CRC64;
     MFNKLCLIGV GLIGGSIARA ARDRGLCTTI VAYGREIDLD NLKEARRLGV IDEYFINLEA
     AVQGADCIII ATPVGAIEKV LGELKPYWSE QAVYSDVGST KGNVVDAARR VFGYLPSNFV
     PAHPIAGAEQ SGVTASVNGL FDDKRLIITP VEQTDPKATA TMQQFWQQLG AIVSIMEVDH
     HDAVLAATSH LPHLLAFVLV DLLGRKDEQV EIFKYAAGGF KDFTRIASSD PTMWLDICLA
     NKQKLIPLIQ QLKQELDTME LALENDDSQQ IFQTFTYAGQ ARQRFLDQLI N
//