ID G4T9L1_SERID Unreviewed; 358 AA.
AC G4T9L1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Peroxisome assembly protein 12 {ECO:0000256|ARBA:ARBA00018980, ECO:0000256|PIRNR:PIRNR038074};
DE AltName: Full=Peroxin-12 {ECO:0000256|ARBA:ARBA00029692, ECO:0000256|PIRNR:PIRNR038074};
GN ORFNames=PIIN_01871 {ECO:0000313|EMBL:CCA68004.1};
OS Serendipita indica (strain DSM 11827) (Root endophyte fungus)
OS (Piriformospora indica).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Sebacinales; Serendipitaceae; Serendipita.
OX NCBI_TaxID=1109443 {ECO:0000313|EMBL:CCA68004.1, ECO:0000313|Proteomes:UP000007148};
RN [1] {ECO:0000313|EMBL:CCA68004.1, ECO:0000313|Proteomes:UP000007148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11827 {ECO:0000313|EMBL:CCA68004.1,
RC ECO:0000313|Proteomes:UP000007148};
RX PubMed=22022265; DOI=10.1371/journal.ppat.1002290;
RA Zuccaro A., Lahrmann U., Guldener U., Langen G., Pfiffi S., Biedenkopf D.,
RA Wong P., Samans B., Grimm C., Basiewicz M., Murat C., Martin F.,
RA Kogel K.H.;
RT "Endophytic Life Strategies Decoded by Genome and Transcriptome Analyses of
RT the Mutualistic Root Symbiont Piriformospora indica.";
RL PLoS Pathog. 7:e1002290-e1002290(2011).
CC -!- FUNCTION: Component of a retrotranslocation channel required for
CC peroxisome organization by mediating export of the PEX5 receptor from
CC peroxisomes to the cytosol, thereby promoting PEX5 recycling.
CC {ECO:0000256|PIRNR:PIRNR038074}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBUNIT: Component of the PEX2-PEX10-PEX12 retrotranslocation channel,
CC composed of PEX2, PEX10 and PEX12. {ECO:0000256|ARBA:ARBA00034505}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Peroxisome
CC membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004585}.
CC -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family.
CC {ECO:0000256|ARBA:ARBA00008704, ECO:0000256|PIRNR:PIRNR038074}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCA68004.1}.
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DR EMBL; CAFZ01000023; CCA68004.1; -; Genomic_DNA.
DR AlphaFoldDB; G4T9L1; -.
DR STRING; 1109443.G4T9L1; -.
DR eggNOG; KOG0826; Eukaryota.
DR HOGENOM; CLU_031067_0_0_1; -.
DR InParanoid; G4T9L1; -.
DR OMA; RCPITGY; -.
DR OrthoDB; 65730at2759; -.
DR Proteomes; UP000007148; Unassembled WGS sequence.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016562; P:protein import into peroxisome matrix, receptor recycling; IEA:UniProt.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProt.
DR CDD; cd16451; mRING_PEX12; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017375; PEX12.
DR InterPro; IPR006845; Pex_N.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12888:SF0; PEROXISOME ASSEMBLY PROTEIN 12; 1.
DR PANTHER; PTHR12888; PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12; 1.
DR Pfam; PF04757; Pex2_Pex12; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR PIRSF; PIRSF038074; Peroxisome_assembly_p12; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038074};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140, ECO:0000256|PIRNR:PIRNR038074};
KW Reference proteome {ECO:0000313|Proteomes:UP000007148};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 307..343
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 358 AA; 41499 MW; 89263797D9CF2F6C CRC64;
MDFLSDARQD VYRPSIFELI AQEQLRDLLQ PAVKYVLAHF AQRYPRYLIR IFNKHEELYA
LIMLVVERHY LKLHNASFAE NFYGLTRRRR PKYETEKANL AVGRASEPSK LNDRDIMRSL
LFLVGIPYVR AKAHDYFESI GGGISSDIMD NSTQSSSTQT RQQKLQSIFK RLYPIINAAF
ELWIMTYNVA YLFEKTPYYR PWLAWMGLDL RRAGPVPVME ATVKQYGSLR ERLSSMLRSS
PRFMLDSLKI LLPLSIFFVK FLEWWYSPSS PARALSAAPT GPALPPPRML HPHPKGLYVD
PTNYGQCPIC RNQITNPTVL PTGYVFCYRC IHPRIEESGL CPVTLHPVEL EQLRKIMG
//
