ID   G4TDP8_SERID            Unreviewed;       636 AA.
AC   G4TDP8;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Probable aminopeptidase P, cytoplasmic {ECO:0000313|EMBL:CCA69452.1};
GN   ORFNames=PIIN_03352 {ECO:0000313|EMBL:CCA69452.1};
OS   Serendipita indica (strain DSM 11827) (Root endophyte fungus)
OS   (Piriformospora indica).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Sebacinales; Serendipitaceae; Serendipita.
OX   NCBI_TaxID=1109443 {ECO:0000313|EMBL:CCA69452.1, ECO:0000313|Proteomes:UP000007148};
RN   [1] {ECO:0000313|EMBL:CCA69452.1, ECO:0000313|Proteomes:UP000007148}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11827 {ECO:0000313|EMBL:CCA69452.1,
RC   ECO:0000313|Proteomes:UP000007148};
RX   PubMed=22022265; DOI=10.1371/journal.ppat.1002290;
RA   Zuccaro A., Lahrmann U., Guldener U., Langen G., Pfiffi S., Biedenkopf D.,
RA   Wong P., Samans B., Grimm C., Basiewicz M., Murat C., Martin F.,
RA   Kogel K.H.;
RT   "Endophytic Life Strategies Decoded by Genome and Transcriptome Analyses of
RT   the Mutualistic Root Symbiont Piriformospora indica.";
RL   PLoS Pathog. 7:e1002290-e1002290(2011).
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCA69452.1}.
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DR   EMBL; CAFZ01000055; CCA69452.1; -; Genomic_DNA.
DR   AlphaFoldDB; G4TDP8; -.
DR   STRING; 1109443.G4TDP8; -.
DR   MEROPS; M24.009; -.
DR   eggNOG; KOG2413; Eukaryota.
DR   HOGENOM; CLU_011781_2_3_1; -.
DR   InParanoid; G4TDP8; -.
DR   OMA; EPGMILS; -.
DR   OrthoDB; 869at2759; -.
DR   Proteomes; UP000007148; Unassembled WGS sequence.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763:SF21; X-PRO AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000313|EMBL:CCA69452.1};
KW   Hydrolase {ECO:0000313|EMBL:CCA69452.1};
KW   Protease {ECO:0000313|EMBL:CCA69452.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007148}.
FT   DOMAIN          35..174
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          342..558
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          571..636
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   636 AA;  70836 MW;  B16D8735435247DF CRC64;
     MLRSLRRIST SLLVRRNLAT MGGGELTGST NTTARLTALR ALMKQEANVD AYVVPSEDQH
     GSEYLAACDE RRPFISGFTG SAGTAIVLQD SAMLFTDGRY FLQARQQMDD NWKLMKQGLP
     DVPTWQEYLT KHLPPKSRIG FDPTLISIGD AKALEKDLKD RESELVPTGN LVDEVWGKDR
     PPRPANEVFL LEEKYSGQST KDKIANIRKE LDKKKATATI ISQLDEVAWL FNLRGSDIPF
     NPVFFAYATI TPSSATLYIA KEKLNKDALA ALEADKIEVK PYESIIESLQ VSPLAAKDED
     KILVGGKTSL AVVNAVGKDK VIVDRQPATD LKSLKNEIEV EGFRQSHIRD GAALARYFSW
     LEQQLQSGAK ISESEGADKL EEYRKQLDLF MGLSFPTISS TGPNGAIIHY QPDPKDCATI
     RQDQIYLCDS GAQFKDGTTD VTRTWHFGEP KPEEIRAFTR VLQGHICIDS TIVPEGTSGF
     IIDSFARRAL WQDGLDYRHG TGHGVGHFLC VHEGPQGIGK RITYNDTPLK PGMTLSNEPG
     YYADGKFGIR IESIVVVKKV DTPNRFGDVD YLGFERVTMC PIHRKLIDKS LLTPEELKWV
     NAYHAEVLAK VGPLLSGKNE DDLRAKAWLE RECKPL
//