ID G4TJ84_SERID Unreviewed; 900 AA.
AC G4TJ84;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Peptide hydrolase {ECO:0000256|RuleBase:RU361240};
DE EC=3.4.-.- {ECO:0000256|RuleBase:RU361240};
GN ORFNames=PIIN_05303 {ECO:0000313|EMBL:CCA71364.1};
OS Serendipita indica (strain DSM 11827) (Root endophyte fungus)
OS (Piriformospora indica).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Sebacinales; Serendipitaceae; Serendipita.
OX NCBI_TaxID=1109443 {ECO:0000313|EMBL:CCA71364.1, ECO:0000313|Proteomes:UP000007148};
RN [1] {ECO:0000313|EMBL:CCA71364.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11827 {ECO:0000313|EMBL:CCA71364.1};
RX PubMed=22022265; DOI=10.1371/journal.ppat.1002290;
RA Zuccaro A., Lahrmann U., Guldener U., Langen G., Pfiffi S., Biedenkopf D.,
RA Wong P., Samans B., Grimm C., Basiewicz M., Murat C., Martin F.,
RA Kogel K.H.;
RT "Endophytic Life Strategies Decoded by Genome and Transcriptome Analyses of
RT the Mutualistic Root Symbiont Piriformospora indica.";
RL PLoS Pathog. 7:e1002290-e1002290(2011).
RN [2] {ECO:0000313|EMBL:CCA71364.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 11827 {ECO:0000313|EMBL:CCA71364.1};
RA MIPS;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in vacuolar sorting and osmoregulation.
CC {ECO:0000256|ARBA:ARBA00003273}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004128}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family.
CC {ECO:0000256|ARBA:ARBA00010918, ECO:0000256|RuleBase:RU361240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCA71364.1}.
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DR EMBL; CAFZ01000116; CCA71364.1; -; Genomic_DNA.
DR AlphaFoldDB; G4TJ84; -.
DR STRING; 1109443.G4TJ84; -.
DR eggNOG; KOG2194; Eukaryota.
DR HOGENOM; CLU_006412_1_0_1; -.
DR InParanoid; G4TJ84; -.
DR OMA; FCHTFVN; -.
DR OrthoDB; 277019at2759; -.
DR Proteomes; UP000007148; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03875; M28_Fxna_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR001261; ArgE/DapE_CS.
DR InterPro; IPR048024; Fxna-like_M28_dom.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR PANTHER; PTHR12147:SF56; VACUOLAR MEMBRANE PROTEASE; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00758; ARGE_DAPE_CPG2_1; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|RuleBase:RU361240};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU361240};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU361240};
KW Reference proteome {ECO:0000313|Proteomes:UP000007148};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vacuole {ECO:0000256|ARBA:ARBA00022554};
KW Zinc {ECO:0000256|RuleBase:RU361240}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 120..310
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 900 AA; 100372 MW; 513B02A4C8B06778 CRC64;
MRFHLPPLTP LWVTRGVVVL YVFIFLALVR VHEVLPSAPS QENALRQGIN LEGAWDDLQV
IAQKPHPYNS RENVLVRNYL LDRVKGLARQ YTNIHISDDL VSNTSYVEAQ RLGYYVEGSN
ILVKVLGTNG ALPAVLFSAH FDTSATAPGK FGIPPRFSLM HHIGATDDGV GVVSLLSLIE
QFASQPPLRN TIFNLNNAEE EGLCGAHVFL QHPWAQEADS FLNIEGAGAG GRPILFRASS
SHLVRAFQET SRPHGTVTSS DAFSLGLIRS MTDFEVYAGP GGMKGLDVSF YVNRDKYHTP
QDNIENLQGR APLWAGLKLA RDVGYQIANS VPDKQDEKAV YWDILGRYMA VIDFSTFIAG
IPTLIMIMTG IVVLLAGNLW YKGHTAIYSS EWAYFPWVLM VATLWSLFFT SALSWLNPSV
IYSSPYPVIV CIACSILLSL HFPLHLIGSS VKSSPNSHKT LILSQLVIFA AITLLGYHWV
LSKSAFGGFY FVEFLYAGAT SALILDLGSR TWASYRGSRI TRLASPRTTD EAEEPLLEMS
SRGEAVRRAR PAMYTPHHQG HAWVLEFLVL SVPIAIMTLQ LVLVLAAGLG QTLADGSPPL
MVYAGITVLT FFALLPIAPF AHLLNRLFFI FVAGLFVTTF FYNILAFPFS YNRRIKFFYR
QHLNLDNGRN TVELLGLQPA LRDATFRIPS VRTRTANVTW GKDPDRGLPS ITWQSHSPQL
VPFTPHITPL SMLDELVLSS ATRIDADSAV FTVKGKDTKS CVLQFDQNII DVRVHRRDLV
HADAHGWSGT VIQKEGPYAI PSHGIPMIKL YGREWGAEFE VTVRWNSTDE SQGRHKGWRS
FLFSRGSARW PKRTGRIGCQ WQENVDGRFP ALDELYEHLP DWATLTVKKP FLLADRAFSI
//
