ID G4U8U2_NEUT9 Unreviewed; 1318 AA.
AC G4U8U2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN ORFNames=NEUTE2DRAFT_146538 {ECO:0000313|EMBL:EGZ76821.1};
OS Neurospora tetrasperma (strain FGSC 2509 / P0656).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=510952 {ECO:0000313|EMBL:EGZ76821.1, ECO:0000313|Proteomes:UP000008513};
RN [1] {ECO:0000313|EMBL:EGZ76821.1, ECO:0000313|Proteomes:UP000008513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain FGSC 2509 / P0656 {ECO:0000313|Proteomes:UP000008513};
RX PubMed=21750257; DOI=10.1534/genetics.111.130690;
RA Ellison C.E., Stajich J.E., Jacobson D.J., Natvig D.O., Lapidus A.,
RA Foster B., Aerts A., Riley R., Lindquist E.A., Grigoriev I.V., Taylor J.W.;
RT "Massive changes in genome architecture accompany the transition to self-
RT fertility in the filamentous fungus Neurospora tetrasperma.";
RL Genetics 189:55-69(2011).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
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DR EMBL; GL890999; EGZ76821.1; -; Genomic_DNA.
DR STRING; 510952.G4U8U2; -.
DR eggNOG; KOG0220; Eukaryota.
DR HOGENOM; CLU_002472_7_0_1; -.
DR Proteomes; UP000008513; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008513}.
FT DOMAIN 1073..1089
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 90..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1247..1318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1263
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1264..1281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1304..1318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1318 AA; 147442 MW; 0C6C237E95EEEC19 CRC64;
MGEDFHAHQG RFPRLLSDDY RRRALSGAAI GSEPRHQAFA RGSAFMDDVV IESRPPLHTT
MIPEPLPHPQ LPTCPPTQYN WQDPRGRQVP HGYPVSQSHQ RYLPDTHGNY SLHPVNTYAP
HTPISDPRKP DFSYQPGYGP EHSYNPRSNG NFAGASYPYL AFENITATKS WGPGSGPAHI
TPQRRITESS SIREEPRRDL CSSPYFGNTS ASSSPRTHNG RQHRRLPLSR PASTSTQNST
PVKSRRSNMG ARRDIPRTPS VQNVHPSPLG TTSSSSYHRY RGEEQGNGRG ASIPRAKYSS
RAPLKGLKEC PGTTPGSREM SSPVISQSSS RISTSNSVSQ RDTSETTLRL PRTSLYDRIS
KTQAMSTRST LPTPVLSDSD SDSDAEESSL EKRHGLVGSS SIITPQKESA PTVSTEENDH
VICAISESRS AEVVGIAVIN ITTGQVDLAR ILNDDKYLYQ RLGDTLWKMS SKPEKFLVVN
SVTTNSSKSL LISCLEQDFP AVPIVLWGRE HWSEAEGLRM IERFALRDHV IALKSDLENN
FYTPCAFSAV MKYVQNELNV HFASNALRIR YIQPLNTMGI DRTTVASLEL LQNTRRATAK
NSTLFGILNS TKTPQGHRLL RTTLLQPSTN KEEVIERYES VEELSTNEEL FRELRKALEE
LVRIDFERVI VWISQEQPNP RQPLEEGVPG CTNQGLLLPT HAELTKAEQE LNSILMLKKY
LSGIDALHGI LEAAGCKSRL LRWIRDRFAP EHTEPVQRAM EEMIEDDAAY SKKPIELRNN
RMWAVRAVRN SVLGKARRSF TALTKDLNEY FDMLDNQFNE VLGTRANLYM DSNRRYWLRF
DYSDVEREIQ PQSDVQKGNY GEVSHWKQVS IAGLELINGT RDKKHLKCQT TELLQRSRAI
QLQADIATMQ SDRLVIELKG RLQEHSSLMF DISDAIALLD MLCSFTQAAT TQDYVRPIIT
DSMVIKQARH PIVEARANHY VANDVYSGDQ SGRFQVITGG NMSGKSTFIR SVALIQIMAQ
MGSFVPAQFA SISICDRVFA RVSTDDAPEN NLGTFGVEMR ETNVILRQAT AQSMIIMDEL
GRGTSPKDGQ ALAIAIIEKL IKMKPRVFFA THFTRIPQLL NKIYPRDVLN VHFEGQSQAV
GQITQITLPH TLAGGPVQNE DYGIELARCV LPGSIVDHAE EVLKALREGQ RPPQSGEKGR
EARQRKLTLA LPVVMKQALD STMDDAALGS YLRRLQTEFT LRWFGVEEGE EDGEAEEVDE
NAGEADEGRP AEADKVMDVS QSGRKRPAAE NDGGEEGEDD GAESDAEREG RQKRRKED
//
