ID G4UBB4_NEUT9 Unreviewed; 2211 AA.
AC G4UBB4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEUTE2DRAFT_153224 {ECO:0000313|EMBL:EGZ76235.1};
OS Neurospora tetrasperma (strain FGSC 2509 / P0656).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=510952 {ECO:0000313|EMBL:EGZ76235.1, ECO:0000313|Proteomes:UP000008513};
RN [1] {ECO:0000313|EMBL:EGZ76235.1, ECO:0000313|Proteomes:UP000008513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain FGSC 2509 / P0656 {ECO:0000313|Proteomes:UP000008513};
RX PubMed=21750257; DOI=10.1534/genetics.111.130690;
RA Ellison C.E., Stajich J.E., Jacobson D.J., Natvig D.O., Lapidus A.,
RA Foster B., Aerts A., Riley R., Lindquist E.A., Grigoriev I.V., Taylor J.W.;
RT "Massive changes in genome architecture accompany the transition to self-
RT fertility in the filamentous fungus Neurospora tetrasperma.";
RL Genetics 189:55-69(2011).
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DR EMBL; GL890999; EGZ76235.1; -; Genomic_DNA.
DR STRING; 510952.G4UBB4; -.
DR eggNOG; KOG3519; Eukaryota.
DR HOGENOM; CLU_001112_0_0_1; -.
DR OMA; DQVGWIW; -.
DR Proteomes; UP000008513; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd07589; BAR_DNMBP; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR PANTHER; PTHR22834:SF20; NUCLEAR FUSION PROTEIN FUS2; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008513};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1397..1626
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1660..1870
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1235..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1373..1392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1470..1512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1901..1941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1949..1968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1986..2129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..102
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..863
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..971
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1001
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1373..1388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1481..1502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1901..1925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1986..2056
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2067..2089
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2211 AA; 241129 MW; 02A7F543475B6D29 CRC64;
MDHGSIRIQE EEEEAASTTN FHTLTHELGG GSGSRRHITR SKSQSQYKHH HHHNYHSSLD
NLDRRAPDLY RYLEAKPPHD GHHHHHHHHH DSHTHTHHTR PPSPPPRRRD FHQQDHGSYF
PEHSSPTHPS APAPAPALDF EARPSHLASP SASYTNYSAS RLTSPLASPR LTSPAQSPLA
TSPSASAHSL SQRFPFASHA AAAHHLQAFA ANPRVSESLN LQPDDYYRSF GTSDAAVVTS
RTADPIKKST LAPTSVQQQQ QQQQTLPPST SPGSPSNGAL KPSALPAAAA AASAAAAGTT
KMSGSSRSTH TNPQTPSGAR SGLRSASNPV DDRLGSNARP ALTTANSYGT QGGAHPPSVK
DLKKMFDQTG TSHNNNLPSQ RRQPRPSRDQ TTSTISSSSS IAPASQIKGS SPSVGARVAS
YSTARNGGAA ANGPASRSLP QLSPTTGLPL QSLSRSNGLL FGEILPDEQD SVTAGFGIQG
HHLEGARPRR TSESSSIHDL TMSGPRLRSS SHSDTMGDME PSSPTDWYRG AASALPTTDN
LARVAKNHSR AQSDVVVSYA STKQPLSTSH TRSGRGTATT TTSSSSRATN TGRTTPSTPT
TPLSSTSRLP VMVKRASISE SHGRSSPVST RSNSPVAALK YGPTPTSGRS SRQQHGTPVS
RAKTPATRSH TPTTPATTTT AKRLQTSNRK AAPTNIATPN NNNGRLNAYV SVPAPKLSPS
LRSSRPRQSV ATASTAASRM RCSTDRPPSP DKSNRRAGSK ADNAATIRRR KLSVGPIDFA
QRRETIKLAY SRTIKDQQAK EARETAAADK RKMDLDAVTR AEAKAEAAAL AAAPSSKSSS
DSVDREEAAA ATAGRHTDKK GLEEPLKLIT NLPIIQTPAQ PPASNGRDSP TLGIPGGFVD
SDDELDVPIP QSAISVATAV TEFDEEAQTE PPRPENFAAI DYALGNIVIG HQPPSPRTHE
PPAPTPPLAS PLAAPQSKRL SYHSPFDDDD DVDDDDDVSI EIALDTSVQQ QQQQQQKQQP
SQQQTPTRED FTTTEPTTGP AQQQPDADEY VLQPYTFSSQ NYETTVTILG PENDFRPLYK
DQARDTMPPS GLHHADEPPL NETLGATAAA GPGQSHPQHQ KHQREESRVS EADNLERLED
FYIGPHLRDN IASLRDSTLT LSDNDDPYDA HPSSAAEYQQ TLDSSHSNGL AVPAYLSPGN
RLSQHSAWTD FSFGSDDQNA AALDNQDPRA SRIFKQPTES ELPVSYNNNF ARNRSSLRRP
PPPSPEISPL DKPPRASSSS MLADKVDPRQ SSDLDRDNSA VQRRIPLVSH QTAPVRPSVN
NYDDLDESTY EVLSRPNSYP HVQDDEEFGT AIISSPPSAG LFSFETVDQS QLSRTESKSL
SSEATDNLTQ EQKRLRQRQM VIRELIDTEE IFVRDMSVVE EIYKGTAEAC PQLDSKTIKL
IFRNTDDIIA FHATFLAQLR DGVASVYQPK GRKSPTFAHE ASLKETDTTT LASTNSSGGA
SNKPELDDDK DRQTSLGPLF IKNIDQLKAV HEVYLRTSDL SAKRLIQIQE DDAVKVWLNE
CSEGAKELTA AWSLDSLLIK PMQRLTKYPD IIAHLLKYTP EDHPDRDALV SAKSTVISAI
DEINRTKRNF ELVGQIVGNR KRKESDVRAG LARAFGKRVD KLQGTSNRAP EDEEYAKLHE
RFGDEFLKLQ VVLRDVEFYT RSASTYVHEF LQYVTAMELV MRLQPSRDYA HIESRWVQFS
VSMRDMEKIL DKHLTDVRKQ VIEPFEQVIK CYQNPGLAIK KRAKRRLDYE RYMQLKANGK
KIDKTLAEAV EQYEALDDTL KKELPKLSAL TAEIGRICLA KFVDIQAAWY STWTEKVKAP
LADFDHTPDI PEIYQVFDRD FKEQIERARQ LVILNPVSLR GRTSQSTSDD IGSGSILTKT
RSRPTELLTP RGRGLSINSD YVPTLPTPDL SGRFDLSPTG TGSALPSPGQ YYRDYYSGLF
NGHHSRGNSA APLSPADPSS SSAPRSVPAT HATSTTGGYS TTRPTTGRSF DSGSLPRQST
DSYSAQSASG THHTSHGHGV AHSGHTLSRR GSYTSSHHNY ATSEPRRQSG LFHSALPMDD
ADEVDGHPEL EAGPSNSNHH HEMQTSNGGG GMFISAEAAA EANVMWLAAS LFEFNIETTK
HEGGYPYLTY QAGEIFDVVA EKGELWLAKN QDDPTNVIGW IWSKHFAKLA E
//
