ID G4UD00_NEUT9 Unreviewed; 580 AA.
AC G4UD00;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=MBOAT-domain-containing protein {ECO:0000313|EMBL:EGZ75613.1};
DE Flags: Fragment;
GN ORFNames=NEUTE2DRAFT_148711 {ECO:0000313|EMBL:EGZ75613.1};
OS Neurospora tetrasperma (strain FGSC 2509 / P0656).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=510952 {ECO:0000313|EMBL:EGZ75613.1, ECO:0000313|Proteomes:UP000008513};
RN [1] {ECO:0000313|EMBL:EGZ75613.1, ECO:0000313|Proteomes:UP000008513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain FGSC 2509 / P0656 {ECO:0000313|Proteomes:UP000008513};
RX PubMed=21750257; DOI=10.1534/genetics.111.130690;
RA Ellison C.E., Stajich J.E., Jacobson D.J., Natvig D.O., Lapidus A.,
RA Foster B., Aerts A., Riley R., Lindquist E.A., Grigoriev I.V., Taylor J.W.;
RT "Massive changes in genome architecture accompany the transition to self-
RT fertility in the filamentous fungus Neurospora tetrasperma.";
RL Genetics 189:55-69(2011).
CC -!- FUNCTION: Sterol O-acyltransferase that catalyzes the formation of
CC stery esters. {ECO:0000256|ARBA:ARBA00023568}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
CC Sterol o-acyltransferase subfamily. {ECO:0000256|ARBA:ARBA00009010}.
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DR EMBL; GL891107; EGZ75613.1; -; Genomic_DNA.
DR AlphaFoldDB; G4UD00; -.
DR STRING; 510952.G4UD00; -.
DR eggNOG; KOG0380; Eukaryota.
DR HOGENOM; CLU_018190_2_0_1; -.
DR OMA; FICQMLQ; -.
DR Proteomes; UP000008513; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR InterPro; IPR004299; MBOAT_fam.
DR InterPro; IPR014371; Oat_ACAT_DAG_ARE.
DR PANTHER; PTHR10408:SF26; O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR10408; STEROL O-ACYLTRANSFERASE; 1.
DR Pfam; PF03062; MBOAT; 1.
DR PIRSF; PIRSF000439; Oat_ACAT_DAG_ARE; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008513};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 517
FT /evidence="ECO:0000256|PIRSR:PIRSR000439-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EGZ75613.1"
SQ SEQUENCE 580 AA; 64984 MW; 1587E3E0DB2C035F CRC64;
MTSTSTSADA FAGQGDNILR PRPRKPLHTQ VSQLSHDANG DSDHANGTGA TSVTGVSSGR
STPIPSDAPP SIQSLSTARK QVRAEQRRRI FPTIEFASRV SHFDPNSDYR DFHGFFNLFW
IGLAIMAITT CLRNIKDTGY PLRVQIWGLF TVKLWHLAIA DFLMVATTAV SLPLHKVFRA
APAGGVLTWA KGGMAIQSIY QAIWLAVWIV IPFWLEWTWT AQVFLLLHTM VLLMKMHSYS
FYMGHLSETE KRLRALDDPA TASKAPAYLY PTPENPLGTV ASPKQRAVEA AAEASSKETK
EISTPNEDEE ITQLREDLAR ELTSPMGNIT YPANLTWANY LDYLCCPTLC YEIEYPRTAA
IDWQNLLSKV LAVFGCIFLL TVISEEFILP ALTDASIRLD PTLRAAAGDS GPLTALEGLL
VLAETISWLL FPFMLTFLLV FLVIFEYVLG AFAEITHFAD RHFYSDWWNS TDWMEFSREW
NVPVYNFLRR HVYSASRPHV GKANATVITF LISAVGHEIV MACITKKLRG YGFICQMLQL
PIVMLQKTEL VRGKKTLNNV CFWCSMILGL SLICSLYVLV
//
