ID G4UDE6_NEUT9 Unreviewed; 1247 AA.
AC G4UDE6;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Amino acid permease/ SLC12A domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEUTE2DRAFT_58739 {ECO:0000313|EMBL:EGZ74854.1};
OS Neurospora tetrasperma (strain FGSC 2509 / P0656).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=510952 {ECO:0000313|EMBL:EGZ74854.1, ECO:0000313|Proteomes:UP000008513};
RN [1] {ECO:0000313|EMBL:EGZ74854.1, ECO:0000313|Proteomes:UP000008513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain FGSC 2509 / P0656 {ECO:0000313|Proteomes:UP000008513};
RX PubMed=21750257; DOI=10.1534/genetics.111.130690;
RA Ellison C.E., Stajich J.E., Jacobson D.J., Natvig D.O., Lapidus A.,
RA Foster B., Aerts A., Riley R., Lindquist E.A., Grigoriev I.V., Taylor J.W.;
RT "Massive changes in genome architecture accompany the transition to self-
RT fertility in the filamentous fungus Neurospora tetrasperma.";
RL Genetics 189:55-69(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL891107; EGZ74854.1; -; Genomic_DNA.
DR AlphaFoldDB; G4UDE6; -.
DR eggNOG; KOG1288; Eukaryota.
DR HOGENOM; CLU_001883_4_0_1; -.
DR OMA; NDLPCRA; -.
DR Proteomes; UP000008513; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF72; GH08340P; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008513};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..483
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 495..582
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1179..1243
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 597..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1008
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1087
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1247 AA; 136967 MW; D0D2A3A796A6A9B1 CRC64;
MDHEHQSRRH KLGVVSGVYI PVCLNILSIL MFLRFGSILG QIGLLGMLGL LFIAYSVDFV
TTLSLSAIAS NGEVKGGGAY YLISRSLGPE FGGSIGILFY LAQVLNTALN VVGLIDCLRL
NLGPVMAQGY WWTYLFETGA LLVCTLLCLA GSAMFAKASN ALLAIMVISI LSIPVSAIFL
PSFNDPVSGI EFTGVSLTTL RSNLWPHFAG DEFNGAGTFR DLFGILFPAT SGIFAGASMS
GDLRNPSKDI PRGTLWAMLS TLISYVLVII SLASSTTHGT FLRNTNVIQE TNVWPPIIFA
GEFATCFFSA LMGVIGSAKL MQALARDKLV PGISIFGKGT KKTDEPLLAI FLTYIVAQFA
MFANLNQIAT FISMGYQMTF FVMNLACFLL KIGSAPNFRP GFKFFSWQTA FAGSVLSAAA
MFFIDETYAT TAVSLLVTLF LLIHYLSPPK RWGDVSQNLI YHQVRKYLLR LKPEHIKFWR
PQIILLINNP RKQTRLIQFC NSMKKGGLYI LGHVIVTDDF SAGVTEAKLQ QAAWTKYISE
FSRIKAFVQL TMSPTITWGV RNLILSAGLG GMRPNIAVIG FYNLDDLRRS RPTLRISHQA
PTSHAKSPQT TETKQPVRQR KRGDTSARLM EGFLPTDVIR TEEMMSVIDY LTILEDLALR
YRLNVAVGKG FETLETPRKD GSNTKKYIDL WPIQMSAELS ADGRNVLTTN FDTYTLILQL
GYILDTVPAW KKVYQVRVLV FVEYESEVEE ERGRVKALLE KLRIEAEVLV FWLASGDLGT
YEAIIHGRFR DQKTEKLVND CLVGQEWWEE LQKIRGTHEE TSQPDISSVL NIVESTSGRP
GLYNPHSELP DPRDRRRASW APLADFPKKP TVSQLVRLGV SMGIHTQNLA ANVLDSSEMD
LDGESDSDSS SSSGTLDGDF NDAASVANNG GLEALEPSRV PLLGATRRMS HGDLFDRLKK
PWKDRRSRKA GGPSAQQSYG AVSQDTGHSR NNGSEGRSSK RDDFLSVGTE RSSHTTTPTL
SRQNSSILKS STARKFTSSL VPETRITSDD TGPQIMFAED QARPGISRRS TPGTAALLSS
KQAARNTIDD DNGGGPRTVC FVEPRYDGAS SSPDKSRANS PARTGTGSGS GDVLLDIPEL
LSSYRLQHQQ QQDDDAAEAG SSYSTQGLPL SFNDLPSRAQ HLILNELMRQ NSADTAVLFT
TLPVPEENTC QSEEASLTYL SDVEVLCNGL PPMLLVLSNN MTVTVSL
//
