ID   G4UFG3_NEUT9            Unreviewed;       309 AA.
AC   G4UFG3;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00012980};
DE            EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
GN   ORFNames=NEUTE2DRAFT_147861 {ECO:0000313|EMBL:EGZ74333.1};
OS   Neurospora tetrasperma (strain FGSC 2509 / P0656).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=510952 {ECO:0000313|EMBL:EGZ74333.1, ECO:0000313|Proteomes:UP000008513};
RN   [1] {ECO:0000313|EMBL:EGZ74333.1, ECO:0000313|Proteomes:UP000008513}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=strain FGSC 2509 / P0656 {ECO:0000313|Proteomes:UP000008513};
RX   PubMed=21750257; DOI=10.1534/genetics.111.130690;
RA   Ellison C.E., Stajich J.E., Jacobson D.J., Natvig D.O., Lapidus A.,
RA   Foster B., Aerts A., Riley R., Lindquist E.A., Grigoriev I.V., Taylor J.W.;
RT   "Massive changes in genome architecture accompany the transition to self-
RT   fertility in the filamentous fungus Neurospora tetrasperma.";
RL   Genetics 189:55-69(2011).
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004992}.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|ARBA:ARBA00009776}.
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DR   EMBL; GL891107; EGZ74333.1; -; Genomic_DNA.
DR   AlphaFoldDB; G4UFG3; -.
DR   STRING; 510952.G4UFG3; -.
DR   eggNOG; KOG3327; Eukaryota.
DR   HOGENOM; CLU_049131_3_1_1; -.
DR   OMA; YWHQFDA; -.
DR   Proteomes; UP000008513; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   CDD; cd01672; TMPK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   NCBIfam; TIGR00041; DTMP_kinase; 1.
DR   PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR   PANTHER; PTHR10344:SF1; THYMIDYLATE KINASE; 1.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:EGZ74333.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008513}.
FT   DOMAIN          29..181
FT                   /note="Thymidylate kinase-like"
FT                   /evidence="ECO:0000259|Pfam:PF02223"
SQ   SEQUENCE   309 AA;  33788 MW;  A5579F4513A6C3BB CRC64;
     MASTTTDPTP TTQYGGNNNP IARGALIVVE GLDRSGKTTQ VKLLEDRFLK AGKKVKTMRF
     PDRTTPIGQM IDSYLKSQAQ MDDHVIHLLF SANRWEAVKT ITSELSQGTT LILDRYYHSG
     IVYSAAKQNP SLSLSWARAP EIGLPRPDLV LFLDLDEEQA RLRGGWGHEL YEKAEMQRRV
     RELFWGLSLG RVGTVTVPVG GVSALGGAGT GGERKRGGEE VNKREAVMLA EGPTEMEEVA
     VGAPTPLAGA AGGPHIDREY AFRQEEEDLH VIDASASVEE VAEELWKVVS ARVEAVERGE
     VGKVVRRVL
//