ID   G4UJ46_NEUT9            Unreviewed;      1140 AA.
AC   G4UJ46;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   22-FEB-2023, entry version 46.
DE   SubName: Full=ARM repeat-containing protein {ECO:0000313|EMBL:EGZ74069.1};
GN   ORFNames=NEUTE2DRAFT_149926 {ECO:0000313|EMBL:EGZ74069.1};
OS   Neurospora tetrasperma (strain FGSC 2509 / P0656).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=510952 {ECO:0000313|EMBL:EGZ74069.1, ECO:0000313|Proteomes:UP000008513};
RN   [1] {ECO:0000313|EMBL:EGZ74069.1, ECO:0000313|Proteomes:UP000008513}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=strain FGSC 2509 / P0656 {ECO:0000313|Proteomes:UP000008513};
RX   PubMed=21750257; DOI=10.1534/genetics.111.130690;
RA   Ellison C.E., Stajich J.E., Jacobson D.J., Natvig D.O., Lapidus A.,
RA   Foster B., Aerts A., Riley R., Lindquist E.A., Grigoriev I.V., Taylor J.W.;
RT   "Massive changes in genome architecture accompany the transition to self-
RT   fertility in the filamentous fungus Neurospora tetrasperma.";
RL   Genetics 189:55-69(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; GL891217; EGZ74069.1; -; Genomic_DNA.
DR   AlphaFoldDB; G4UJ46; -.
DR   STRING; 510952.G4UJ46; -.
DR   eggNOG; KOG2051; Eukaryota.
DR   HOGENOM; CLU_002633_1_1_1; -.
DR   OMA; DFQHHQI; -.
DR   Proteomes; UP000008513; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   Gene3D; 1.25.40.180; -; 3.
DR   Gene3D; 4.10.80.160; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   InterPro; IPR039762; Nmd2/UPF2.
DR   InterPro; IPR007193; Upf2/Nmd2_C.
DR   PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR   PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR   Pfam; PF02854; MIF4G; 2.
DR   Pfam; PF04050; Upf2; 1.
DR   SMART; SM00543; MIF4G; 2.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008513}.
FT   DOMAIN          470..659
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   DOMAIN          674..881
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   REGION          171..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          242..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          905..1068
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1103..1140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..273
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        916..948
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        950..975
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        983..1009
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1050..1064
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1140 AA;  129430 MW;  38B22B0FA743B1BD CRC64;
     MDRQRRRELR ALNSRAWNGE KDLFPVSKSL DSTLKKNTAF IKRLRTTISA ATQSTFLQEI
     RTVSLSKYLS EIISACYEGL CKLKSPGDIE AGVEIVSALH QRFGPADFTE HLGWLLGKGM
     ATPDKSFLKT LTPEAREKEE KDRLVRQRVL LRIVTELWLV DVLRTLDDIA RPDDATRPTT
     GARAEPKPRS SSGKGGGAEP FPLEVLKDLL NHDRDHANLP LLVIFVKAFS WDILGIKAAG
     QDGRKTVEED GATKGAEETE GDGSEDKEEG AGTDQDGPFA PPELQERFKN ILKRYFEDVK
     GHLVRDQKAI YNQSRKNAEA YVKSGEVFED RQSNFEKQVK AQERLVANAQ VIADIIGAEM
     PELKDTDEGN SANGTIGLVK AGEYLRGQGE GPGIWEDEEE RRFYENLVDL KGKVPGILLE
     EVKKKKADDE QVGRKIDPVE AAEAAKAAEA AAADDQSIAI ANKTIGAQVD ALLVRLPELI
     SKDAIDQMAI DFCFLNSKAS RNRLIKALTD VPKGRTDLLP NWARLVATLG QYMPDIPKGL
     VDYLDNEFRS LQRRKEKEFL GQVRLSNIRY LAELTKFGIV PEHVVFHCLK VSLDDFSRMN
     IEIICNLLEN CGRYLLRNPE TSPRMASFLE TLQRKKSVQH IGQAERMLIE NAVYYVDPPQ
     RPAIEVKERT PMELFIRKLI YGDLTKRNYS KILRHIRRLH WEEKEVVAIL HKVFSKPGKV
     KYGNIHLLAI LLSALYKYHG EFVVGVIDQV TESICLGLES NDFKFNQRRI AEVKYLGELY
     NYRMLEHPVI FDTMYKIMTF GHGGPPVPGR VNPFDLPDDF FRIRLISTIL ETCGMFFNKG
     AAGKKLDFFL SFFQYYIYTK NPLPMDVEFL VQDIFALTRP QWKLASNLEE ASKVFQLAMV
     QDQKTSGVER VVEPEDNDSD VSDDEDGMVP DEDEDDESDD DGGGEAEDNE QQDNTSRYNS
     ESEEEEIVVT RQQEEVDPEE EAEFEREFAK MMAESLDSRK FERKQQFDLP LPIKLKPRES
     TAVGESSTAN EAGPSEAPPS GEKMAFSLLT KKGNRQQTRT VELPSDSHFA IAMKKKQQAE
     KEEQQRIKNL VLNYDLREND DYEGNEKLNA HHHNRSDLRL NKERGGQRVR KLQLSDVDWT
//