ID G4UZ09_NEUT9 Unreviewed; 1035 AA.
AC G4UZ09;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=NEUTE2DRAFT_132749 {ECO:0000313|EMBL:EGZ68093.1};
OS Neurospora tetrasperma (strain FGSC 2509 / P0656).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=510952 {ECO:0000313|EMBL:EGZ68093.1, ECO:0000313|Proteomes:UP000008513};
RN [1] {ECO:0000313|EMBL:EGZ68093.1, ECO:0000313|Proteomes:UP000008513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain FGSC 2509 / P0656 {ECO:0000313|Proteomes:UP000008513};
RX PubMed=21750257; DOI=10.1534/genetics.111.130690;
RA Ellison C.E., Stajich J.E., Jacobson D.J., Natvig D.O., Lapidus A.,
RA Foster B., Aerts A., Riley R., Lindquist E.A., Grigoriev I.V., Taylor J.W.;
RT "Massive changes in genome architecture accompany the transition to self-
RT fertility in the filamentous fungus Neurospora tetrasperma.";
RL Genetics 189:55-69(2011).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|ARBA:ARBA00002677,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR EMBL; GL891269; EGZ68093.1; -; Genomic_DNA.
DR AlphaFoldDB; G4UZ09; -.
DR STRING; 510952.G4UZ09; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_1_1; -.
DR OMA; RGSWDGD; -.
DR Proteomes; UP000008513; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000008513};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 20..47
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 66..107
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 127..168
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 169..200
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 722..961
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 413..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1035 AA; 112305 MW; 67500866568EDBF0 CRC64;
MHLIKPSWLS HSGEQKDFEV YSCHVSPDGK RLATAGGDGH VRVWSVEAIF NSHDRNYTKP
RQLCHMSHHL GTIHSVRFSP NGRYLASGAD DKIICIYHLD SNPPSHTSTF GTNEPPPVEN
WKTYKRLVGH DNDVQDLAWS PDNSLLVSVG LDSKIVVWSG HTFEKLKTLA VHQSHVKGIT
FDPANKFFAT ASDDRTIKIF RYTAPAPNAT QHDMVNNFIL ETSISVPFKH SPLTTYFRRC
SWSPDGNHIA AANAVNGPVS SIAIIERTGW DSEINLIGHE APTEVCMFSP RLFYTQKPDE
NSNANGAASP GLVTVIASAG QDKTLTIWNT NTSRPVLIVQ DIASKSISDL AWTPDGQTVF
AASLDGGVIA AQFETGELGW VAKSEENDKA LQKYGGSRKG MGTAEDVDGL HLENHSKEKE
LRGAESRMGA LMGDPGPAQK ETATTTNGVK PAGKAADTNG TTTPAPPEKP EEESADKTAE
RIAELKSRVT ITKDGKKRVA PLLVSSSGTG LSSLPQAQLV GASSTKPVQS DTPQTILDLS
KPYDGLPRGG IAAMLLGNKR KAVIVEDEEE EEPSAKRSAT GPVPIVVNGV EGLEPAPLSA
PAHGLVPTPE FLRPAVISPN IAYSQVRLAV PKIRSHILRP LERGVLQEET SLEDATKVPE
NVVLEAKNPA HIREPARITA TKRGALLWQD FLPRAIILVA GSKHFWAAAC EDGTLHTWSP
AGRRLMNAIM LESQPVILEA RDSWLLCVTA VGLCHVYNIK TMSSPHPPVS LAPILDIAMT
SLSPHGATPA PGVTSAHLNS SGVIVATLSN GDGFYYSTSL YAWQRLSESW WAVGSQYWNS
NDSSVSALQT TAVGPVSGAK NGEGEANVSA GIIPYLERHT TTEFLLKGRA YTLQRLVKAL
LARDGFENFE SSVSIAHLEN RIAGALALGA REEFRLYLFM YAKRIGAENQ KIKVEELLNS
LIGGVLQDAD DGEGWFSKQD KLCGWDRKDL LQGVVLILGK FRDLHRLTVQ YARILDMTLG
DEEKETTDEG MEVED
//
