ID G4V0Q2_NEUT9 Unreviewed; 1169 AA.
AC G4V0Q2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Nitrite reductase {ECO:0000313|EMBL:EGZ68542.1};
GN ORFNames=NEUTE2DRAFT_118535 {ECO:0000313|EMBL:EGZ68542.1};
OS Neurospora tetrasperma (strain FGSC 2509 / P0656).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=510952 {ECO:0000313|EMBL:EGZ68542.1, ECO:0000313|Proteomes:UP000008513};
RN [1] {ECO:0000313|EMBL:EGZ68542.1, ECO:0000313|Proteomes:UP000008513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain FGSC 2509 / P0656 {ECO:0000313|Proteomes:UP000008513};
RX PubMed=21750257; DOI=10.1534/genetics.111.130690;
RA Ellison C.E., Stajich J.E., Jacobson D.J., Natvig D.O., Lapidus A.,
RA Foster B., Aerts A., Riley R., Lindquist E.A., Grigoriev I.V., Taylor J.W.;
RT "Massive changes in genome architecture accompany the transition to self-
RT fertility in the filamentous fungus Neurospora tetrasperma.";
RL Genetics 189:55-69(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- COFACTOR:
CC Name=siroheme; Xref=ChEBI:CHEBI:60052;
CC Evidence={ECO:0000256|ARBA:ARBA00001929};
CC -!- PATHWAY: Nitrogen metabolism; nitrate reduction (assimilation).
CC {ECO:0000256|ARBA:ARBA00005096}.
CC -!- SIMILARITY: Belongs to the nitrite and sulfite reductase 4Fe-4S domain
CC family. {ECO:0000256|ARBA:ARBA00010429}.
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DR EMBL; GL891269; EGZ68542.1; -; Genomic_DNA.
DR AlphaFoldDB; G4V0Q2; -.
DR STRING; 510952.G4V0Q2; -.
DR eggNOG; KOG1336; Eukaryota.
DR HOGENOM; CLU_003291_0_0_1; -.
DR OMA; MWGGVTN; -.
DR UniPathway; UPA00653; -.
DR Proteomes; UP000008513; Unassembled WGS sequence.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0008942; F:nitrite reductase [NAD(P)H] activity; IEA:InterPro.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.90.480.20; -; 1.
DR Gene3D; 1.10.10.1100; BFD-like [2Fe-2S]-binding domain; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1.
DR Gene3D; 3.30.413.10; Sulfite Reductase Hemoprotein, domain 1; 1.
DR InterPro; IPR007419; BFD-like_2Fe2S-bd_dom.
DR InterPro; IPR041854; BFD-like_2Fe2S-bd_dom_sf.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR005117; NiRdtase/SiRdtase_haem-b_fer.
DR InterPro; IPR036136; Nit/Sulf_reduc_fer-like_dom_sf.
DR InterPro; IPR012744; Nitri_red_NirB.
DR InterPro; IPR006067; NO2/SO3_Rdtase_4Fe4S_dom.
DR InterPro; IPR045854; NO2/SO3_Rdtase_4Fe4S_sf.
DR InterPro; IPR006066; NO2/SO3_Rdtase_FeS/sirohaem_BS.
DR InterPro; IPR017941; Rieske_2Fe-2S.
DR InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR NCBIfam; TIGR02374; nitri_red_nirB; 1.
DR PANTHER; PTHR43809; NITRITE REDUCTASE (NADH) LARGE SUBUNIT; 1.
DR PANTHER; PTHR43809:SF1; NITRITE REDUCTASE (NADH) LARGE SUBUNIT; 1.
DR Pfam; PF04324; Fer2_BFD; 1.
DR Pfam; PF01077; NIR_SIR; 1.
DR Pfam; PF03460; NIR_SIR_ferr; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF00355; Rieske; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00397; SIROHAEM.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF50022; ISP domain; 2.
DR SUPFAM; SSF56014; Nitrite and sulphite reductase 4Fe-4S domain-like; 1.
DR SUPFAM; SSF55124; Nitrite/Sulfite reductase N-terminal domain-like; 1.
DR PROSITE; PS00365; NIR_SIR; 1.
DR PROSITE; PS51296; RIESKE; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nitrate assimilation {ECO:0000256|ARBA:ARBA00023063};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008513}.
FT DOMAIN 935..977
FT /note="Rieske"
FT /evidence="ECO:0000259|PROSITE:PS51296"
FT REGION 991..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1013
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1169 AA; 126807 MW; FB3F66FB0EA405C4 CRC64;
MASSTSPSPS PESTTPPRKR IVVVGLGMVG IAFIEKLIKL DTQRQYEIVV VGEEPHVAYN
RVGLTSFFSH REVEQLYLNP LEWYKQHLQT SSLTHHLSTT ALSLSPATKS LTISPPPSTP
SLTTLPYDHL ILATGSRALL PTSTPGHDAS GVFVYRTIAD LQSLITWSSD TQIKGSTGVV
VGGGLLGLEA AKALMDLQVF GRVVVIERNG WVLSRQVDGE AGALVLEGVR GLGVEVLTRK
RVKEVECDHG EDEGQKEKKR VKGIRFEDGE YLACSTICFA IGIKARDELA RQAGITCAER
GGGGIVVDDS LQTSAADVYA IGECASWKGQ TFGLIGPGVE MADVLAFNFT QAHLHTPRVF
KRPDLSTKLK LLGVEVASFG DFFADRDGPK ELPPKLRREL KKSGGKAEVK ALTYKDPFLS
VYKKYIFTSD GKYLLGGMMI GDTTDYVRLV PLVKTHKELD IPPSQLILGA KKSGDDNGDD
DLPDDTQICS CHNVTKADLV APLKSGECTS LGDLKSCTKA GTGCGGCMPL VTSIFNRTMA
SLGTEVKNNL CPHFPEYSRA DLYNIISVKR LRTLPDVMRE AGADADSLGC EACKPAIASI
FASLWNDHVM SPAHHGLQDT NDRFMGNIQR NGTFSVVPRV AAGEITPEKL IVIGEVAKEY
NLYTKITGGQ RIDMFGARKQ DLLNIWKKLV DAGMESGHAY AKSLRTVKSC VGTTWCRYGV
GDSVGMAVRL EERYKGLRGP HKIKGGVSGC TRECAEAGNK DFGLIATEKG FNILICGNGG
TTPKHSVLLA KDVPPTNVIP IIDRFLMFYI RTADKLQRTA RWLEALPGGI DYLKEVILED
RLGICASLEA QMQELVDSYF DEWAEALNNP AMQERFKQFA NTDEGQPPME VEIDRGQERP
VMWPREDQGG SAKADFKGLR DKWSSTTWQP VLEASYFQGA DDLPNGISAS IKRGDTQLAV
WRIKGKYYAS QQMCPHKRTF ALSDGFVGTD PSPSSCSSTA LPPSPPSTPP RSSSPVTSSP
QSPTSSATPA TTTSSSCTTN PSGPSSPWIS CPFHKRNFSL TSGSCKNDNE LSIATFDVEE
RDDGMVYIKL PPVDELDREL GTKKWMVKRG EAGEGQFREL DELNKSKGVE GKKGRRGRKP
GASEAGKEVG KKLVEAVGGG GCGGPGLEW
//
