ID G4VBW4_SCHMA Unreviewed; 906 AA.
AC G4VBW4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Putative alpha-actinin {ECO:0000313|WBParaSite:Smp_014780.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_014780.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_014780.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_014780.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
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DR RefSeq; XP_018650012.1; XM_018795729.1.
DR AlphaFoldDB; G4VBW4; -.
DR STRING; 6183.G4VBW4; -.
DR EnsemblMetazoa; Smp_014780.1; Smp_014780.1; Smp_014780.
DR GeneID; 8347322; -.
DR KEGG; smm:Smp_014780.1; -.
DR WBParaSite; Smp_014780.1; Smp_014780.1; Smp_014780.
DR CTD; 8347322; -.
DR eggNOG; KOG0035; Eukaryota.
DR HOGENOM; CLU_005217_1_1_1; -.
DR InParanoid; G4VBW4; -.
DR OMA; FAIQDIQ; -.
DR OrthoDB; 2872403at2759; -.
DR PhylomeDB; G4VBW4; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd21214; CH_ACTN_rpt1; 1.
DR CDD; cd21216; CH_ACTN_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF442; ALPHA-ACTININ, SARCOMERIC-RELATED; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00435; Spectrin; 3.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 30..134
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 143..249
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 745..780
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 801..836
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 543..577
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 660..697
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 906 AA; 104943 MW; 3117EB81BB5F1BBE CRC64;
MAIYDYEGPV DDDDDVESNK DVPIDPAWEL QQKKTFTAWC NSHLRNVNKQ INVIENDFRD
GVMLIKLLEV ISGESLPSPE RGMMRFHKIA NVNKALDFIQ SKGVKLVSIG AEEIVDGNPK
MTLGMIWTII LRFAIQDIQI EDSSAKEGLL LWCQRQTAPY KNVCVENFHT SFKDGLAFCA
IIHRNRPHLI DYSQLKKGDH VKNLNLAFEI AEKHLDIPKM LDPEDMASRK NCDEQSVMAY
LSSYYHVFSG SHKTDIAATR IANNLRMIRE NQNLEECYET NSTTLLSWIN MKLREFGQRD
PQTSVSAVEG LQQKFRLYYR QEKPSKLQEK ARLETTYNTL QTRLRLNNKS PYVPANGHLI
TDVAKNWSSL EQADKIYEEW LLEELQRLER LEYLAKKFEV KCSTHEAWTN GKPEALASND
FRSAMLSEMR AFQKKHEAFQ SDMTAHHARI EHIQALTEEL NKLNHFNINA FNQRCDTIIT
TWDEMRKLSS QREREISKAL TALEEIDQLH LDFAKRAAPF NNWMEQTEED LRDTFIVHTM
PEVERLITAH QAFENTLDEA ENESRQLQLC AQKVEEIASE YKLVNATQNP YTNIKPHELP
QRWNMIRELT KKRSTLLNRE RERQLANEKL RREFAQKAEA FNSSIETHRA EIVKVSMESH
SSLEDQRNHL QKLEEELNRH QDKLNELEHV NQALEDAYVF ENPYTVYSMP TLRVAWEQLF
TLLHYSVNEI DNQILTRDSR GLTAEQMNDL RTCFKHFDKN NTGRLEPNEF KACLVSLGYN
FRDDIKNSLP NLSSGSRGSV CAETDFSRIV NEVDPGHTGY ISFDAFLNFM TRDNVDEATE
EQLIQSFKTL GGDKGYITAQ DIKERLSAGD AEYCLQNMPV LNGPRGDSGA LDYERFAYSI
CGRKPT
//
