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Database: UniProt
Entry: G4VHJ6_SCHMA
LinkDB: G4VHJ6_SCHMA
Original site: G4VHJ6_SCHMA 
ID   G4VHJ6_SCHMA            Unreviewed;      1415 AA.
AC   G4VHJ6;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   13-FEB-2019, entry version 41.
DE   SubName: Full=Putative inositol 1,4,5-trisphosphate receptor {ECO:0000313|EMBL:CCD79859.1};
GN   ORFNames=Smp_151860 {ECO:0000313|EMBL:CCD79859.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1] {ECO:0000313|EMBL:CCD79859.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Puerto Rico;
RA   Aslett M.;
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CCD79859.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Puerto Rico;
RA   Protasio A.V., Tsai J.I., Babbage A., Nichol S., Hunt M., de Silva N.,
RA   Anderson T.J.C., Clark R.C., Davidson C., Dillon G.P., Holroyd N.,
RA   LoVerde P.T., Lloyd C., McQuillan J., Oliveira G., Otto T.D.,
RA   Parker-Manuel S.J., Quail M.A., Wilson A., Zerlotini A., Dunne D.W.,
RA   Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of
RT   the human blood fluke Schistosoma mansoni.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican;
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of
RT   the human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
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DR   EMBL; HE601627; CCD79859.1; -; Genomic_DNA.
DR   RefSeq; XP_018652463.1; XM_018797419.1.
DR   EnsemblMetazoa; Smp_151860.1; Smp_151860.1:pep; Smp_151860.
DR   GeneDB; Smp_247340.1:pep; -.
DR   GeneID; 8354994; -.
DR   KEGG; smm:Smp_151860; -.
DR   CTD; 8354994; -.
DR   InParanoid; G4VHJ6; -.
DR   KO; K04958; -.
DR   OrthoDB; 94996at2759; -.
DR   PhylomeDB; G4VHJ6; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Receptor {ECO:0000313|EMBL:CCD79859.1};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904}.
FT   DOMAIN      110    163       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      171    233       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      241    297       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED      662    682       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1415 AA;  163543 MW;  1411A845FF5B5972 CRC64;
     MLMIFGAEIE NKVELLHFGD QVTFYSNDED GGLLCMEGQI SNKPNVTRLN SVGNFTSSLT
     RDCRFFILAM QKYLNENCLE NETRFRPDKL IEESGCDNEQ NSKMQRRLQE SLVYYGNIIQ
     LLHVKSNKIL RAKKELSPEF KDASVRFTLE EYQGDESWFI IQPSYKHKQI GDPVVIGDKV
     TLFACRAGCA LNIKQLNSNP KQHKLMSDTD PHGINNNNNS DNNNNTSWQI NLYLSYQDNL
     EHILKGGDVI RLFHSEAEKF LTCDEYENEL YVFLRTTFRA ATTTAKSSKA LWEVEVIHSD
     CRRTGAGHWN SLFRLKHLIT GLYLCPKIIK INNKSGEQGA FSKQEQDDGC IESFLTLSKE
     PTYETVFEMD STSHYKESDG FIPNNAFVRI CHTASRMWIK ASEILIDTDA DKPIMYKIIK
     ILNSKMISNL PKQSTSIVNN HLINSNILIW KPDISLLSIL HETQSNTMDT QQQNVYLDEK
     NEILAWQTVG NLCYRILTLS QHGYRKNQEY LAQYLNLMQT HIGLGIRASE TITALLHNNR
     QLLEKRVGEQ EVSAFVSLVR DNIEARFLNY LSALCSSCGV AIPVTQELIC HQLLSENNED
     LLVETCNKRF IDSDSNYSTD IITLIWKQTC LIDDDFWKNL NSNLILNQSE FNQTQKYLQF
     NLNVLNDIIN QSKQELNEKS KQITLYCLIL DYYQAQIDLF ALLCQERQYI AINYLSLKLS
     IYLLLKCMRN ERLRPSLRAS FTRLLLNLHV DRDPQELHQP IQYARLWSTL GTKSDVFNYE
     KANSSTNEQG NFTTDFMEIK NFVNDYLDNM LSSGCYLSEP GYINLTNEVI ILSKNLVFFG
     LYNIKELLLL GQKLVFMLNQ LGSTNDFNSN IYKSRAFREG EQTLPTLGRT RAVKQPEACS
     NNLELEDLEK EQTLGKKFLV ITWILYLMYL FFQSNLSQNL EMNDSPKYNS TEDKLTILNV
     DGYHGQLLIG VLARLCISTN VELKLKSLQL LFRHFSQQEE LINKLKQVQL LVSDTGIKIY
     RQLKQHLDTL RGLIEKSELW MHDKSCMVMS NNNNNNNINN IQEQKSTNVI DVLSIEISTQ
     INNRILRTMD KSLSSSFPFE QIQQLLRHLG VHTILKELLN IRFKLCSMFD DTLFLMNSFS
     RVRNILDSLL LTITYSNSSA WSVIKFSDNT SKQDLLFNLK FFHLLNILLT EENDILVKKY
     RKWFKLSELI KVIIHPVTKC HNLCYLRNVY MENLANFCSS TDFKNNFVIQ YSESLSFLWR
     DITEELDKNC NSPSCYLMHK LMQINNDPLL GPASIECSQM IMCTIPSESL SVLPEFSYRQ
     DIFMTNSYAD LRKTLEDKNT STSGITSDDL IDSGLQDENS LDSNMFETVS VKTVQKCHMS
     NNLSEIQMSQ PMDDTNRSLS QNFAKNIERQ FNVSE
//
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