ID G4VJU5_SCHMA Unreviewed; 488 AA.
AC G4VJU5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Origin recognition complex subunit 4 {ECO:0000256|ARBA:ARBA00019083, ECO:0000256|PIRNR:PIRNR007858};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_042210.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_042210.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_042210.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. {ECO:0000256|PIRNR:PIRNR007858}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR007858}.
CC -!- SIMILARITY: Belongs to the ORC4 family. {ECO:0000256|ARBA:ARBA00005334,
CC ECO:0000256|PIRNR:PIRNR007858}.
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DR RefSeq; XP_018652300.1; XM_018797238.1.
DR AlphaFoldDB; G4VJU5; -.
DR STRING; 6183.G4VJU5; -.
DR EnsemblMetazoa; Smp_042210.1; Smp_042210.1; Smp_042210.
DR GeneID; 8354319; -.
DR KEGG; smm:Smp_042210; -.
DR WBParaSite; Smp_042210.1; Smp_042210.1; Smp_042210.
DR CTD; 8354319; -.
DR eggNOG; KOG2228; Eukaryota.
DR HOGENOM; CLU_007115_0_1_1; -.
DR InParanoid; G4VJU5; -.
DR OMA; ETKFRHH; -.
DR OrthoDB; 230201at2759; -.
DR PhylomeDB; G4VJU5; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000808; C:origin recognition complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR016527; ORC4.
DR InterPro; IPR032705; ORC4_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12087; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR12087:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF14629; ORC4_C; 1.
DR PIRSF; PIRSF007858; ORC4; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR007858};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR007858};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR007858};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854}.
FT DOMAIN 247..444
FT /note="Origin recognition complex subunit 4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14629"
SQ SEQUENCE 488 AA; 55433 MW; 88E492A6DA9B7F83 CRC64;
MDLICDVLRI KLRGNQHRLL YFDKELKYLQ DLISSTVSKG ESSSILIIGR RGVGKHHLIK
EAIKKAKEDP NIGSGISEVY LNGLVHTDDR SAMKSLAKQL HNESLLSNLV QPDRNSTSDF
HNSMINLPFS QQLNSFLNEV RQNHGTRKAI LIVLSEFDLF ALHHNQLLLY NLFDCCQSPE
SRICIIGLTC RLDIMELLEK RVKSRFSHRQ IYLTSPGAPI ENTDSYASNN NDNHDNSRSE
PFKRFCEICK HLLSVDIHDL LPQLSPLLCK LNSKEHRELE LSIKSWNHHI EKLMLDEIVI
DSLRQAWSIS VSIKRLINLL IPIVASLGPE HDRIEPVQFI ESLCTLQQDS KLTALKGCSV
LELFLITAMV KLQDMNVGKP VNFESLYSEY LKFCRSNCPG HLYDKPVVMK ALDNLIDFEL
IISGKAAVTA STGLSTAGSN NKAIWSSSAL PNYRPLFCYV DNDTLTACLD TYPNCPVELR
YWIHSRTF
//
