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Database: UniProt
Entry: G4VNH1_SCHMA
LinkDB: G4VNH1_SCHMA
Original site: G4VNH1_SCHMA 
ID   G4VNH1_SCHMA            Unreviewed;       540 AA.
AC   G4VNH1;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 71.
DE   RecName: Full=Branchpoint-bridging protein {ECO:0000256|RuleBase:RU367126};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_021540.1};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of the
RT   human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN   [2] {ECO:0000313|WBParaSite:Smp_021540.1}
RP   IDENTIFICATION.
RC   STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_021540.1};
RG   WormBaseParasite;
RL   Submitted (DEC-2018) to UniProtKB.
CC   -!- FUNCTION: Necessary for the splicing of pre-mRNA. Has a role in the
CC       recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract
CC       and the 3'-splice site at the 3'-end of introns.
CC       {ECO:0000256|RuleBase:RU367126}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367126}.
CC   -!- SIMILARITY: Belongs to the BBP/SF1 family.
CC       {ECO:0000256|RuleBase:RU367126}.
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DR   RefSeq; XP_018653738.1; XM_018799868.1.
DR   AlphaFoldDB; G4VNH1; -.
DR   STRING; 6183.G4VNH1; -.
DR   EnsemblMetazoa; Smp_021540.1; Smp_021540.1; Smp_021540.
DR   GeneID; 8341134; -.
DR   KEGG; smm:Smp_021540; -.
DR   WBParaSite; Smp_021540.1; Smp_021540.1; Smp_021540.
DR   CTD; 8341134; -.
DR   eggNOG; KOG0119; Eukaryota.
DR   HOGENOM; CLU_016864_5_1_1; -.
DR   InParanoid; G4VNH1; -.
DR   OMA; RIMDEDH; -.
DR   OrthoDB; 1397at2759; -.
DR   PhylomeDB; G4VNH1; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   ExpressionAtlas; G4VNH1; baseline.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0045131; F:pre-mRNA branch point binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR   CDD; cd22382; KH-I_SF1; 1.
DR   Gene3D; 6.10.140.1790; -; 1.
DR   Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR   InterPro; IPR045071; BBP-like.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR032570; SF1-HH.
DR   InterPro; IPR047086; SF1-HH_sf.
DR   PANTHER; PTHR11208; RNA-BINDING PROTEIN RELATED; 1.
DR   PANTHER; PTHR11208:SF45; SPLICING FACTOR 1; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF16275; SF1-HH; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU367126};
KW   mRNA processing {ECO:0000256|RuleBase:RU367126};
KW   mRNA splicing {ECO:0000256|RuleBase:RU367126};
KW   Nucleus {ECO:0000256|RuleBase:RU367126};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW   Spliceosome {ECO:0000256|RuleBase:RU367126};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367126};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU367126}.
FT   DOMAIN          149..242
FT                   /note="K Homology"
FT                   /evidence="ECO:0000259|SMART:SM00322"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          81..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          474..494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..401
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   540 AA;  58065 MW;  972086C8919D15B3 CRC64;
     MSKRILAITD GSSSRSRRRS RSPEKSPDSA PRKRKSRWSA AETDRIFIPG MPTQLPPNLT
     PQQERVYIIQ LQIEDMSRRL KSGDLGIPKN PEDRSPSPEP IYSSDGKRLN TREYRTRKKL
     EDDRHALVQQ LMEINPEYKP PSDYKAPQNR ITDKVFIPQD NHPDINFVGL LIGPRGNTLK
     ALEKDTGAKV IIRGKGSVKE GKVGRRDGLP LPGEDEPLHA FISAPSAECV DKAVKKINEI
     IRQGIEIPES QNDLRRAQLR ELALLNGTLR EHEGLMKLRA MAEAQSIATN KIQCGICGGA
     GHLSTDCKAL LGGQAYLDQL NANPSERAKM DSEYTALMAE LGVGGSQGLP PGLRGFNALQ
     PQPTRPTRQP PPPGVASFDD DDDADAGTNC TSATTTSTVT TTVSSPNQYA FALPPPPPPP
     SQYTPMVTPV TPWATPAVVP PMPGYPSTAA YPTSGVPAVA GAYSEVTNGG SSLNHWHPSV
     PGSASWSDSS SQVPAGVPVP GTAMVPPYYL PTPTDYWAGY TGGYAASVPN PPPPPPPPGV
//
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