ID G4VNH1_SCHMA Unreviewed; 540 AA.
AC G4VNH1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=Branchpoint-bridging protein {ECO:0000256|RuleBase:RU367126};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_021540.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_021540.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_021540.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- FUNCTION: Necessary for the splicing of pre-mRNA. Has a role in the
CC recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract
CC and the 3'-splice site at the 3'-end of introns.
CC {ECO:0000256|RuleBase:RU367126}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367126}.
CC -!- SIMILARITY: Belongs to the BBP/SF1 family.
CC {ECO:0000256|RuleBase:RU367126}.
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DR RefSeq; XP_018653738.1; XM_018799868.1.
DR AlphaFoldDB; G4VNH1; -.
DR STRING; 6183.G4VNH1; -.
DR EnsemblMetazoa; Smp_021540.1; Smp_021540.1; Smp_021540.
DR GeneID; 8341134; -.
DR KEGG; smm:Smp_021540; -.
DR WBParaSite; Smp_021540.1; Smp_021540.1; Smp_021540.
DR CTD; 8341134; -.
DR eggNOG; KOG0119; Eukaryota.
DR HOGENOM; CLU_016864_5_1_1; -.
DR InParanoid; G4VNH1; -.
DR OMA; RIMDEDH; -.
DR OrthoDB; 1397at2759; -.
DR PhylomeDB; G4VNH1; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR ExpressionAtlas; G4VNH1; baseline.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0045131; F:pre-mRNA branch point binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd22382; KH-I_SF1; 1.
DR Gene3D; 6.10.140.1790; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR045071; BBP-like.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR032570; SF1-HH.
DR InterPro; IPR047086; SF1-HH_sf.
DR PANTHER; PTHR11208; RNA-BINDING PROTEIN RELATED; 1.
DR PANTHER; PTHR11208:SF45; SPLICING FACTOR 1; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF16275; SF1-HH; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU367126};
KW mRNA processing {ECO:0000256|RuleBase:RU367126};
KW mRNA splicing {ECO:0000256|RuleBase:RU367126};
KW Nucleus {ECO:0000256|RuleBase:RU367126};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW Spliceosome {ECO:0000256|RuleBase:RU367126};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367126};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU367126}.
FT DOMAIN 149..242
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 540 AA; 58065 MW; 972086C8919D15B3 CRC64;
MSKRILAITD GSSSRSRRRS RSPEKSPDSA PRKRKSRWSA AETDRIFIPG MPTQLPPNLT
PQQERVYIIQ LQIEDMSRRL KSGDLGIPKN PEDRSPSPEP IYSSDGKRLN TREYRTRKKL
EDDRHALVQQ LMEINPEYKP PSDYKAPQNR ITDKVFIPQD NHPDINFVGL LIGPRGNTLK
ALEKDTGAKV IIRGKGSVKE GKVGRRDGLP LPGEDEPLHA FISAPSAECV DKAVKKINEI
IRQGIEIPES QNDLRRAQLR ELALLNGTLR EHEGLMKLRA MAEAQSIATN KIQCGICGGA
GHLSTDCKAL LGGQAYLDQL NANPSERAKM DSEYTALMAE LGVGGSQGLP PGLRGFNALQ
PQPTRPTRQP PPPGVASFDD DDDADAGTNC TSATTTSTVT TTVSSPNQYA FALPPPPPPP
SQYTPMVTPV TPWATPAVVP PMPGYPSTAA YPTSGVPAVA GAYSEVTNGG SSLNHWHPSV
PGSASWSDSS SQVPAGVPVP GTAMVPPYYL PTPTDYWAGY TGGYAASVPN PPPPPPPPGV
//