ID G4VTC9_SCHMA Unreviewed; 584 AA.
AC G4VTC9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=procollagen-proline 4-dioxygenase {ECO:0000256|ARBA:ARBA00012269};
DE EC=1.14.11.2 {ECO:0000256|ARBA:ARBA00012269};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_068280.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_068280.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_068280.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- FUNCTION: Catalyzes the post-translational formation of 4-
CC hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other
CC proteins. {ECO:0000256|ARBA:ARBA00002035}.
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319}.
CC -!- SIMILARITY: Belongs to the P4HA family.
CC {ECO:0000256|ARBA:ARBA00006511}.
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DR RefSeq; XP_018654586.1; XM_018789110.1.
DR AlphaFoldDB; G4VTC9; -.
DR STRING; 6183.G4VTC9; -.
DR EnsemblMetazoa; Smp_068280.1; Smp_068280.1; Smp_068280.
DR GeneID; 8354649; -.
DR KEGG; smm:Smp_068280; -.
DR WBParaSite; Smp_068280.1; Smp_068280.1; Smp_068280.
DR CTD; 8354649; -.
DR eggNOG; KOG1591; Eukaryota.
DR HOGENOM; CLU_024155_1_1_1; -.
DR InParanoid; G4VTC9; -.
DR OMA; NWEMKDI; -.
DR OrthoDB; 2899308at2759; -.
DR PhylomeDB; G4VTC9; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0004656; F:procollagen-proline 4-dioxygenase activity; IEA:UniProtKB-EC.
DR Gene3D; 6.10.140.1460; -; 1.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR045054; P4HA-like.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR InterPro; IPR013547; Pro_4_hyd_alph_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10869:SF207; P4HA_N DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10869; PROLYL 4-HYDROXYLASE ALPHA SUBUNIT; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR Pfam; PF08336; P4Ha_N; 1.
DR SMART; SM00702; P4Hc; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..584
FT /note="procollagen-proline 4-dioxygenase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030172039"
FT DOMAIN 455..562
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 584 AA; 66246 MW; 8A6FCA4BEF3A47AB CRC64;
MALLSFTVTW LLLFQQKYIN AEYYTAVVDI TKAWRLSQEL VSDLNSYIAL EEGRLNRIRK
VVKVLDSNGS ISDASSTLNQ QNNDLEEYLG NPINAYLTMK RLSSSWKSQL SQLVDNVPNG
FQKGDTDGSD YLNISDAQNT ITMNTIRSRV KQHTDMLPGD NDVSGAVDAI LRLQSTYKLP
ARRLAYGQLI DNLSTPQLSA AQCLEVGRHA YLQGDFEQSE EWFRVAYDRL FDELEEKREV
DAQGTTIAND ETEENGETEP TVGQILDYLA YSLGRQGRYA EALNVTRLLI EEEPTNTRAI
NNEAYYVEQI DRGEGRIGPN PRSQAISKHD QETELYESLC RNENPFPTVP SHHLTCRYYT
PHAFFKIGPV KEETLNPDPR IVMWYDLIFP SEIEKIKELA TPRLRRATVK NPVTGILEIA
FYRTSKSAWL PHSMSEITDQ ISQRIRAVTG LSLETAEDLQ VGNYGLGGHY APHFDFGRKR
EKDAFEVKNG NRIATIIFYL SDVQAGGATV FNRIGTRVVP KKGAAGFWFN LLPNGEGDLR
TRHAACPVLA GSKWVMNLWF HERGQEFRRP CELERGTVET DDDF
//
