ID G4YYI9_PHYSP Unreviewed; 4577 AA.
AC G4YYI9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Dynein heavy chain {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHYSODRAFT_486395 {ECO:0000313|EMBL:EGZ25107.1};
OS Phytophthora sojae (strain P6497) (Soybean stem and root rot agent)
OS (Phytophthora megasperma f. sp. glycines).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1094619 {ECO:0000313|EMBL:EGZ25107.1, ECO:0000313|Proteomes:UP000002640};
RN [1] {ECO:0000313|EMBL:EGZ25107.1, ECO:0000313|Proteomes:UP000002640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P6497 {ECO:0000313|EMBL:EGZ25107.1,
RC ECO:0000313|Proteomes:UP000002640};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
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DR EMBL; JH159152; EGZ25107.1; -; Genomic_DNA.
DR RefSeq; XP_009520395.1; XM_009522100.1.
DR STRING; 1094619.G4YYI9; -.
DR EnsemblProtists; EGZ25107; EGZ25107; PHYSODRAFT_486395.
DR GeneID; 20656015; -.
DR KEGG; psoj:PHYSODRAFT_486395; -.
DR InParanoid; G4YYI9; -.
DR OMA; IAYEYMK; -.
DR Proteomes; UP000002640; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002640}.
FT DOMAIN 172..743
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1263..1666
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1816..2145
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2319..2432
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2660..2762
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2826..3088
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3102..3459
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3486..3708
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3962..4073
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 4105..4251
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4258..4574
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 3340..3388
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4577 AA; 523707 MW; 427DCD5425806A18 CRC64;
MSTPRMQWVS QRIVETFEPS VTQAEVTEFL ASPGTRKLFN ELLSGKDACK VKLCVSLGNS
IPIRAKCCFF LRTTADGKPV DVQKASDNAI CFGELAPNIL RDLETTISSL FSPLLKAKDE
WGKADADLKN EFMTESEKFA NDLKEALNSM DSGLELRRPD RSILAETLIV YYEEVLKEWC
DVISTYLETN TTNDGKGGNN DQSIDDDGPM GELEYWRRRM QRLTSITEQL KMNEYKDVFA
VLSRTTKSVS DDTKQRIQTL LRRWKQIDIG ITEAANEAKD NVKYLFTLEK FIIPLYNGTP
SSIIDTLPAL MNSIKMIHSI ARYYNTTERM ANLFTKITNQ MITNCKHCVT GGETYEVMWD
KDPEELVRHL DSCLKLNEAY QQQYRVTKDK LFATPKGKQF EFNEMKIFGK FDLFCRRVMK
LIDMFTTIHQ FSSLGQHRLE GMEDLIAKFN SIIREFQYRN HDLLDYKNNR FDRDYVEFNV
RISDLEGLLQ KFINDSFENI TSIEHSLNLL RKFQTILQRE NLKSDLDSKF NVIFQNYGLE
LEHVLQQYEK YKQNPPYPRN LPPVAGNITW SRHLLKRIEE PMKKFESNQN VLASKDAKRI
IRMYNKVART LVAFEYIWYQ AWVQYIDTAK AGLQATLIIR HPEDNKLYVN FDPEILQLLR
EAKCLDRMGI EIPEAAKIVL LQEDKFKNYY NELQYALAEY DRIVTKVIPV TAMLLRPHFN
DMEFKLRPGM ITLTWTSMNI EAYRNHIHSG LQHLEELVTN INDIIENRIE KNMRIVSKTM
LVDLPVDQSF SLDEFVTMQG SNIKRAGALL QGKNVEIENA VEDLLKIIMQ YPLDSHIEGV
SNDEAMKLKK HYNHFMYQAL LHCTKNSLNT IKKRVASRMT STIFTIERPF FEVDVQLSVP
NVQLHPSLDE IQLAINKAAQ TILSCSKELL DWGQSDLSSA VNSSNSNGTD SNGNTTHPNA
GKITFFDRIT KDIEIVRVVL LLTGSVQGLR NNVTEYLCSF KKYEWLWMEQ KDVSYENFLK
KNPELQDFEK KLKSFVEIDE EISSLTPIHN IGALSLNTRN IKLQLKHENS QWKLKFSDNL
HNQARRKMES LTEYFRSTMG KLNRKVVDLD SLRFVMNLLK EVRARESGIN MEINPVLDMY
EMLEYYLPDG FMEKEEMDQK SVLRSNWRKL IHHAETRTDE LSKTQAGFKR GLLRDIKELI
VDVKHFREDY LANGPMVIGI PPVEAVERLN RYKEEYKIRE RKHELYLSGE ELFALPKTTY
PELEMTKKEL QLQDKLFGLY TDVLSTIEEW KQIPWLSVAE RVQSMTEKVD AFSLRCKKMP
GKLREWEAYT DLKKMIDDFT DVLPLLQELS KESIKPRHWE AVMAITKTQL DVTAPDFKLQ
ALMDANIVEY KSEIEEVTDG ADKQLKIEIQ LAEISARWET EEFQFQDWKS RNVPILKAVV
PVVEELEETQ MNLQTMLSMR HVIPFKDVAQ GKLEQLSDTS ETLERWIKVQ MLWCSLESVF
TGGDIAKQMP VEAKKFQKVD KDWAKIMAKS EEIKNVVACC SSELLKSCLP TMYSELEKCQ
KSLEGYLEQK RNKFPRFYFV SNPGLLMILS QGSDPLSMNE HYEKVFDSIE RVYHDKKDKT
LIHTMVSGVE EVRFSQIVKA QGNIEDWLAT LLRGMQITMK DICRQSAMDI GVVGNDLKRL
REFVDRYVAQ FALLGIQMMW TTDIQTALEQ CRAKKNIMKD TSTKQAMVLT ELSNWCLGDL
GSKENRIKIE TLVTIHVHQR DVMTDLATLY KQKKISDPND FEWLKQARFY WRPGNSDEFN
ADGACVISIT DVDFNYQFEY LGSKERLVVT PLTDRCYITL AQALGMYFGG APAGPAGTGK
TETVKDLGRT LGIYVVVTNC TDQQKYTDCA KIFKGLCQGG LWGCFDEFNR IQLPVLSVVA
QQVLAIQNAK KTGTKYFQFP GDPQNILLTQ VCGYFITMNP GYAGRQELPE NLKALFRGVA
MMVPDFEIIM KVKLCSVGYS EYQDLAKKFF ILYNTCKEQL SAQKHYDWGL RNILAVLRSA
GKIKRDNRND LESKLLYQTL RDMNLSKLVA QDVPLFLSLL ADLFPTVQFP PKGSYPELTV
ALQAEIEKQG IVDHPGWFNK VIQLYETQLV RHGIMLVGPT GGGKTKIFDV LMQALTLTTN
IVHKQSKLNP KAIRAAEMYG EVDPMSGEWT TGVFAAMWAK YNNKANKFIM WMTCDGPVDA
IWIEDLNTVL DDNKILTLAN GDRMPMTDNV KLMFEVETLV NASPATVSRA GIVFISDTDL
DWAPVVEAWI RKRPPTHQQV LRDLFMKYMG ENNPLNPGHC FDYLNRNTEG VMTVSRVGQA
SRLYNLMTGL LLGDHGTTLS EDPAKLAIQL EKLYLYCLCW SLGSLLEQED RVKFDEWIRQ
YDDNALLPKC EPGQTVYEYF VDPQTWEWKL WRPAKWEYPK GAKQLDFSNL LVPTMDSVRT
LYLIENLHKQ RKPVLMVGGP GTAKTSSALM FFNDLSPDIM MIKRVNFSSA TTPFMFQNAV
ESELDKRGGK SFGPPGGKKM TVFLDDLSMP LVNAWGDQPT LEIVRMIIEL SGFCFLSKDR
RGDFKVCEDL QYVGAMGHPG GGRNDIPNRL KRQFYLFNLI LPSLTSIDDI YGQMLAGRFD
PETYSKDTLS VVNKLTRATI DLWNFMKAKL LPTPAKFHYI FNMRELSRVF QGILLTPPET
FTSGGGIRVT QGKLAKMDPG QVVLLTWKHE CARVFCDKLT NHKDKDIFNA YMRELIKSHY
GDSLEEFCRQ QYSMVNFLRD PEEDEEGGIA DAALKIYEPG GTVADVRSRV LEFLDKYNTD
FPQRQMRLVL FDDALDHLLR ISRLLEMPRG SALLVGVGGS GKQSLTRLAA YMAGSTIFQI
VLTKTYNTNS FMEDIRTLYK SAGHLRKSTT FLFTDAEIKN EIFLELINSI LMTGEVAGLF
AKDEMMAMTA DLRNSFVKER PGQAESQTNL KQYFTDCVRD NLHVVLCMSP LNAKFAERAR
KFPGLISGPT IDWFLPWPED ALIAVSKGFI QDYPMECDAT TKQALMTHMG MVHRIVTDLC
EEYFQKMRRR VYQTPKSYLS FIESYKKMYN VKLDEIKVKE QRVNLGLKKL IQGAEDVRAM
SIVLADEQVK LEKATEETNT MLQSLQVSSA EAHKEGDQVA QIKAKCEEDA ARISAEKELC
EHDLAKAKPF VEEAETAIDS IKPAHIGEIK KLAKPADIIR LVFDGVLILF KLPLIPVKQV
KLNVAKQEID FFETSFSPYA QSMMSDSNFL KNVQNFGAVG KDMINEETIE LLTPYMELEG
FQPSVAKNAS LAAEGLCTWV RAMKFYHEAS KVVKPKLEAL TIAEGQMEAA NKALNAAEQR
LSKCKERLNE LQQMFEAQMA EKKRIEDGAN ALARKMQQAS DLINGLAGER VRWTDDSNNF
ADLKRRLVGD CAVACAFVSY CGPFNQDFRT YMVQNKFVPD CESRNVPVTV DIDVITFLVD
IGTVGDWNMQ GLPTDSLSIQ NGIMVTRSSR YPLLVDPQGQ ALSWIKNKES ERVPSYGTTS
LNHPKLKDQL EFCMGEGKAL IVAGVEEDID PMLDPVLEKQ IIVKGKSMSI NVSDKNMEFN
PAFSMYFITR LPNPHFGPEL QAKTTVIDFT VTIKGLEEQL LGRVIGKEQK ALEEQLAQVL
EDVNMNTKSL LALDASLLER LTSNTGNLLE DEELIGVLAN TKEKAAEVKD KLIAAADTRK
SINEKREQFR PVATRGSVLY FSVVETSLIN CMYQTSLNQF LALFMKSMDV AEKAALASKR
VANIIETMTY ISYRYINRGL YERDKLTFVL LLTLKILVTD SLLTREEVTL LIRGGAALDI
NSVRRKPFSW ISNEAWLNVI ELSQSCKFFT NLPHEMASNE GMWRRWYEDN EPETVVIPDY
EARLTENEVI GPYYKLLLVR SLRMDRTILT TKEFIRNTQQ MGPRYVEPVT DTIESIFAEM
KAETPVIFLL SIGADPTESI EMLARKQKNP SPAVVSMGEG QEPVALKAIN AAVVNGTWVL
LQNCELGLEL MEQMEDIMLK LTETMDPGFR LFLTALPNDQ FPLGLLQMST KVTNEPPQGL
RAGLLRSYTV MVDQEKLERV ETSQWRQLLF NLCFLHSVVI ERKKFGPLGW GIPYEYNNGD
LSACTIFLEK HLYNGPISWP TLQYMVAEVQ YGGKITDNMD RRLFNFYAEW CLTPDVCSPT
FSYNPAEPIF RLPNDFNYRI PVADNIDDYR HFCHTLPEID SPEIFGLHPN ADLTYRVKEV
NMLLTTLGDT QPKGGGGSSG VSREDVVCEK AKELLDRLPE DYNEDDYKAK INKLGGLTIP
LNIFLFQEIQ RLQRVIAKVR SMLQSLQMAI RGEVVMTEEL SWTLDAIFDA KVPPSWLRTS
VGDEFSWILP TLGLWFSSLI SRDEQNRTWL NTRRPNSFWL TGFFNPQGML TAMKQEVTRK
HSKTDKWALD DVVYHTEVTS FERAEQVRAP PSEGVYIYGL FMDGATWSKA DGTIVESEPK
KLFTSLPVLH VNSMSKDLEA KSRKELYGAV GPFECPCYKY ATRTDRYFVF MVTMKCPPGR
PPRHWGLRGV CLLCNTE
//
