ID G4Z732_PHYSP Unreviewed; 1224 AA.
AC G4Z732;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=PHYSODRAFT_493224 {ECO:0000313|EMBL:EGZ21784.1};
OS Phytophthora sojae (strain P6497) (Soybean stem and root rot agent)
OS (Phytophthora megasperma f. sp. glycines).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1094619 {ECO:0000313|EMBL:EGZ21784.1, ECO:0000313|Proteomes:UP000002640};
RN [1] {ECO:0000313|EMBL:EGZ21784.1, ECO:0000313|Proteomes:UP000002640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P6497 {ECO:0000313|EMBL:EGZ21784.1,
RC ECO:0000313|Proteomes:UP000002640};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; JH159153; EGZ21784.1; -; Genomic_DNA.
DR RefSeq; XP_009524501.1; XM_009526206.1.
DR AlphaFoldDB; G4Z732; -.
DR STRING; 1094619.G4Z732; -.
DR EnsemblProtists; EGZ21784; EGZ21784; PHYSODRAFT_493224.
DR GeneID; 20656929; -.
DR KEGG; psoj:PHYSODRAFT_493224; -.
DR InParanoid; G4Z732; -.
DR OMA; PRNMVSH; -.
DR Proteomes; UP000002640; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 86..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 821..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 854..874
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 886..905
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 937..956
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 968..986
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 360..495
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 1046..1174
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 556..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..621
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1224 AA; 136524 MW; 65ACC7F31166B138 CRC64;
MPSLGTIQPM DALNASLVPA PAVPRQKTAV EPMTTRNSIS NKVLQSFDKF QTSQVVPEEK
RSRESSVSRA TAVSEFILFL KVMDQVAIHH ITLYFININT LAVILKMEKS FAKYYASSQR
KLYLRGLLTL IGFMISTFVY DYLVLWEDYG VGANATADGT VSTKLPKFTI VVVLKLAIVL
PLLLLTFFRA RKHPYHEDVK LTWLCICVVA CYPVVYNKIT NDYGVSWVCL VIMYVYSCTP
IRFFPVSIFC LGYLATYVVV MLAYVPGSAS SSSSSSRQEI ANETLYACLF FFLILLPSQS
REFAIRVSYM SELMVLLQQE QLKMEETRSK ALLNSMLPES IVVQLQCGRE LIADEYPEAT
VLFAEVCDFD LFSSKLQPQQ VVELLNILFY KFDKLVDVHH VHKVETIGAV YMVVGGCPDV
IQNHAELVAN LALDMIRCIP EVSAKIARKP WGNMVTNLNI RVGINTGGLM AGVVGIRNPR
FKLFGDTVNV ASRMETTNLP GQIQITEATH NAIYHKFHTA LRGKVFVKGR GDMDTYFLRG
KDGYIVPPAS VVSREHEGAG EVVADDAPSG SNSPTSGRRR TSRMPGSSIN DIPEHKNDAP
AFTPTLAPPT NSNPPTEDIP SRPTTPKAAN ARQPRRASRM TLDSSNKQKT IANLLALAPP
AVRNPSIMQL PEGTKLPTIP QSVKENSENA STTPGASPSQ SLLALADQPP SPSAAARVSH
RRGTVSALKG HSLSQIATVR RSLFRENIFD IVEDIDANGE PECDENAVFS TTIMTLPKGL
TRMEVLFRVH GNRTGFRSLT KEAYEFEESY RLENRMRWLR FLRLSVTVFL VLKPFLTLYQ
TVRLSTIRSF DESQLIFLLN FCIMYPGMLA FLLHTFSPTF SSWEQLESVV VISVVAVILC
AESLATNSLG HAYMSALALY QCYFANVSFL LRVINGFEIL TLYLVANLLI APYFGWEINA
TQLRVLRNAL YIFMFFAGQA WVVFNSEFKQ RINHYRDITL NSQKQKLVEE EARITKLLLN
LLPETIVHKL KEDPQTTIAD FFDNVTVLFT DMVNFTAYSS KVSAMELVQF LNDMYTRFDT
IAEREVLYKV EIIGDAYFVV GGCPIVSTNN ALAVVTAATD MFAVLPLLRR NCGVPDLNIR
IGVHSGPVLA GVVGSKDPRY HLFGETVSIA HFLESSGVPG RIHISESTWA SMNKETPGHG
FKVEYHTLLS ISGSSKKLRT YFVL
//
