ID G4ZEF5_PHYSP Unreviewed; 2396 AA.
AC G4ZEF5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN ORFNames=PHYSODRAFT_315234 {ECO:0000313|EMBL:EGZ18420.1};
OS Phytophthora sojae (strain P6497) (Soybean stem and root rot agent)
OS (Phytophthora megasperma f. sp. glycines).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1094619 {ECO:0000313|EMBL:EGZ18420.1, ECO:0000313|Proteomes:UP000002640};
RN [1] {ECO:0000313|EMBL:EGZ18420.1, ECO:0000313|Proteomes:UP000002640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P6497 {ECO:0000313|EMBL:EGZ18420.1,
RC ECO:0000313|Proteomes:UP000002640};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JH159154; EGZ18420.1; -; Genomic_DNA.
DR RefSeq; XP_009527478.1; XM_009529183.1.
DR EnsemblProtists; EGZ18420; EGZ18420; PHYSODRAFT_315234.
DR GeneID; 20643825; -.
DR KEGG; psoj:PHYSODRAFT_315234; -.
DR InParanoid; G4ZEF5; -.
DR OMA; QHGETIC; -.
DR Proteomes; UP000002640; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 3.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 4.
DR Gene3D; 2.60.120.10; Jelly Rolls; 4.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 3.
DR Pfam; PF00520; Ion_trans; 2.
DR SMART; SM00100; cNMP; 3.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 4.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 39..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..782
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 852..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 877..906
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1312..1330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1539..1563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 473..535
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 980..1080
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1491..1591
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 2162..2276
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 2396 AA; 273146 MW; 82369C377A9EACE0 CRC64;
MPHRKVRSLL KVCRRLYRRG SRPVSRLYKR LPWTTRQTIN LTISLYAALY IFLTVPFRIA
FYYNPFQHEE QEGVHRWTEE LSIFTPLDLV ADVIGLVEFI GFYRVWRDSF SQLSEEVSFE
LGKKLTRDAN RLKMPKTLSR TASGNALRTG KAKWTLASIK PLSSIAGLDV TKSHRKYLCV
RNLQLVLEII ALVPTDAIAL ATGAYNALHL TRITKICRIY RIRHYLERVA NVYSDRGWVQ
HLSSTGIDTL VRNIGLCAGL CHYVACGYML LAHAQCGVSL ENCDESVETS WAVRDRLFDA
TVARKYARTL YWASRTMVLL GYDDVTPVSD AETVYAVIVT LMGALFGSSV LATFLFIFRI
RNARYAAFTT HVDNAREYMH SKNITRTIRR QVTAYFSYSW STHHSLDSEE ALHIMPKHLQ
SKVVATLKAT RIKQVCFLMK ESVEFVNLLA LALVRRVYSP ADQITEPKFN VQMFFVIRGK
VVLSSFNGSS PKECNTGDFF ADACLLFPEK YEEKAIAKTF CELYVLAKAK FDEAVTFSHR
GNEVAVRTRM IETLEKYSTQ LRKTKRLLGL RGGHESGGRN SVGGSTHSVA DEAYSGEMRR
GVSWRLPGSM FRVYWETARL IAVIYVAFEA PFFSVFIAMS DDQDMFAEQP KFGVRYGLTL
LVEVYFAVDL VLRSRYFAFL DQSVMLEVTQ PDLIFAAYRA SGFYVDLLAW LPVGLIFDSH
PISAARGRLS LIRLLRLLRV REMPGLFRSI SDYHGVSSKA HLVVSLLLGV TLMLHVVGCV
WFEMAWIERG STFEDASSEV MSELSRENCL QHATLFQNCS WVKFDCYAHI GEAFPVEEPS
SMYTSSFAYL RSVYWAVVTL TAVGYGDIVA YSTAESYFAA LWIFMGGIIN FGVVGAMSST
ITNVMATRHH HIEKMNTLNS ILERMDISEK LSGEIRRFYH HQFVEHKHAY ESQLLSHLPD
QLCYQISSLL HSEAVKNVPL FDSASTEFLH EITGKFRHHS YQHGETICLE GDICREFFVF
LHGSKVNVFF RVRKVPIRAL NGGECYGITE FLLRKAHSAT LIAASFVQAS VMTREQFDVI
QRKFASDLND IKEEAHIMWI DQHNSMRRVV HNLERLKLQP HMMQTSTLFC QHDTMAIIPG
KSGGKNEKQG LRDVDAIRGT FTSIWNAVIT CWNIYNVIFV IFRICFHAHL HFSGGLSTVV
WLADFGCDFC FVFDIYLRLY YFGGSEVGFE NLVSRQEMDS QYLHSATFRW DLVASLPLYV
PRASGSVVVS LCRLPRLVRC VDLLTYLDDV IVQIQQHFAS HNVSAYLSPA KLMIILVLVA
HCVGCIFFLI SENECEHVER CWMAEDHLLH QYHNSVPILY AKSFYWSITT LLLVGSRESI
PRDAAGTLWT AFTCLGCTFI IGHIVGEISE LILELGKEAK QYKDRIASFD SFAKEHELPE
NLRERVSFFF HLQFEHTKGL DLHSTVHDLS ANLRLKMMLE VYGHSIALLP IRSFLTALQI
NNLALRMQSE LFIPGDNILV EGTYGSRLCI MRKGLAAAFW TNSVTSVAAL MQGALFGEVA
FFLSKQRRLA TVRATTSCEV LYVTKHDWKE LWTTDGDLSD IQIQKHALHA ILDWVRGRLL
RYQRSNLRTA SRAKRITRAS MRRSHSLPLF EAKYFQGLTQ EGKTGLKMID GETWRGNIDF
AIIQRCQRPQ YATQLRLYHQ YRQWRNPDFT PGTAIAQAPS MTNIAKRLSD VRPVTPQLRA
SFQFLEPILR TSNVQRPSLM GMKFQLVNER TDILDPKSRA FIRRIKELGK VWGIGMLAVA
LYHVTITPLK LCFATDLTEL PQSTLRTWAG FEVFMDILCV MDVSYRIRYA SLPVHSMGTN
LVSSTQGGFR RVFLYNPALR ADILAMIPLE LLLFVSEVRV PLAYAPSIAE TAHCSWWTSR
WFLRMNRFLL VQRIEPLSEK LFQYLVYDRK VPVSDAALYF VRGLASYLAM GHILACIWFV
TSERAFHHYG TSWLSTSGML TYVPTVEDAG RMLTEQSTTF YLGSVSLSRK YLRSLLFSME
CISTLFYGDI LSMNPLELVA EIVITLWSIY IYGALVGAQG ELLNAQARRE AAFEQNLGEL
QHYLVQNEVP KKLKRQIKSY YARVWRRRKG ENEFAAVTSV SRLLYEDVVL ATLRGFATRV
VAFRTLDEHF LRGLLVCLKY VVCSEGEEVT MKGDVDHSMY FIANGRVLVK LDAAESIRER
GDHFGELALL YGISRLETCV ALTLTELYRL DQQPYEELLQ NFPEYRERNK LDWTSCNAPA
PDRTMLEAVV RNFQSGSTRK STTRVSRFDT PLVPALNADD VVANAERINA DVPYSHIYKF
MMDLLAHLHR VDPGSKATEG TAGFGYISRG ASTCRPRLLV SNWLVPVACT VSPTPI
//
