ID G5A2H4_PHYSP Unreviewed; 1249 AA.
AC G5A2H4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Formin-homology 2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHYSODRAFT_352574 {ECO:0000313|EMBL:EGZ09865.1};
OS Phytophthora sojae (strain P6497) (Soybean stem and root rot agent)
OS (Phytophthora megasperma f. sp. glycines).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1094619 {ECO:0000313|EMBL:EGZ09865.1, ECO:0000313|Proteomes:UP000002640};
RN [1] {ECO:0000313|EMBL:EGZ09865.1, ECO:0000313|Proteomes:UP000002640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P6497 {ECO:0000313|EMBL:EGZ09865.1,
RC ECO:0000313|Proteomes:UP000002640};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
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DR EMBL; JH159159; EGZ09865.1; -; Genomic_DNA.
DR RefSeq; XP_009534726.1; XM_009536431.1.
DR AlphaFoldDB; G5A2H4; -.
DR STRING; 1094619.G5A2H4; -.
DR EnsemblProtists; EGZ09865; EGZ09865; PHYSODRAFT_352574.
DR GeneID; 20649289; -.
DR KEGG; psoj:PHYSODRAFT_352574; -.
DR InParanoid; G5A2H4; -.
DR OMA; PRYTQRI; -.
DR Proteomes; UP000002640; Unassembled WGS sequence.
DR GO; GO:0071203; C:WASH complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00065; FYVE_like_SF; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR019309; WASHC3.
DR InterPro; IPR026870; Zinc_ribbon_dom.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF6; PROTEIN DIAPHANOUS; 1.
DR Pfam; PF10152; CCDC53; 3.
DR Pfam; PF02181; FH2; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF13240; zinc_ribbon_2; 1.
DR SMART; SM00498; FH2; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002640};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1249
FT /note="Formin-homology 2 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003472879"
FT DOMAIN 59..114
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 586..983
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 188..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1104..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 257..312
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 857..926
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 202..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1249 AA; 137571 MW; 87988C614DC4FF29 CRC64;
MSAAHWNFFL LLLPSLIPCA TNFIFSRLRH AGAVEAGGGK RNSHCLSLAP DDAFAREPEC
GVCAKSFNIL RRRHHCRSCH IAVCKECGRK AIDRKKPERS RPQWYCMGCL EDDATLEITG
SRPTVSKRRS FSSSSSSFAP ASAPQVTNLA STAKFCIECG YELPPRVKFC IECGTSVRQQ
LMSPVSVDGV GAADGERGNR GYRDSLTTNL MVIDENSGSP TEPTDGSEDD APAEQESEDD
APVKKKVDVG LETPEGDEDA AARAKEVEEL VAQLQVENEK LRNRVEKFKR KISEAERRRL
EREEEHARAV SEATAAAAAA ATAAAEAQAN NRSASEAAPQ AASAPFAAVA APTSNGTGVA
AKDHPDYLKY FKLVTMGLPA EQVKMKMQAA GVDPSILDDP DAIIGGAAPN ADTTSAPPGA
TGGTLVKDDE QYAKFFKLLK MGMPAEQIKL KMSASGLNPD LLDTPNAPMP GSGAAAAPAA
AANQVMTVKE DPAYEKFFKL VKMGMPAEQV KMKMSAAGLN TDLLDTPDAP SPNQKAAGGN
GGGGLLAGLP PPTEAVKVDP SALKASLASK LNKPIPKKPE EPQLPKKETV KPNVELRPLF
WTRVPVNVVS STVWMKLNDS HAELDVDEME WMFRKNPVEA SKKMDEKKKE AEKVPAQPKE
VLLFDPKRQQ NVSIAIARFK MSSEDIKNAI YALDGQKLGS EVLNVLISIS PTLEEIDMLK
NYDGDVKLLG NVEKFFLDLL TIPRYTQRIK CFRYKLQFEN RILETQAQLD TLVAATDQVT
ESDKFRRVLE HILAIGNYLN GSTPRGGAYG FKLDTLMKLH TLKSVDPRVT LMHFLLRQLE
EKAPDVITFA GEVPHIVEAK RLSLDQLRAD LSSYNTELAM LKGQVRASKN DHIEGDKFYE
VMTPFAKDAE EVLEELGRDF NGLETSYQEL VSSFGEDPRK VGPMEFFSIL DEFVTEFKKA
YRQNQTKEYQ TIYEEAAAAR AAAEAEKAEQ LKREAEERQR QEEERQQNSL ETKAIYAEIM
AIITAWAEKH SPGNEEAVIE QFKDVSRRFG MDEITADEFC DQVRQCVGSK CAGKIILNSA
KLLSDEAKRN ILLEALARFK EQVKKEKESK KQQRNSLVSP PSEGRERAGS SSAGRKRNKV
VVPLPIKDIE PVVGEEAQLL HKSILESVLA AFGGDPKKMK SFTSHTRKYG NEQITAHEFY
QYLTDSFEPD FVGRLVPDLA RLLQDSEKRH ALIRALCESA PGWARFAGL
//
