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Database: UniProt
Entry: G5AFA7_PHYSP
LinkDB: G5AFA7_PHYSP
Original site: G5AFA7_PHYSP 
ID   G5AFA7_PHYSP            Unreviewed;      3954 AA.
AC   G5AFA7;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   20-JUN-2018, entry version 35.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=PHYSODRAFT_532805 {ECO:0000313|EMBL:EGZ05897.1};
OS   Phytophthora sojae (strain P6497) (Soybean stem and root rot agent)
OS   (Phytophthora megasperma f. sp. glycines).
OC   Eukaryota; Stramenopiles; Oomycetes; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=1094619 {ECO:0000313|Proteomes:UP000002640};
RN   [1] {ECO:0000313|EMBL:EGZ05897.1, ECO:0000313|Proteomes:UP000002640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P6497 {ECO:0000313|EMBL:EGZ05897.1,
RC   ECO:0000313|Proteomes:UP000002640};
RX   PubMed=16946064; DOI=10.1126/science.1128796;
RA   Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H.Y., Aerts A.,
RA   Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA   Damasceno C.M.B., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA   Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J.,
RA   Huang W., Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H.,
RA   Lee M.-K., McDonald W.H., Medina M., Meijer H.J.G., Nordberg E.K.,
RA   Maclean D.J., Ospina-Giraldo M.D., Morris P.F., Phuntumart V.,
RA   Putnam N.H., Rash S., Rose J.K.C., Sakihama Y., Salamov A.A.,
RA   Savidor A., Scheuring C.F., Smith B.M., Sobral B.W.S., Terry A.,
RA   Torto-Alalibo T.A., Win J., Xu Z., Zhang H., Grigoriev I.V.,
RA   Rokhsar D.S., Boore J.L.;
RT   "Phytophthora genome sequences uncover evolutionary origins and
RT   mechanisms of pathogenesis.";
RL   Science 313:1261-1266(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; JH159165; EGZ05897.1; -; Genomic_DNA.
DR   RefSeq; XP_009538758.1; XM_009540463.1.
DR   EnsemblProtists; EGZ05897; EGZ05897; PHYSODRAFT_532805.
DR   GeneID; 20661793; -.
DR   KEGG; psoj:PHYSODRAFT_532805; -.
DR   InParanoid; G5AFA7; -.
DR   KO; K10747; -.
DR   Proteomes; UP000002640; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00204; ANK; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00248; ANK; 9.
DR   SMART; SM00015; IQ; 12.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
DR   PROSITE; PS50096; IQ; 2.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002640};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002640}.
FT   DOMAIN      637    787       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN     3507   3834       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT     3581   3613       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT     3710   3742       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT     3745   3778       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT     3779   3811       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   COILED       42     74       {ECO:0000256|SAM:Coils}.
FT   COILED      167    187       {ECO:0000256|SAM:Coils}.
FT   COILED     1654   1674       {ECO:0000256|SAM:Coils}.
FT   COILED     2019   2039       {ECO:0000256|SAM:Coils}.
FT   COILED     2101   2121       {ECO:0000256|SAM:Coils}.
FT   COILED     2165   2192       {ECO:0000256|SAM:Coils}.
FT   COILED     2268   2288       {ECO:0000256|SAM:Coils}.
FT   COILED     2294   2342       {ECO:0000256|SAM:Coils}.
FT   COILED     2377   2397       {ECO:0000256|SAM:Coils}.
FT   COILED     2871   2891       {ECO:0000256|SAM:Coils}.
FT   COILED     2901   2921       {ECO:0000256|SAM:Coils}.
FT   COILED     2929   2956       {ECO:0000256|SAM:Coils}.
FT   COILED     2978   2998       {ECO:0000256|SAM:Coils}.
FT   COILED     3187   3221       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3954 AA;  454673 MW;  37C44BD9DE979637 CRC64;
     MDRTRSFFGA GASTPPAKKR KPADDDAGDA VESPAKPVKK PKKKEKKEEK KEEKKEKIIE
     EEEEEEKEKQ VEEEPEDIEM QEAEEEEEEE VVKSKTKPGR RRLRQRVVEE EDEDSDLDLP
     MSTEKKASKE KQEEVIDMTS PTSTPEKSKK KETDKKGETP VKSKSPKKEE KEEEDDEEVE
     IKEEKAEEVK PKKEAKKETA TKNSFFTPVS GSNKSKAKMT SADDKKEKEV KTESEPKAKT
     ETTEAQDDDS DEPRETPYFA LAHLFAKIEE VTGRLVIQDL LTAFFRDVIR RSPDDLLACI
     YLCVCVDLAP PFENLKIGIG DAILMKAIGE ATGANLKFIK EMYHKEGDLG KVAQNARSKQ
     KTLSFASIKP AASKGSGLTV QHVYNQFVKI AKMTGNNSQQ QKCSIIKGLL VKCEKEKKSQ
     ASGAQSAEGA KYIIRGLQGK LRIGLAEKSI LMGLTYAFMT DKTYKDKDKQ QEALAYVKKA
     FAECPSYNAL VAAFYEVQKE VPNAPFLRVK DFAKVAEKCV LTPGTPVSPM LARPTKAYAM
     VFDRFEGKPF TCEYKYDGER AQIHILPNGE IAIFSRNFEN STERFPDVKL AISEATKKKG
     IVKSCIVDAE VVAVDRATNK RLPFQILSTR SRKNVKVEDI KVPVCIYAFD LLFLNGESFL
     ATPLAKRREK LRDMFEVKPG NFEFATSLDV EDCVDVKNNP EAIDEAVDKV RTFLEEAVRE
     NCEGLMVKTL EKEATYEPAN RSHKWLKLKK DYLDGIGDSA DLVPIGAFHG RGKRTGVYGA
     YLLACYDPDT EMYQPITKLG TGLSDEVLKQ FHDQLKEKVV DKRPSDYAIG EGIKPDVWFE
     ASCVWEILGA DLSISPKYTA AIGLVAEDKG ISLRFPRFIR IRDDKDTTQA TNSSQIADLY
     RAQGLTTVTN DGRAPAPRRT TNFDGHRRHD QQRLLVELEL DDSLYQGTLQ AGIEQHAPMY
     PVPSRRSTHA GDSRHLQHSD YIVEPRQRLS SRNPRDSTAK PLTERQMQQL NAKRLSSPYK
     LKQQVLDTRN DSPPRRYQQE GSGTRRAIRS PTMQQSPAHL VMESIRQNMH LRDQVLAHLQ
     QELMGVLPLH RASHVEKNVP QRVVKLLNRM RSLSLAVIEA VVYLSGELGD SNVVGQSVEH
     EVLEQDFFGY LLTMASDSDF LACSPQLQRF FEDFEVNLTR NPFVDGLSLD SSEVLLCSCH
     QSTDSGVLFC SASSSPSSLL RLLKQKLETF ALQTQGYLPG WQILPAERVA AALLHLMDLE
     TRFHAVRMIP RYLQSQIDSK RYLHQQRGPD CVTSSHGYGT FEDERIQRLD REVSQASLSS
     DHGPRRGSSV VEAWAGSPIP KPSAVPAALK QNTPDQQPPP VKTSSNTARS LSKKEEDTRR
     PSSAWIPVPT SPEPESTRSV TSTSSSARKA PADTDSAGDG VTITRLVLPP PVLDVSAAAK
     SSTRSNESER AASKRRSSKA TDKPDNRKTL VESGTQMSER STPSMVVTPK EVPAPEQSAR
     TRATRDESMQ DELSESVVSL ELDASVSPTD LGQWSNAELD SSRDITDEPR DVVDVVATPT
     ADDDREFREL EANAELAADL DDGYDCNFEY SSDEALSSIA MALQLLPNFT LSNTESTLDD
     DEVTKPEEAI PPNDYERVES SRAEAHEAEF TASRSTLNEV MEDVITELES VEQRVEALEP
     EDDEYAYSSS TAISNIAMAL SLLPSSWRDN ALTDSEVLPE QQSETLMDIN SSRLSTYRSI
     PTTFDETTME SLLASARSNT SASFSEKALV PLPETSRSSI STILNEEIMN SQPTSARSNI
     SATLSDKVVN LPPSSRSSAL ASTNYQADDE SELSEFNRVF ALCRDIQVAA YDMSHWVSRR
     EVEDEIQSIS QPFSSLMGYS SPTTKPVATD SSPKYLEREL KMLRRNLASW KVFCVEQKRA
     RVVVRWLVAR RKVRQFVSLH YRRQLQARID AENRLRFLAA SRIQRNWKIH RHNREVLQRK
     AVFRAIHMAF HRAIFYVSIS KRRRVRECAK EKIVRWWRRQ RLRIRRKKQK EEKRTREKER
     QSRALKDIRR FLKEILLRRK LKAAQEMAKN ILFKEQLKWT KAKRDVERSM KMNSKHRREL
     IADMNARLAD LDRRWKTSEE ERLQLLTHHE RVVQQQQQAV EVRRRKVAAL KLQMFFRVCT
     LHKKLRSVES EKKKYELQLR NELQAKEKLD VDAQKKIGKT RTQVRVLERK LGRMSQQALQ
     TDARHREVVL DHQERERTSQ ERAARQKIKA FVDARVLLRR AEHDRFQLLT LQARLQAEKT
     EIEFMSSEDQ LEQRRAALSV ASDLQQRLSE LEARSQALLA AKSQLEAEKQ QEAQRAAAAL
     EQSRIEASMQ QIAAWVSGQM QVSKLKKVHA AMRDSAAHEL EEEKRGQRRE IEAKTREVSS
     IKASSVMHQR VSQQRNHRAV EMLRIQQQQK AALEKSIAER TRAQLVQVVI AVKLLSESES
     SKGIGQGLNS VANFQKNTQH KCLRLKYLRS MSSARKIQRV LRQRLHQQHV KRAEELALAQ
     LLLAKRRQAL ARQIQAWWRQ RIQDRRREQE RAQHQLVTFE AHLELIRVRA NVRKIQSAWR
     RWVTRERARR EQQRLAVDAH LEAIRDRALV RKIQVVWRWW IQQERERRRQ QEVAFLTHLS
     AIQARANVRK IQGAWRRWKR SERERRYHQQ LAFNAHLEAI RLRTSVRKIQ GVWRRWVLSK
     QEQRERRRVQ QLVLSSAVRI QRRWRKWQQQ QRDKAERVRI LRNASAQVIQ RKWRRWKTEE
     REKTRRSILR QACARKLQKA WKIWCEWRRR RERSAIRIQK RWKQWQEEKK EAERVRSAKM
     LAATLIQRCW HRWHARRHFE QEKARKLHQR ETLRSILRIQ RAWRRWRTKL QEKAERERQE
     KEERAVALKI QQNWTKKLFQ RNQKEEERRA KKEKAAMLLQ RVWKKWHAVK CAQNELNRLR
     QEKQESLRLK QQKLERDKQT QHASSLKIQR NLGVRQHRRK MESERIQHEQ HMAALKIQTL
     WLRWHHEQKE ELEREFIRQE QYESSVKSQR HCRISHHKRK LAEERLRHKQ SLSALKIQKN
     WRRWHRVRLE QQEKNKVEDP KAQMPPMEPS SDQQQRKQRL EAIKHRSSGR CIARAVKKYL
     QSRREDSAAT KIEAVWKAKL YRTHYLQALE AQRAEEVRAY RLAVLVLATK VQVCWRRWHS
     GVRQAKRAAV KNDELRLIQE AKALERKIMV LKRTLAAKRI QRAIASRRRL QDIKFVSQKE
     IEQKTVEGEE PTVKPLNDEP ADDQPQNEEP AGDYQEPVVE VPEEDLTRAS VEKTVNTWSH
     RELPHIMTRS MNEIMFFHDV ATVLQKCVRD YQRRKQLHFY FQRPTDDSKQ DETDGDIPAG
     HFHFYFKRAS AWLEWGGSKS TSYADSGLDT NQDTTLLRLR FDSQMTRRLL QLVEPSEEYT
     LSEIQQVLQE IAADAVPILQ SPICVQDHED VRPELRFHDV EEMELPGSVK LLRQMAQQRA
     HARRQQLLEI DTSFTEPPAS PPSPVAKSEV TIFTAVENAS VEDATFLQQR GEDLAAVESK
     MQRNALHLLS FSKENYRARA EMLEFLLACD AKLDVDSVDC NGDTPLMLYA SLGHLEFMQK
     LLEHGADILK TNRKGQNVLH RACEDDQVEV CGFLQQLMMK DSIAENILPI ETVSTLAPPA
     LSLHTPDSEG RYPLHCLAEK GFVECAKQLV VPTEANYEWN RMQQAQGDSQ GRTALHLAVL
     THDTAMTSFL LTPGGGCNVD AFDDLHRSPL HYAVESPAAL PIIARLFQHG ATVNVADERG
     DTPLHWAAFS GRAAVAQNLL TLGADPTLVN SDWETPAQIA AAYGQLDCMR LLLQAQRRYG
     AAASSPPKEG ALIRPGSEKT ALQRLEEAVN HLHQRQASAH SQHAADLDAG IDTASNDAEG
     EGEATSQAEQ SHAAYWEELH QDVQLVEESG HFSSEDEDED DPLFGRDGDD DLNF
//
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