ID G5AJR8_HETGA Unreviewed; 793 AA.
AC G5AJR8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Protein sel-1 homolog 1 isoform 1 {ECO:0000313|EMBL:JAN98800.1};
DE SubName: Full=Sel-1-like protein 1 {ECO:0000313|EMBL:EHA97278.1};
GN Name=SEL1L {ECO:0000313|EMBL:JAN98800.1};
GN ORFNames=GW7_05447 {ECO:0000313|EMBL:EHA97278.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA97278.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA97278.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAN98800.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:JAN98800.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the sel-1 family.
CC {ECO:0000256|ARBA:ARBA00038101}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH165527; EHA97278.1; -; Genomic_DNA.
DR EMBL; GEBF01004832; JAN98800.1; -; Transcribed_RNA.
DR RefSeq; XP_004837157.1; XM_004837100.1.
DR AlphaFoldDB; G5AJR8; -.
DR STRING; 10181.G5AJR8; -.
DR GeneID; 101724591; -.
DR KEGG; hgl:101724591; -.
DR CTD; 6400; -.
DR eggNOG; KOG1550; Eukaryota.
DR InParanoid; G5AJR8; -.
DR OrthoDB; 1378605at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000018590; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00062; FN2; 1.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR11102:SF70; PROTEIN SEL-1 HOMOLOG 1; 1.
DR PANTHER; PTHR11102; SEL-1-LIKE PROTEIN; 1.
DR Pfam; PF00040; fn2; 1.
DR Pfam; PF08238; Sel1; 11.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM00059; FN2; 1.
DR SMART; SM00671; SEL1; 12.
DR SUPFAM; SSF81901; HCP-like; 3.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..793
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007660993"
FT TRANSMEM 742..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 121..169
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT REGION 18..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..793
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 126..152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 140..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 793 AA; 88390 MW; CC1238AC57B567E0 CRC64;
MQVRVGLTLL LCAVLLGSAS PSSDEEGNQD ESLDSKTSLP SDESVKDHTT TGRVVAGQIF
VDSEESELES PIQEEENSLK SQEGKSATEE ISFLESPNPE KDYEAPKKVR KPALTAIEGT
AHGEPCHFPF LFLDMEYVAC TSDGREDGRL WCATTYDYGT DEKWGFCETE EEAARRRQME
EAEMLYQTGM KILNGSNKKS QKREAYRYLQ KAASMNHTKA LERVSYALLF GDYMTQNIQA
AKEMFEKLTE DGSPKGQTGL GFLYASGLGV NSSQAKALVY YTFGALGGNL IAHMVLGYRY
WAGIGVLQSC ESALTHYRLV ANHVASDISL TGGSVVQRIR LPDEVENPGM NSGMLEEDLI
QYYQFLAEKG DVQAQVGLGQ LHLHGGRGVE QNHQRAFDYF NLAANAGNSH AMAFLGKMYS
EGSDIVPQSN ETALHYFKKA ADMGNPVGQS GLGMAYLYGR GVQVNYDLAL KYFQKAAEQG
WVDGQLQLGS MYYNGIGVKR DYKQALKYFN LASQGGHILA FYNLAQMHAS GTGVMRSCHT
AVELFKNVCE RGRWSERLMT AYNSYKDGGY NAAVIQYLLL AEQGYEVAQS NAAFILDQKE
ATIVDENETY PRALLHWNRA ASQGYTVARI KLGDYHFYGF GTDVDYETAF IHYRLASEQQ
HSAQAMFNLG YMHEKGLGIK QDIHLAKRFY DMAAEASPDA QVPVFLALCK LGVVYFLQYI
RETNIRDMFT QLDMDQLLGP EWDLYLMTII ALLLGTVIAY RQRQHQDLPV PRPPGPRPAP
PQQEGPPEQQ PPQ
//
