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Database: UniProt
Entry: G5AKU8_HETGA
LinkDB: G5AKU8_HETGA
Original site: G5AKU8_HETGA 
ID   G5AKU8_HETGA            Unreviewed;       741 AA.
AC   G5AKU8;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   31-JUL-2019, entry version 44.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 1b {ECO:0000313|EMBL:EHA97641.1};
GN   ORFNames=GW7_10137 {ECO:0000313|EMBL:EHA97641.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA97641.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHA97641.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; JH165689; EHA97641.1; -; Genomic_DNA.
DR   STRING; 10181.XP_004843834.1; -.
DR   MEROPS; M12.201; -.
DR   InParanoid; G5AKU8; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00117091};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Integrin {ECO:0000313|EMBL:EHA97641.1};
KW   Membrane {ECO:0000256|SAAS:SAAS01078504, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01078486,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01078482,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    673    690       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      180    374       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      383    467       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   DOMAIN      606    640       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REGION      641    663       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      704    741       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    716    741       Acidic. {ECO:0000256|SAM:MobiDB-lite}.
FT   DISULFID    439    459       {ECO:0000256|PROSITE-ProRule:PRU00068}.
FT   DISULFID    630    639       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   741 AA;  81458 MW;  76C74302D50ACB6A CRC64;
     MVLLPSIHCH LGPVHYSSYE IVIPKSLTVK GSEEPVEKTS YMLLMQGQEQ LVHLKVRRDY
     FVNDFPVYSY HSGILGQEIP SISHDCHCEG YIEGVAGSFV SVNTCSGLRG ILIKEKTSYG
     IEPTLSSKRF EHALYTMAQQ APVPCSVSPR DSQAVSASQQ QEGRKPHDLQ ALSYLWSHTK
     YVEMFVVVNS QRFQMWRSDV NETVQRVVDV IALANIFTRG INTEVVLAGM EIWTEGDLIE
     VPGDLQVTLR NFNSWRQEEL FPRERHDVAH MIVGHHPGET SGQAFLNGAC SSGFAAAVEA
     FQHEDALLSA ALMVHQLGHN LGIQHDHSAC VCKDKHFCLM HENITKESGF SNCSSDYFYH
     FLHEHKGACL FNKPRHKGRR RRDASCGNGE VEDLEECDCG SACHSDPCCE PTCKLKEHAQ
     CGNGLCCSNC KMQMRGHTCR HPVGPCDLPE YCDGVSAKCP ADMHMQDGTK CHFKYSCLNA
     KCTDPSVQCA TLFGFGSTSA PEECYNSFNS KGNIFGNCGH SGNPATYISC SGDNIKCGNL
     ICTGINSLPP IKPLYALIQS PHEDNWCWSM GTFDTASSSE EGVLMGIPCA ENKACVKSQC
     DNFTPEKGTC SAVEKCNENG VCNNLGNCHC QDGFAPPDCK TEGSGGSVDS GPPNKPSFAI
     PPDKTEEKWT SKLLLIALVV LGLLILLRVI CVCCCKRPAA AAVAAAAPPE KTAEEAQEEK
     EEEEEEEEEE EEEEEEEDDE D
//
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