ID G5ALS9_HETGA Unreviewed; 469 AA.
AC G5ALS9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Keratin, type II cytoskeletal 1b {ECO:0000313|EMBL:EHA97989.1};
DE Flags: Fragment;
GN ORFNames=GW7_03786 {ECO:0000313|EMBL:EHA97989.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA97989.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA97989.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH165888; EHA97989.1; -; Genomic_DNA.
DR AlphaFoldDB; G5ALS9; -.
DR STRING; 10181.G5ALS9; -.
DR eggNOG; ENOG502QQIF; Eukaryota.
DR InParanoid; G5ALS9; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF24; KERATIN, TYPE II CYTOSKELETAL 1B; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 157..469
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 233..260
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 368..441
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHA97989.1"
FT NON_TER 469
FT /evidence="ECO:0000313|EMBL:EHA97989.1"
SQ SEQUENCE 469 AA; 51945 MW; EF4B40AFFA0A4478 CRC64;
SRSRRAYSNR SFSGSGGRSR AAGSVSQAQG RCDSGEYGGH GRGFGSRSLF NLGGSKSISM
GLVGRSASGF HQGRGAGGGF GGGRSFGGGG FPGGRFGGAG LGGGGLGGAG FGASNFGPGG
FGPSFSGGIH EVTINQSLLE PLHLEVDPEI QRIKSQEREQ IMVLNNKFAS FIDKVRFLEQ
QNKVLQTKWE LLQQVDISTR TSNLETLFES YISGLWKNVD FLNNEQMRKS SEIRSMQDVV
EDYKNKYEEE INKRTSSENE FVVLKKDVDA AYVSKTDLES KVDTLLGEVN FLKYLFQMEL
SQMQTHISDT NVILSMDNNR TLDLDSIIEA VQAEYELIVQ RSKDEAELLY QTKYQELQIS
AGRHGNDLKN TKMEIAELNR NIQRMQAEIG NVKKQIEQMH SAISDAEERG QRALEYAKQK
LQDMDEALQQ SKENLARLLR DYQAMLGAKL SLDVEIATYR KLLECEESR
//
