ID G5AM37_HETGA Unreviewed; 738 AA.
AC G5AM37;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Zinc finger protein 238 {ECO:0000313|EMBL:EHA98097.1};
GN ORFNames=GW7_16298 {ECO:0000313|EMBL:EHA98097.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA98097.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA98097.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. ZBTB18 subfamily. {ECO:0000256|ARBA:ARBA00038422}.
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DR EMBL; JH165919; EHA98097.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AM37; -.
DR STRING; 10181.G5AM37; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; G5AM37; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR CDD; cd18324; BTB_POZ_ZBTB18_RP58; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24394:SF18; ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR24394; ZINC FINGER PROTEIN; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF13894; zf-C2H2_4; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 78..145
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 424..451
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 464..491
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 492..519
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 520..543
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 175..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 82318 MW; DC67CF71DDF112D4 CRC64;
MLWDTDQGKA LRFLRRKIRY AVCFFSTDVT DLEPGRLRGK DLIRFMCPKG YEDSMEFPDH
SRHLLQCLSE QRHQGFLCDC TVLVGDAQFR AHRAVLASCS MYFHLFYKDQ LDKRDIVHLN
SDIVTAPAFA LLLEFMYEGK LQFKDLPIED VLAAASYLHM YDIVKVCKKK LKEKATTEAD
STKKEEDASS CSDKVESLSD GSSHMAGDLP SDEDEGEDEK LNILPSKRDL AAEPGNMWMR
LPSDSAGIPQ AGGEAEPHAT AAGKTVASPC SSTESLSQRS VTSVRDSADV DCVLDLSVKS
SLSGVENLNS SYFSSQDVLR SNLVQVKVEK EASCDESDVG TNDYDMEHST VKESVSTNNR
VQYEPAHLAP LREDSVLREL DREDKASDDE MMTPESERVQ VEGGMESSLL PYVSNILSPA
GQIFMCPLCN KVFPSPHILQ IHLSTHFREQ DGIRSKPAAD VNVPTCSLCG KTFSCMYTLK
RHERTHSGEK PYTCTQCGKS FQYSHNLSRH AVVHTREKPH ACKWCERRFT QSGDLYRHIR
KFHWPNPIER TKERGGCTDL RGPELSVFLS FQDMEMILLI EDAVNQCTLK HISVLQNPQD
YSIGVSGSRP LHRKEGEMAT CRGDHAVLAP LPSQAQKAEP GGSLMSVGFS INLHKQIALI
PNKPPAWSQR LVTTLPVRAE LAASGGQHSS QQGEEGGCYP EELELLKSMV LPVAQHLLRQ
PPSPWHRDIS FLLGPAEA
//
