GenomeNet

Database: UniProt
Entry: G5AMB3_HETGA
LinkDB: G5AMB3_HETGA
Original site: G5AMB3_HETGA 
ID   G5AMB3_HETGA            Unreviewed;      4937 AA.
AC   G5AMB3;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   28-FEB-2018, entry version 37.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|EMBL:EHA98173.1};
GN   ORFNames=GW7_16715 {ECO:0000313|EMBL:EHA98173.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA98173.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHA98173.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
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DR   EMBL; JH165993; EHA98173.1; -; Genomic_DNA.
DR   InParanoid; G5AMB3; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EHA98173.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4460   4480       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4737   4759       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4818   4841       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    798       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1014   1209       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1358   1571       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1871   1929       {ECO:0000256|SAM:Coils}.
FT   COILED     2914   2934       {ECO:0000256|SAM:Coils}.
FT   COILED     3376   3396       {ECO:0000256|SAM:Coils}.
FT   COILED     3682   3702       {ECO:0000256|SAM:Coils}.
FT   COILED     3752   3772       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4937 AA;  555021 MW;  029D6F9CB9FF63F4 CRC64;
     MGDGGEGEDE VQFLRTDDEV ILQCSATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLANTVEAGV ESSQGGGHRT LLYGHAILLR HAHSGMYLSC
     LTTSRSMTDK LAFDVGLQED ATGEACWWTT HPASKQRSEG EKVRVGDDLI LVSVSSERYL
     HLSTASGELQ VDASFMQTLW NMNPICSCCE EGYVTGGHVL RLFHGHMDEC MTISPADSDD
     QRRLVYYEGG SVCTHARSLW RLEPLRISWS GSHLRWGQPL RIRHVTTGRY LALTEDQGLV
     VVDASKAHTK ATSFCFRISK EKLDVAPKRD VEGMGPPEIK YGESLCFVQH MASGLWLTYA
     APDPKALRLG VLKKKAMLHQ EGHMDDALSL TRCQQEESQA ARMIHSTAAL YNQFIKGLDS
     FSGKPRGSGP PAGSALPIEG VILSLQDLIG YFEPPSEELQ HEEKQSKLRS LRNRQSLFQE
     EGMLTLVLNC IDRLNVYTTA AHFAEFAGEE AAESWKEIVN LLYELLASLI RGNRTNCALF
     STNLDWVVSK LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
     DVLCSLCVCN GVAVRSNQDL ITENLLPGRE LLLQTNLINY VTSIRPNIFV GRAEGTTQYG
     KWYFEVMVDE VAPFLTAQAT HLRVGWALTE GYSPYPGGGE GWGGNGVGDD LYSYGFDGLH
     LWTGHVARLV TSPGQHLLAP EDVVSCCLDL SVPSISFRIN GCPVQGVFEA FNLDGLFFPV
     VSFSAGIKVR FLLGGRHGEF KFLPPPGYAP CHEAVLPRER LHLEPIKEYR REGSRGPHLV
     GPSRCLSHTD FVPCPVDTVQ IVLPPHLERI REKLAENIHE LWALTRIEQG WTYGPVRDDN
     KRLHPCLVDF HSLPEPERNY NLQMSGETLK TLLALGCHVG MADEKAEDNL KKTKLPKTYM
     MSNGYKPAPL DLSHVRLTPA QTTLVDRLAE NGHNVWARDR VGQGWSYSAV QDIPARRNPR
     LVPYRLLDEA TKRSNRDSLC QAVRTLLGYG YNIEPPDQEP SQVESQSRWD RVRIFRAEKS
     YVVQSGRWYF EFEAVTTGEM RVGWARPELR PDVELGADDL AYVFNGHRGQ RWHLGSEPFG
     RPWQPGDVVG CMIDLTENTI IFTLNGEVLM SDSGSETAFR EIEIGDGFLP VCSLGPGQVG
     HLNLGQDVSS LRFFAICGLQ EGFEPFAINM QRPVTTWFSK SLPQFEPVPL DHPHYEVSRM
     DGTVDTPPCL RLTHRTWGSQ NSLVEMLFLR LSLPVQFYQH FRCTAGATPL APPGLQPPAE
     DEARAAEPDP DYENLRRSAG GWGEAEGGKE GTAKEGPPGG TSPAGVEAQP ARAENEKDAT
     TEKNKKRGFL FKAKKAAMMT QPPATPTLPR LPRDVVPTDN RDDPEIILNT TTYYYSMRVF
     AGQEPSCVWV GWVTPDYHQH DMNFDLSKVR AVTVTMGDEQ GNVHSSLKCS NCYMVWGGDF
     VSPGQQGRIS HMDLVIGCLV DLATGLMTFT ANGKESNTFF QVEPNTKLFP AVFVLPTNQN
     VIQFELGKQK NIMPLSAAMF MSERKNPAPQ CPPRLEVQML MPVSWSRMPN HFLQVDTRRA
     GERLGWAVQC QEPLTMMALH IPEENRCMDI LELSERLDLQ RFHSHTLSLY RAVCALGNNR
     VAHALCSHVD QAQLLHALED AHLPGPLRAG YYDLLISIHL ESACRSRRSM LSEYIVPLTS
     ETRAITLFPP CHSSEDGSRH HGLPGVGVTT SLRPPHHFSP PCFVMALPLS GAAEAPARLS
     PAIPLEALRD KALRMLGEAV RDGGQQARDP VGGSVEFQFV PVLKLVSTLL VMGVFSNEDV
     KQILKMIEPE VFKEEEEEEE EEGEEEEEED QEEKEEDEEE GAQEKEDEEK EEEEAVEEEK
     EDLEEGLLQM KLPESVKLQM CHLLEYFCDQ DLQHRVESLA AFAERYVDKL QSNQRDRYGL
     LMKAFTMTAA ETARRTREFR SPPQEQINML LQFKDSADEE DCPLPEDIQQ DLQDFHQDLL
     AHCGIQLEGE EEEPEEETTL GSRLMSLLEK VRLVKKKEEK PEEELPAEEP KPQSLQELVS
     HMVVRWAQED FVQSPELVRA MFSLLHRQYD GLGELLRALP RAYTISVSSV EDTMSLLECL
     GQIRSLLIVQ MGPQEENLMI QSIGNIMNNK VFYQHPNLMR ALGMHETVME VMVNVLGGGE
     SKEIRFPKMV TSCCRFLCYF CRISRQNQRS MFDHLSYLLE NSGIGLGMQG STPLDVAAAS
     VIDNNELALA LQEQDLEKVV SYLAGCGLQS CPMLLAKGYP DIGWNPGGGE RYLDFLRFAV
     FVNGESVEEN ANVVVRLLIR KPECFGPALR GEGGSGLLAA IEEAIRISED PARDGPGVRR
     DRRREHFGEE AHEENRVHLG HAIMSFYAAL IDLLGRCAPE MHLIQAGKGE ALRIRAILRS
     LVPLDDLVGI ISLPLQIPTL GKDGALIQPK MSASFVPDHK ASMVLFLDRV YGIENQDFLL
     HVLDVGFLPD MRAAASLDTV SIPAALATLP ASTEHPRPVL PLITKCAPLF AGTEHRAIMV
     DSMLHTIYRL SRGRSLTKAQ RDVIEDCLMA LCRYIRPSML QHLLRRLVFD VPILNEFAKM
     PLKLLTNHYE RCWKYYCLPT GWANFGVTSE EELHLTRKLF WGIFDSLAHK KYDQELYRMA
     MPCLCAIAGA LPPDYVDASY SSKAEKKATV DAEGNFDPRP VETLNVIIPE KLDSFINKFA
     EYTHEKWAFD KIQNNWSYGE NIDEELKTHP MLRPYKTFSE KDKEIYRWPI KESLKAMIAW
     EWTVEKAREG EEEKTEKKKT RKISQSAQTY DPREGYNPQP PDLSGVTLSR ELQAMAEQLA
     ENYHNTWGRK KKQELEAKGG GSHPLLVPYD TLTAKEKARD REKAQELLKF LQMNGYAVTR
     HSSPGLKDME LDTSSIEKRF AFGFLQQLLR WMDISQEFIA HLEAVVSSGR VEKSPHEQEI
     KFFAKILLPL INQYFTNHCL YFLSTPAKVL GSGGHASNKE KEMITSLFCK LAALVRHRVS
     LFGTDAPAVV NCLHILARSL DARTVMKSGP EIVKAGLRSF FESASEDIEK MVENLRLGKV
     SQARPQVKGV GQNLTYTTVA LLPVLTTLFQ HIAQHQFGDD VILDDVQVSC YRTLCSIYSL
     GTTRNPYVEK LRPALGECLA RLAAAMPVAF LEPQLNEYNA CSVYTTKSPR ERAILGLPNS
     VEEMCPDIPV LEQLMADIGG LAESGARYTE MPHVIEITLP MLCSYLPRWW ERGPEAPPPA
     LPAGAPPPCT AVTSDHLNSL LGNILRIIVN NLGIDEALWM KRLAVFAQPI VSRARPELLH
     SHFIPTIGRL RKRAGKVVAE EEQLRLEAKA EAEEGELLVR DEFSVLCRDL YALYPLLIRY
     VDNNRAHWLT EPNPNAEELF RMVGEIFIYW SKSHNFKREE QNFVVQNEIN NMSFLTADNK
     SKMAKALSPV SPQSGGSDQE RTKKKRRGDR YSVQTSLIVA TLKKMLPIGL NMCAPTDQEL
     ITLAKARYAL KDTDEEVREF LQNNLNLQGK VEGSPSLRWQ MALYWGVPGR EEDADDPEKI
     VRRVQEVSAV LYHLDQTEHP YKSKKAVWHK LLSKQRRRAV VACFRMTPLY NLPTHRACNM
     FLESYKAAWL LSEDHSFEDR MIDDLSKAGE QEEEEEEVEE KKPDPLHQLV LHFSRTALTE
     KSKLDEDYLY IAYADIMAKS CHLEEGGENG EAQEEEGEVS FEEKEMEKQK LLYQQSRLHN
     RGAAEMVLQM ISACKGETGT MVSSTLKLGI SILNGGNADV QQKMLDYLKD KKEVGFFQSI
     QALMQTCSVL DLNAFERQNK AEGLGMVNED GTVINRQNGE KVMADDEFTQ DLFRFLQLLC
     EGHNNDFQNY LRTQTGNTTT INIIICTVDY LLRLQESISD FYWYYSGKDV IEEQGKRNFS
     KAMSVAKQVF NSLTEYIQGP CTGNQQSLAH SRLWDAVVGF LHVFAHMMMK LAQDSSQIEL
     LKELLDLQKD MVVMLLSLLE GNVVNGMIAR QMVDMLVESS SNVEMILKFF DMFLKLKDIV
     GSEAFQDYVT DPRGLISKKD FQKAMDSQKQ FSGPEIQFLL SCSEADENEM INCEEFANRF
     QEPARDIGFN VAVLLTNLSE HVPHDPRLRN FLELAESILE YFRPYLGRIE IMGASRRIER
     IYFEISETNR AQWEMPQVKE SKRQFIFDVV NEGGESEKME LFVSFCEDTI FEMQIAAQIS
     EPEGEPEEDE DEGAAEAGAE AVEEGAGVAE GAASTAAAGX AGGEGTGEGE GEAAEGAGDE
     EVASDEAGTG RAEGAVAVAE GSPFRPEGAG GLGDMGDTTP VEPPTPEGSP ILKRKLGVDG
     EEEALPPDPE PEPEPKPEKA DAENGEKEEV PEPPPEPPKK TAPPPPPPKK EEAGGTGLEF
     WGELEVQRVK FLNYLSRNFY TLRFLALFLA FAINFILLFY KVSDSPPGED DMESSAAGDI
     SGAGSGGGSG WGSGAGEEAE GDEDENMVYY FLEESTGYME PALRCLSLLH TLVAFLCIIG
     YNCLKVPLVI FKREKELARK LEFDGLYITE QPEDDDVKGQ WDRLVLNTPS FPRNYWDKFV
     KRKVLDKHGD IFGRERIAEL LGMDLATLEI TAHNERKPNP PPGLLTWLMS IDVKYQIWKF
     GVIFTDNSFL YLGWYMVMSL LGHYNNFFFA AHLLDIAMGV KTLRTILSSV THNGKQLVMT
     VGLLAVVVYL YTVVAFNFFR KFYNKSEDED EPDMKCDDMM TCYLFHMYVG VRAGGGIGDE
     IEDPAGDEYE LYRVVFDITF FFFVIVILLA IIQGLIIDAF GELRDQQEQV KEDMETKCFI
     CGIGSDYFDT TPHGFETHTL EEHNLANYMF FLMYLINKDE TEHTGQESYV WKMYQERCWD
     FFPAGDCFRK QYEDQLS
//
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