ID G5AMC5_HETGA Unreviewed; 1780 AA.
AC G5AMC5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Signal-induced proliferation-associated 1-like protein 3 {ECO:0000313|EMBL:EHA98185.1};
GN ORFNames=GW7_16727 {ECO:0000313|EMBL:EHA98185.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA98185.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA98185.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH165993; EHA98185.1; -; Genomic_DNA.
DR STRING; 10181.G5AMC5; -.
DR eggNOG; KOG3686; Eukaryota.
DR InParanoid; G5AMC5; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR021818; SIPA1L_C.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF15; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 3; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF11881; SPAR_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 597..815
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 953..1017
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 45..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1225..1611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1684..1711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1724..1772
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 45..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1253..1277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1369..1385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1417..1440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1520..1539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1562..1606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1780 AA; 195135 MW; 8AB598FD2BCCAC8B CRC64;
MTTYRPLPSD GVDLAASCGA RGTDILPGPH TGDYASMGFW AQNGSMSQPL GESPATATTR
PSPTTPAMPK MGVRARVADW PPKREALREQ NNPSPSQDTD GVKGTKVAHS MRSIQNGQPP
DSTPASSGSK AFHRISRRRS KDVEFQDGWP RSPGRAFLPL RHRSNSEITL SECDVEDSGE
ARGSRHTGSA LPLFREYGST SSIDVQGVPE QSFFDILNEF RSEQPEACGA QSLGELLQAD
PGHGPKGDPR NGQPSKDSLL PLQPLKEKEK ARKKPIRGLG SGDTVDSSIF RKLRSSKPEG
EASRTLAEAE EGRSPPEASR PWVCQKSFAH FDVQSMLFDL NEAAANRVSV AQRRNTTTGA
SAASAASAMA SLTASRAHSL GGLDPAFTST EDLNCKENLE QDLGDDNSND LLLSCPHFRN
EIGGECERNV SFSRASAGSP GEGHPAEPAL SAYRTNASIS VLEVPKEQQR TQNRPQEYSI
EHVDLGARYY QDYFVGKEHA NYFGVDEKLG PVAVSIKREK LEDHKDHGPQ YQYRIIFRTR
ELITLRGSIL EDATPTATKH GTGRGLPLKD ALEYVIPELN IHCLRLALNT PKVTEQLLKL
DEQGLCRKHK VGILYCKAGQ SSEEEMYNNE EAGPAFEEFL ELLGEKVCLK GFTKYAAQLD
VKILLTDTGR SLYSHPRDYE IMFHISTLLP YTPNNRQQLL RKRHIGNDIV TIIFQEPGAL
PFTPKNIRSH FQHVFIIVRV HNPCTENVCY SMAVTRSKDA PPFGPPIPSG TTFRKPDVFR
DFLLAKVINA ENAAHKSDKF HTMATRTRQE YLKDLAENCV SNTPIDSTGK FNLISLTSKK
KEKTKARAGA EQHSAGAIAW RVAVQDYAQG VEIDCILGIS NEFVVLLDLR TKEVVFNCYC
GDVIGWTPDS STLKIFYGRG DHIFVQATEG SVEDIREIVQ RLKVMTNGWE TVDMTLRRNG
LGQLGFHVKY DGTVAEVEDY GFAWQAGLRQ GSRLVEICKV AVVTLTHDQM IDLLRTSVTV
KVVIIPPFED GTPRRGWPET YEMNTSEPKM EQENITPGSR PPYRSNAPWH NAPWQWSGPA
SHNSLPASKW VTPAAPGHAQ SLSRPLKQNP MVPFRESQPL HSKRPVSFPE TPYTASPAGA
DTVPPYRQPS GSFSTPGSAT FTRYKPSPER YVAGPHPLLS FDPHFSHDGM SSGDSSSGGL
TSQESTMERQ KPEPLWHVPA QARLSAMAGS SGSKHGIPRQ DAAGKDSPNR HSKGEPQYSS
HSSSNTLSSN ASSSHSDDRW FDPLDPLEPE QDPLSKGGSS DSGIDTTLYT SSPSCMSLAK
TPRPAKSHKP PGSMGLCGGG REAAGRLHHT DRRREVSPAP ALLGQSKGYQ PKLYSSGSST
PTGLAGGSRD LPRQPSDMGS RAGYPAQVYK AASAETPRPS QLAQPSPFQL STSVPKSFFS
KQPVRSKHPA GWKRTDEPPP RPLPFTDPKK QVDASTKNVF GQPRLRASLR DLRSPRKNYK
STIEDDLKKL IIMDNLGPEQ ERDTGQSPQK SLQRTLSDES LCSGRREPSF ANPASLEPGL
PSDVLFTSTC TFPSSTLPAR RQHQHSLAPS SSGPSTSPST IPATGNGFPE KKSAISASEL
SLADGRDRAL RRLDPGMMPL PDTAAGLEWS SLVNAAKAYE VQRAVSLFSL NDPALSPDIP
PAHSPVHSHL SLERGPPTPR TTPTMSEEPP LDLTGKVYQL EVMLKQLHTD LQKEKQDKVV
LQSEVASLRQ NNQRLQEESQ AASEQLRKFA ELFSREKKEL
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