ID G5AMP0_HETGA Unreviewed; 281 AA.
AC G5AMP0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Interleukin-3 receptor subunit alpha {ECO:0000313|EMBL:EHA98300.1};
DE Flags: Fragment;
GN ORFNames=GW7_12494 {ECO:0000313|EMBL:EHA98300.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA98300.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA98300.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; JH166018; EHA98300.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AMP0; -.
DR STRING; 10181.G5AMP0; -.
DR InParanoid; G5AMP0; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.3850; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040907; IL3Ra_N.
DR InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR Pfam; PF18611; IL3Ra_N; 1.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
PE 4: Predicted;
KW Receptor {ECO:0000313|EMBL:EHA98300.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 2..71
FT /note="IL-3 receptor alpha chain N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18611"
FT DOMAIN 83..175
FT /note="Type I cytokine receptor cytokine-binding"
FT /evidence="ECO:0000259|Pfam:PF09240"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHA98300.1"
FT NON_TER 281
FT /evidence="ECO:0000313|EMBL:EHA98300.1"
SQ SEQUENCE 281 AA; 31606 MW; E02DE00F1D54E18D CRC64;
PIGNLRVEPG SRRLTWDLLG NASGIECFKD GSTCLMAYDK YCHYSTMSLC TVTNYTVKVT
QPAFSAWILF PESGSNAEAA ARDLKCKIFD GGPMVCSWAV GTGALGDVQY QLSWRNLESE
EEGVCLRYNT DAQGRNIRCQ FDQVRALPEF MMITVNGRSN GFRVPCTDLS IELAAIETLL
PPNISTECNR THVHLSWLPP RSHFRNNLKY ELQTEQVRGP DTNEFLLPNP GRCTVRIRAR
YRSNRWTAWS PPQAFGCDRE ESSQQQRLWP ASVLAALGTL L
//
