ID G5ANA5_HETGA Unreviewed; 260 AA.
AC G5ANA5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=CD40 ligand {ECO:0000256|ARBA:ARBA00014276, ECO:0000256|PIRNR:PIRNR016527};
DE Short=CD40-L {ECO:0000256|PIRNR:PIRNR016527};
DE AltName: Full=Tumor necrosis factor ligand superfamily member 5 {ECO:0000256|ARBA:ARBA00033257, ECO:0000256|PIRNR:PIRNR016527};
GN ORFNames=GW7_07234 {ECO:0000313|EMBL:EHA98515.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA98515.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA98515.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates
CC T-cell proliferation and cytokine production. Involved in
CC immunoglobulin class switching. {ECO:0000256|PIRNR:PIRNR016527}.
CC -!- FUNCTION: [CD40 ligand, soluble form]: Acts as a ligand for integrins,
CC specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40
CC receptor are required for activation of CD40-CD40LG signaling, which
CC have cell-type dependent effects, such as B-cell activation, NF-kappa-B
CC signaling and anti-apoptotic signaling.
CC {ECO:0000256|PIRNR:PIRNR016527}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|PIRNR:PIRNR016527}.
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670, ECO:0000256|PIRNR:PIRNR016527}.
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DR EMBL; JH166132; EHA98515.1; -; Genomic_DNA.
DR RefSeq; XP_004862388.1; XM_004862331.1.
DR AlphaFoldDB; G5ANA5; -.
DR STRING; 10181.G5ANA5; -.
DR Ensembl; ENSHGLT00000065577; ENSHGLP00000046511; ENSHGLG00000046347.
DR Ensembl; ENSHGLT00100054065; ENSHGLP00100060241; ENSHGLG00100051381.
DR GeneID; 101700616; -.
DR KEGG; hgl:101700616; -.
DR CTD; 959; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; G5ANA5; -.
DR OMA; VSFCTKA; -.
DR OrthoDB; 4323672at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005174; F:CD40 receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Ensembl.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
DR GO; GO:0042100; P:B cell proliferation; IEA:UniProtKB-UniRule.
DR GO; GO:0023035; P:CD40 signaling pathway; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0045190; P:isotype switching; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0030168; P:platelet activation; IEA:UniProtKB-UniRule.
DR GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0002637; P:regulation of immunoglobulin production; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR003263; CD40L.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471:SF5; CD40 LIGAND; 1.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR Pfam; PF00229; TNF; 1.
DR PIRSF; PIRSF016527; TNF_5; 1.
DR PRINTS; PR01702; CD40LIGAND.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|PIRNR:PIRNR016527};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR016527-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 122..260
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT DISULFID 177..217
FT /evidence="ECO:0000256|PIRSR:PIRSR016527-2"
SQ SEQUENCE 260 AA; 29126 MW; 7C548CECC5D778C6 CRC64;
MIETYSQPSP RSVATGQPIS MKIFMYLLTV FLITQMIGSA FFAVYLHRRL DKIEDERNLH
DDFVFMKTIQ RCNKGEESLS LLNCEKIRSQ FEGFVKDIML NKEEKKEISY ERQKGDQDPQ
IAAHVISQAS GKTASVLQWA EKGYYTMSSS LVTLENGKQL TIKRQGLYYI YTQVTFCSNR
EPPSQAPFIA SLCLKSTSGS ERILLRAANV HSSSKPCGQQ SIHLGGVFEL QPGASVFVNV
TDPSQVSHGT GFTSFGLLKL
//
