ID G5ANT3_HETGA Unreviewed; 859 AA.
AC G5ANT3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Rabenosyn-5 {ECO:0000313|EMBL:EHA98693.1};
GN ORFNames=GW7_05995 {ECO:0000313|EMBL:EHA98693.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA98693.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA98693.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH166231; EHA98693.1; -; Genomic_DNA.
DR AlphaFoldDB; G5ANT3; -.
DR STRING; 10181.G5ANT3; -.
DR eggNOG; KOG1842; Eukaryota.
DR InParanoid; G5ANT3; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15716; FYVE_RBNS5; 1.
DR Gene3D; 4.10.860.20; Rabenosyn, Rab binding domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR021565; Rbsn_Rab-bd.
DR InterPro; IPR036531; Rbsn_Rab-bd_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13510; FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED; 1.
DR PANTHER; PTHR13510:SF44; RABENOSYN-5; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF16601; NPF; 1.
DR Pfam; PF11464; Rbsn; 2.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF140125; Rabenosyn-5 Rab-binding domain-like; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 14..42
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 157..260
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 59..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 567..617
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 209..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 859 AA; 97211 MW; 1A642136F3D18768 CRC64;
MASLDDPGDV REGFLCPLCL KDLQSFYQLQ SHYEEEHSGE DRDVKGQIKS LFQKAKKAKN
KLLRREGDEQ AEPGAPGYES FSNGGVDPYM WEPQELGTMR SHLSEFKKHR AARIDHYVVE
VNKLIIRLEK LTAFDRTNTE SAKIRAIEKS VVPWVNDQDV PFCPDCGSKF SIRNRRHHCR
LCGSIMCKKC MELISLLLAN KLTSASRDAL STHTSPNQSP GSVHGSRRGS IGSVSSMSSV
LDEKENERIR CCRHCKDTLL RREQQMDERE HTPAITRLYE SHPRTQHAAR AEESWVPSVF
ADKLTSASRD ALSTHTSPNQ SPGSVHGSRR GSIGSVSSMS SVLDEKENER IRCCRHCKDT
LLRREQQMDE REHTPAITRL YEKLRLCMAK VDQKAPEYTR MAASLNAGET TYSLEQASDL
RLEVQKMYEL IDALSKKILT LGLNQDPPPH PTTLRLQRMI RYSATLFVQE KLLGLMSLPT
KEQFEELKKK RKQDMERKRM LERQAAPESQ CRLEDKQRGP AANGEVAPTR KAEGWLPLPE
TQGQREDPDP LLQQIHNIES FIKQAQAASR TDEVRTLGEN LRQLQDEYDR QQTAKAIELS
RRQAEEEALQ CEQLQRLRER EWERERKQAA SLHSRTQALD SREAAPFLLE PSRGPRPHPA
FALELGSSSG SGMAPETPSP CAVWALSQES LHQSTEPQQN DCALNSFSRD FFSSPAVVQA
KLPREYNPFE EEEEEEEEAV AAGNPFTSPD SPAPNPFDSP APNPFEDGND VPNRSPASPP
VPSNPFEEPT GTNPFEVDSD SCPEAEEPIE EDLLLQQINN IKAYIFDAKQ YGRLDEVEVL
TENLRELRCT LAKQKGPPE
//
