ID G5APX8_HETGA Unreviewed; 466 AA.
AC G5APX8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Kremen protein {ECO:0000256|PIRNR:PIRNR036961};
DE AltName: Full=Kringle-containing protein marking the eye and the nose {ECO:0000256|PIRNR:PIRNR036961};
GN ORFNames=GW7_05321 {ECO:0000313|EMBL:EHA99088.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA99088.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA99088.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to
CC inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt
CC receptors LRP5 and LRP6. {ECO:0000256|PIRNR:PIRNR036961}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR036961};
CC Single-pass type I membrane protein {ECO:0000256|PIRNR:PIRNR036961}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR EMBL; JH166403; EHA99088.1; -; Genomic_DNA.
DR AlphaFoldDB; G5APX8; -.
DR STRING; 10181.G5APX8; -.
DR eggNOG; KOG4157; Eukaryota.
DR InParanoid; G5APX8; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00108; KR; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR017076; Kremen.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR24269; KREMEN PROTEIN; 1.
DR PANTHER; PTHR24269:SF13; KREMEN PROTEIN 1; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00051; Kringle; 1.
DR Pfam; PF01822; WSC; 1.
DR PIRSF; PIRSF036961; Kremen; 1.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00130; KR; 1.
DR SMART; SM00321; WSC; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS51212; WSC; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR036961};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR036961-50};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Membrane {ECO:0000256|PIRNR:PIRNR036961};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR036961};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR036961};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|PIRNR:PIRNR036961}.
FT TRANSMEM 347..369
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR036961"
FT DOMAIN 4..87
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 89..183
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 187..294
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 418..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 5..87
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 28..68
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 57..82
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 95..159
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 120..140
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 124..142
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 163..171
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 187..213
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
SQ SEQUENCE 466 AA; 51826 MW; 59949FA8659DDA92 CRC64;
MTAECFTANG ADYRGTQNWT ALQGGKPCLF WNETFQHPYN TLKYPNGEGG LGEHNYCRNP
DGDVSPWCYV AEHEDGVYWK YCEIPACQMP GNLGCYKDHG NPPPLTGTSK TSNKLTIQTC
ISFCRSQRFK FAGMESGYAC FCGNNPDYWK YGEAASTECN SVCFGDHTQP CGGDGRIILF
DTLVGACGGN YSAMTSVVYS PDFPDTYATG RVCYWTIRVP GASHIHFNFT LFDIRDSADM
VELLDGYTHR VLVRFNGRNR PSLSFNVSLD FVILYFFSDR INQAQGFAVL YQAIKEEVLQ
ERPTVNQTLA EVITEQANLS VSAAHSSKVL YVITTSPSHP PQSVPGWTVY GLATLLILTV
TAIVAKILLH ITFKAHRVPA SGDLRDCRQP GPSGEIWSIF YKPSTSISIF KKKLKGQSQQ
DDRNPLTEKG HHAAGQQNPD SSCFISYTWE RDSKPSTWPS LRLSLV
//
