ID G5AQ18_HETGA Unreviewed; 97 AA.
AC G5AQ18;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Protein S100-A10 {ECO:0000256|ARBA:ARBA00018065};
DE AltName: Full=Calpactin I light chain {ECO:0000256|ARBA:ARBA00033060};
DE AltName: Full=Calpactin-1 light chain {ECO:0000256|ARBA:ARBA00033448};
DE AltName: Full=S100 calcium-binding protein A10 {ECO:0000256|ARBA:ARBA00032653};
GN ORFNames=GW7_07108 {ECO:0000313|EMBL:EHA99128.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA99128.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA99128.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: Because S100A10 induces the dimerization of ANXA2/p36, it may
CC function as a regulator of protein phosphorylation in that the ANXA2
CC monomer is the preferred target (in vitro) of tyrosine-specific kinase.
CC {ECO:0000256|ARBA:ARBA00003539}.
CC -!- SIMILARITY: Belongs to the S-100 family.
CC {ECO:0000256|ARBA:ARBA00007323}.
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DR EMBL; JH166411; EHA99128.1; -; Genomic_DNA.
DR RefSeq; XP_004855308.1; XM_004855251.1.
DR AlphaFoldDB; G5AQ18; -.
DR STRING; 10181.G5AQ18; -.
DR Ensembl; ENSHGLT00000052577; ENSHGLP00000056138; ENSHGLG00000037189.
DR Ensembl; ENSHGLT00100084061; ENSHGLP00100060266; ENSHGLG00100048033.
DR GeneID; 101722111; -.
DR KEGG; hgl:101722111; -.
DR eggNOG; ENOG502S6TB; Eukaryota.
DR InParanoid; G5AQ18; -.
DR OMA; CRDGKMG; -.
DR OrthoDB; 619060at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR PANTHER; PTHR11639:SF74; PROTEIN S100-A10; 1.
DR PANTHER; PTHR11639; S100 CALCIUM-BINDING PROTEIN; 1.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..44
FT /note="S100/CaBP-9k-type calcium binding subdomain"
FT /evidence="ECO:0000259|SMART:SM01394"
SQ SEQUENCE 97 AA; 11255 MW; 0C5268EBEB317818 CRC64;
MPYQMEHAME TMMFTFHKFA GDKGYLKKED LRVLMEGEFP GFLENQKDPL AVDKIMKDLD
QCRDGKMGFQ SFFSLIAGLT TACNDYFVVH MKQKGKK
//
