ID G5ARQ9_HETGA Unreviewed; 4589 AA.
AC G5ARQ9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Protocadherin Fat 1 {ECO:0000313|EMBL:EHA99719.1};
GN ORFNames=GW7_01942 {ECO:0000313|EMBL:EHA99719.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA99719.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA99719.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; JH166623; EHA99719.1; -; Genomic_DNA.
DR STRING; 10181.G5ARQ9; -.
DR eggNOG; KOG1219; Eukaryota.
DR InParanoid; G5ARQ9; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 33.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 33.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF448; FAT ATYPICAL CADHERIN 2; 1.
DR Pfam; PF00028; Cadherin; 28.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 14.
DR PROSITE; PS50268; CADHERIN_2; 33.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..4589
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003473532"
FT TRANSMEM 4183..4203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..150
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 151..258
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 369..464
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 465..570
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 578..672
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 719..823
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 824..928
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 929..1035
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1044..1140
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1141..1246
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1247..1356
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1360..1457
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1458..1563
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1564..1668
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1669..1766
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1767..1880
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1896..1980
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1981..2082
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2083..2183
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2184..2284
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2285..2391
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2392..2493
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2494..2597
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2598..2704
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2705..2810
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2811..2919
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2920..3024
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3025..3126
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3127..3231
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3232..3336
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3337..3441
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3442..3546
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3562..3648
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3791..3828
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3830..4010
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4014..4051
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4053..4089
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4090..4126
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4128..4164
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4256..4291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4304..4328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4344..4377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4414..4448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4498..4520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4566..4589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4256..4274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4357..4377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4433..4448
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3800..3817
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4041..4050
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4079..4088
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4116..4125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4154..4163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4589 AA; 507794 MW; A485EAB9B2F2362B CRC64;
MGRHLALLLL LLLLLQHFGD SDGSQRLEQT PSIQFTHFQY NVTVHENSAA KTYVGHPVKM
GIYITNPLWE LRYKIVSGDN ENLFKAEEYI LGDFCFLRIR TKGGNTAILN REVKDQYTLI
VKAVEKNTNA EARTRVRVQV LDINDLRPLF SPTSYSVSLP ENTPIRTSIA RVSATDADIG
TNGEFYYSFK DRTDMFAIHP TSGAVVLTGR LDYMETQLYE LEILAVDRGM KLYGSSGISS
LAKLTVHVEQ ANECAPVITA VTLSPSELDR DPTYAIVTMD DCDQGASGEI ASLSIVAGDL
LQQFRTVRSF PGSKEYKVKA ISSIDWDSHP FGYNLTLQAK DKGTPPQFSS VKVIHLTSPQ
FRAGPVRFEK DVYRAEISEF SPPGTPVVMV KAIPSYSHLR YVFKSTPGKA KFSLNHNTGL
ISILEPIRRQ QASHFEFEVT TSDQKASTKV LVKVLSANSN PPEFTQTAYK ASFDENASIG
TTVLRVSAVD PDDGENGYVT YSIANINPVP FVIDHFTGAV STSENLDYEL MPRVYTLRIR
ASDWGLPYRR EVEVLATVTL NNLNDNTPLF EKINCEGTVP RDLSVGEQIT TVSAIDADEL
QLVRYQIETG NELDLFGLNP NSGVLSLKQS LMDGLGAKVS FHSLRITATD GENFATPLYI
NITVAASRKP VNLQCEETGV AKMLAEKLLQ ANKLHSQGEV EDIFFDSHSV NTHAPQFRNT
LPTGIEVKEN RPVGSNIIFM NSTDLDSGFN GKLIYSISGG NEDSCFIIDM DTGMLKILSP
LDRETTDKYT LNITVYDLGI PQKAAWRLLD IIILDANDNP PEFLQESYFV EVNEDKEINS
EIIQVEATDK DLGSNGHVTY SILTDTDKFL IDSTTGVVKI VHPLDREVQH VHYLKIEARD
QAKGEPQLFS TVLLKVSLED VNDNPPKFIP PNYRVKVRED LPEGTIIVWL EAHDPDLGQS
SQVRYSLLDH GEGIFDVDKL SGAVRIIQQL DFERKQVYNL TVRAKDKGKP VSLSSTCYVE
VEVIDVNENL HPPVFSSFVE KGVVKEDVPI GSSIMTVSAH DEDTGRDGEI QYSIRDGSGV
GVFKIDEETG VLETSDLLDR ESMSHYWLTV YAADRAVVPL SSFIEIYIEI EDVNDNAPQT
SEPVYYPEIM ENSPKDISVV QIEAFDPDSS SNDKLMYKIT SGNPQGFFSI HPKTGLITTT
SRRLDREQQD EHILEVTVTD NGTPPKSTIA RVIVKILDEN DNKPQFLQKF YKIRLPEREK
PERERNAKRE PLYRLIATDK DEGPNAEISY SIEDGNEHGK FFIEPKTGVV SSKKFSAAGE
YDILSIKAVD NGRPQKSSTT RLHIEWISKP KPSPEPISFE ESFFTFTVME SDPVAHMIGV
ISVEPPGTPL WFDIIGGNFD SHFDIDKGTG TIVIAKPLDA EQKSNYNLTV EATDGTTAIH
SQVLIKVIDT NDHRPQFSTS KYEVVIPEDT VPETEILQIS AMDKDEKNKL IYTLQSSIDP
LSLKKFRLDP ASGSLSTSEK LDHEAVHQHV LTVMVRDQDV PVKRNFARII VNVSDTNDHA
PWFTSSSYEG RVYESAAAGS VVLQVTALDK DKGKNAEVLY SIESGNIGNS FTIDPILGSI
KTAKELDRSN QEEYDLMVKA TDKGNPPMSE MTSVHIFVTV ADNASPKFTS KEYSIEISET
ISIGSFVGIV TAYSQSSVIY EIKDGNIGDV FDINPHSGSI ITQKALDFET LPIYTLTIQG
TNMAGLSTNT TVLVHLQDEN DNIPVFIQAE YSGLISESAS INSVVLTDRN VPLVIRATDA
DKESNALLVY HIVEPSVHKY FAIDSTTGAI HTVLSLDYEE TSVFHFTVQV HDMGTPRLFA
EYAANVTIHV IDINDCPPVF SKSLYEALLL LPTYRGVKII TVNATDADSS AFSQLIYSIT
EGNIGEKFFM DYKTGTITIQ NTTQLRSRYE LTIRASDGRF ASFTSVKINV KESKESQLKF
TQDFYSAVVK ENSTEAKTLA VITAIGNPIN EPLFYHILNP DRRFKISCTS GVLSTTGIPF
DREQQEAFDV VVEVTEEHKP SAVAHVVVKV TVEDQNDNAP VFINLPYYAV VKVDTEVGHV
IRYVTAVDRD SGRNGEVHYY LKEHHDHFQI GPSGEISLKK QFELDTLNKE YLVTVVAKDG
GNPAFSAEVI VPITVMNKAM PVFEKPFYSA EIPENIQMHS PVVHVQANSP EGLKVFYSIT
DGDPFSQFTI NFNTGVINVI APLDFESHPA YKLSIRATDS LTGAHAEVFV DIIVEDINDN
PPVFVQQSYS ATLSEASVIG TSVVKVRATD SDSEPNRGIS YQMFGNHSKS QDHFHIDGST
GLISLLRTLD YEQFQQHKIF VRAIDGGMPP LSSDVIVTVD VTDLNDNPPL FDQQIYEAKI
SEHATHGHFV MCVKAYDADS SDIDRLEYSI LSGNDHKNFV INSETGIITL SNLRRHNLKP
FYSLNISVSD GVFRSSAQVH VTVIGGNLHS PVFPQNEYEV ELAENAPIHT LVIEVKATDK
DSGIYGHITY SIVNDFARDR FYTNEIGQVF TLEKLDRETL AEKVISVRLM AKDTGGKVAF
CTINVILTDD NDNAPQFRAT KYEVNIGSSA AKGTSVMKVF ASDTDEGSNA DVTYAIEADS
DSVKENLEIN KLSGIITTKE SLIGLENEFF TFFVRAIDNG SPPKESVVPV YVKILPPERQ
LPKFSEPFYT YTVSEDTPIG TEIDLIRAEH SGTVLYSMIK GNTPESNRDE FFVIDRQSGR
VKLEKSLDHE TTKWYQFSIL ARCTHDEYEV VASVDVSIQV KDANDNTPVF ESNPYEAFIV
ENLPGGSRVI QVRASDLDSG MNGHVMYSLD QSQSVDIIES FAINMETGWI TTLKELDHEE
RDIYQIKVVA SDHGEKVQLS STAIVAVTVA DVNDSPPRFT AEIYKGTVSE DDPPGGVIAI
LSTTDADSEE INKQVTYFIT GGDTLGQFAV ENIQNEWKVY VKKPLDREKK DSYLLTITAT
DGTFSSKAIV EVKVLDANDN SPVCEKTLYS DTIPEDALPG KLIVQVSATD ADIRSNAEIT
YTLFGSGAEK FKVNPDTGEL KTLAPLDREE QAVYNLLVRA TDGGGRFCQA NIVLPLEDVN
DNAPQFTADP YTVTVFENTE PGTLLTRVQA TDADTGLNRK ISYSLIDSAN GQFSINEISG
IIQLEKPLDR ELQAVYTLVL KAVDQGLPRK LSATGTVVVS VLDINDNPPV FEYREYGATV
SEDILIGTEV LQVYAASRDI EANAEITYSI INGNEHGKFS IDSKTGAIFI IENLDYESAH
EYYLTVEATD GGTPSLSDVA TANINVTDIN DNTPSFSQDT YMAVISEDAV LEQSVITVLA
DDADGPSNSL IHYSIIEGNQ GSPFTIDPVK GEVKVTKLLD RETISGYTLT IQASDNGSPP
RVNTTTVNID VSDVNDNAPV FSKGNYSVII QENKPVGFSV LQLVVTDKDS SHNGPPFFFS
IVSGNDDRAF EVNQQGVLLT SATIQRKVKE HYLLHVKVAD NGKPQLSSLT HIDIRVIEES
IHPPAILPLE IFITAFGEEY SGGVIGKIHA TDQDVYDTLT YSLDPDMDSL FSVSSTGGKL
IAHKRLDIGQ YLLNVSVTDG KFTTVADITV HIRQITQEML NHTIAIRFAN LTPEEFVGDY
WRNFQRALRN ILGVRRNDIQ IVSLEPSEPH PHLDVLLFVE KSDSTQVSTK QLLHKINSSV
TDIEEIIGVR ILAVFQKLCA GLDCPWKFCD EKVSVDENFM STHSTARLSF VTPRHHRTSV
CLCKEGKCPP IQHGCEDSPC PAGTECVADP REEKYTCVCP SGKFSQCPGS SSVTFTGNSF
VKYRLMENEN KLEMKLTVRL RTYSTHAIVM YARGTDYSIL EIHNGRLQYK FDCGSGPGIV
SVQSIQVSDG QWHVVSLEVN GNYARLVLDQ VHTASGTAPG TLKTLNLDNY VFFGGHIRQQ
GTRHGRSPQV GNGFRGCMDS IYLNGQELPL NSKPRSYAHI EESVDISPGC LLTATEDCSS
NPCENGGICH PSPTGGYYCK CSALYIGTYC EVSVNPCSSN PCLYGGTCVV DNGDFVCQCR
GLYTGQRCQL SPYCKDEPCK NGGTCFDSLD GAVCQCDSGF RGERCQSDVD ECAGNPCHNG
APCENTHGSY HCNCSHEYRG KHCEEAAPNQ YVSTPWNIGL AEGIGIIVFI AGIFLLVVVF
VLCRKMISRK KKHQAEPEDK HLGPTTAFLQ RPYFDSKLNK NIYSDIPPQV PVRPISYTPS
IPSDSRNNLD RNSFEGSAIP EHPEFSTFNP ESMHGHRKAV AVCSVAPNLP PPPPSNSPSD
SDSIQKPSWD FDYDTKVVDL DPCLSKKPLE EKPSQPYSAR ESLSEVQSLS SFQSESCDDN
GYHWDTSDWM PSVPLPDIQE FPNYEVIDEH TPLYSADPNA IDTDYYPGGY DIESDFPPPP
EDFPAPDELP PLPPEFSDQF ESIHSPRNMP AAGSLGSSSR NRQRFNLNQY LPNFYSVDMS
EPQKKGTGEN NTCREPYAPY PPGYQRNFDA STVENMPMSV YASTASCSDV SACCEVESEV
MMSDYESGDD GHFEEVTIPP LDSQQHTEV
//
