ID G5AS65_HETGA Unreviewed; 623 AA.
AC G5AS65;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Autophagy-related protein 16-2 {ECO:0000313|EMBL:EHA99916.1};
GN ORFNames=GW7_02113 {ECO:0000313|EMBL:EHA99916.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA99916.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA99916.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the WD repeat ATG16 family.
CC {ECO:0000256|ARBA:ARBA00009271}.
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DR EMBL; JH166727; EHA99916.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AS65; -.
DR STRING; 10181.G5AS65; -.
DR Ensembl; ENSHGLT00100019511; ENSHGLP00100019311; ENSHGLG00100014239.
DR eggNOG; KOG0288; Eukaryota.
DR InParanoid; G5AS65; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR CDD; cd22887; Atg16_CCD; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR045160; ATG16.
DR InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19878; AUTOPHAGY PROTEIN 16-LIKE; 1.
DR PANTHER; PTHR19878:SF7; PROTEIN ATG16L2; 1.
DR Pfam; PF08614; ATG16; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 20..211
FT /note="Autophagy-related protein 16"
FT /evidence="ECO:0000259|Pfam:PF08614"
FT REPEAT 336..377
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 380..421
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 422..463
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 560..589
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 64..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 129..220
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 623 AA; 68763 MW; 85B643ED16B67A18 CRC64;
MAGSGGLSVP DAPAALWKRH IMRELRQRDR TQKALFLELV PAYNHLLEKA ELLATFSEKL
HLEPSNVTPA SDQGSWEEES RPESDQVPSL ATLKVKWQEE EEGLRLVCGE MAYQVVEKSA
ALGTQQLQLE ERQGRLAVLE AQVAHLQEAR AKQTQLVEEQ RAQNVVQRTA YEVLRVRTGN
QEAELRRLQE EASCLLERLV QLKARAADEL NLRLERLERA SQARVSQELK KAAKRTVSIS
EIPDSLGKGI REGTEALTLA AKPDSLESKA CEKWKRPFRS ASATSLTLSC CVDVVKGLLD
FKKRRGHSIG GVPEQQYQSI PICVAAKLPV QALDVLDAHL SEVNAVHFGP NSNLLATGGA
DRLIHLWNIV GGRLEANQTL EGAGGSITSV DIDPSGSQVL AATYNQAAQL WKVGEAHSKE
TLSGHKDKVT AAKFKLTRHQ AVTGSRDRTV KEWDLGRAYC SRTINVLSYC NDVVCGDHII
ISGHNDQKIR FWDSRGPCCT QVIPVQGRVT SLSLSNDQLN LLSCSRDDTL KVIDLRVSNV
RQVFRADGFK CGSDWTKAVF SPDRRYALAG SWDGALYIWD VDTGKLESTL QGPHCVAVNA
VAWCCSGSHV VSVDQGRKVV LWH
//
