ID G5ASB1_HETGA Unreviewed; 476 AA.
AC G5ASB1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Neuronal calcium sensor 1 {ECO:0000256|ARBA:ARBA00039972};
DE AltName: Full=Frequenin homolog {ECO:0000256|ARBA:ARBA00042385};
GN ORFNames=GW7_01881 {ECO:0000313|EMBL:EHA99921.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA99921.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA99921.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
CC -!- SIMILARITY: Belongs to the recoverin family.
CC {ECO:0000256|ARBA:ARBA00006049}.
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DR EMBL; JH166728; EHA99921.1; -; Genomic_DNA.
DR AlphaFoldDB; G5ASB1; -.
DR STRING; 10181.G5ASB1; -.
DR eggNOG; KOG0044; Eukaryota.
DR InParanoid; G5ASB1; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR028846; Recoverin.
DR PANTHER; PTHR23055; CALCIUM BINDING PROTEINS; 1.
DR PANTHER; PTHR23055:SF195; NEURONAL CALCIUM SENSOR 1; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 3.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 109..144
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 145..180
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 193..228
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 286..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 476 AA; 51248 MW; 5D87CEF29DCCD549 CRC64;
MSPEDPLSSG MGMRGPDWED QAWLFDQEGA VALGGPPGPL HRRGGVGGWG VDGALDPAPA
PTPAAFPQPA VTEKEVQQWY KGFIKDCPSG QLDAAGFQKI YKQFFPFGDP TKFATFVFNV
FDENKDGRIE FSEFIQALSV TSRGTLDEKL RWAFKLYDLD NDGYITRNEM LDIVDAIYQM
VGNTVELPEE ENTPEKRVDR IFAMMDKNAD GKLTLQEFQE GSKADPSIVQ ALSLYDGLTP
GNTSPLPCRE ASAARRHPCA RPAVRIHAPP AAPGPRGPAL LTLARACPPP DVTSSSRRPP
PLSRTRKGCS PLQNPGLCSG CCGLSSLLLA CQNGSDPDTL VTQGIPGPGH TSAPGQPDWW
LVSLLPTSCG RGVGDPVLAC SVHSFSIRAV EMTVHFSQLW GPQRDELCPS LCRFLCPRVV
VQLRDSSEIP SDPPDVSGSR LAFLYSSPGL GGEPGKAYTA LEVLTSGPHL SLPLQQ
//
