ID G5ASP1_HETGA Unreviewed; 471 AA.
AC G5ASP1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Heat shock factor protein 3 {ECO:0000313|EMBL:EHB00052.1};
GN ORFNames=GW7_08566 {ECO:0000313|EMBL:EHB00052.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB00052.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB00052.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|ARBA:ARBA00006403,
CC ECO:0000256|RuleBase:RU004020}.
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DR EMBL; JH166749; EHB00052.1; -; Genomic_DNA.
DR AlphaFoldDB; G5ASP1; -.
DR STRING; 10181.G5ASP1; -.
DR Ensembl; ENSHGLT00000054005; ENSHGLP00000032620; ENSHGLG00000007957.
DR Ensembl; ENSHGLT00100064115; ENSHGLP00100032906; ENSHGLG00100012846.
DR InParanoid; G5ASP1; -.
DR OMA; GECKLFP; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015:SF148; HEAT SHOCK FACTOR PROTEIN 3; 1.
DR PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Stress response {ECO:0000313|EMBL:EHB00052.1}.
FT DOMAIN 8..111
FT /note="HSF-type DNA-binding"
FT /evidence="ECO:0000259|SMART:SM00415"
SQ SEQUENCE 471 AA; 53250 MW; FA47F50F6B9A7DAA CRC64;
MEEASTAVVP SFLVKLWAIV DNTDLDNVIR WSENGQSFCI INEQIFAKTV LPKYFKHSNI
ASFTRQLNIY GFRKVIGLAL EKTGPNASAV EFQHPLFKKG GKSFLENIKR KVPSEKMQHV
KISNEMHRMM TEVQEMNNKQ NNMDAKFEKL KKSLPVISEV SASKCARPYF HIPEEKEKEA
MEILKDGYAL IEDKYKNLLD SDLPTLKDEY KNLVSSVDQT NEDHGKDPKM SSQDVPMCED
SVITDLSLAI PDLQDLMTVE SFVQETKDIS LELESLLSQD IDSVLTEDKS DIQCDTTMNR
DEMNYISGDL MELKSPLYKK NVNYSSDHAS EPVSFELLNL MTNENETLLN VHVMAETDNL
SLMKNQEGEI SLLDASGKEG EMLMNDFGGL QDSSDLYLDD LKNSSNVLPN LCDHDYISVN
IPSQQYVANP TENVMPYLCM ETSGECKLFP FLLPNSGTNF VEEATKIDPS T
//
