ID G5AUY6_HETGA Unreviewed; 320 AA.
AC G5AUY6;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=RNA-binding protein Nova-2 {ECO:0000313|EMBL:EHB00847.1};
GN ORFNames=GW7_18111 {ECO:0000313|EMBL:EHB00847.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB00847.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB00847.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBUNIT: Interacts with PTBP2; the interaction is direct.
CC {ECO:0000256|ARBA:ARBA00034798}.
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DR EMBL; JH167046; EHB00847.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AUY6; -.
DR eggNOG; KOG2191; Eukaryota.
DR InParanoid; G5AUY6; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22435; KH-I_NOVA_rpt1; 1.
DR CDD; cd22436; KH-I_NOVA_rpt2; 1.
DR CDD; cd09031; KH-I_NOVA_rpt3; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 3.
DR InterPro; IPR047275; KH-I_NOVA_rpt1.
DR InterPro; IPR047276; KH-I_NOVA_rpt2.
DR InterPro; IPR047274; KH-I_NOVA_rpt3.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR PANTHER; PTHR10288:SF162; RNA-BINDING PROTEIN NOVA-2; 1.
DR Pfam; PF00013; KH_1; 3.
DR SMART; SM00322; KH; 3.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 3.
DR PROSITE; PS50084; KH_TYPE_1; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}.
FT DOMAIN 24..97
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 122..194
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 198..271
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
SQ SEQUENCE 320 AA; 34508 MW; 064BE00F11D14376 CRC64;
MEGKGFRSMF ETLKGVHVTR EEEGEYFLKV LIPSYAAGSI IGKGGQTIVQ LQKETGATIK
LSKSKDFYPG TTERVCLVQG TAEALNAVHS FIAEKVREIP QAMTKPEVVN ILQPQTTMNP
DRAKQAKLIV PNSTAGLIIG KGGATVKAVM EQSGAWVQLS QKPEGINLQE RVVTVSGEPE
QVHKAVSAIV QKLAAESAKE LVEIAVPENL VGAILGKGGK TLVEYQELTG ARIQISKKGE
FLPGTRNRRV TITGSPAATQ AAQYLISQRV TYEQGVFQTL LFSMALGESG LLLVSFLKKE
GRKATETIPT PKAWEAPTLH
//
