ID G5AW78_HETGA Unreviewed; 2253 AA.
AC G5AW78;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Myosin-VIIa {ECO:0000313|EMBL:EHB01289.1};
GN ORFNames=GW7_00926 {ECO:0000313|EMBL:EHB01289.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB01289.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB01289.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; JH167263; EHB01289.1; -; Genomic_DNA.
DR STRING; 10181.G5AW78; -.
DR eggNOG; KOG4229; Eukaryota.
DR InParanoid; G5AW78; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR CDD; cd22249; UDM1_RNF168_RNF169-like; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF34; MYOSIN VIIA; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 97..812
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1088..1324
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1329..1638
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1636..1705
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1780..1934
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1940..2243
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 689..711
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 938..1006
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 190..197
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2253 AA; 259106 MW; 2DD19E6050896039 CRC64;
MEPPGRPADP GEERALQPGK WALVRSLNQA LKTFAVLRGD YVWMDLRSGQ EFDVPIGAVV
KLCDSGQIQV VDDEGNEHWI SPQNATHIKP MHPTSIHGVE DMIRLGDLNE AGILRNLLIR
YRDHLIYTYT GSILVAVNPY QLLSIYSPEH IRQYTNKKIG EMPPHIFAIA DNCYFNMKRN
SRDQCCIISG ESGAGKTEST KLILQFLAAI SGQHSWIEQQ VLEATPILEA FGNAKTIRND
NSSRFGKYID IHFNKRGAIE GAKIEQYLLE KSRVCRQAPD ERNYHVFYCM LEGMSKEQKK
KLGLGQATDY NYLAMGNCTT CEGRVDSQEY ANIRSAMKVL MFTDTENWEI SKLLAAILHL
GNLQYEARTF ENLDACEVLF SPSLATAASL LEVNPPDLMS CLTSRTLITR GETVSTPLSR
EQALDVRDAF VKVNPPDLMS CLTSRTLITR GETVSTPLSR EQALDVRDAF VRGIYGRLFV
WIVEKINAAI YKPPSQEVNS RRSIGLLDIF GFENFAVNSF EQLCINFANE HLQQFFVRHV
FKLEQEEYDL ESIDWLHIEF TDNQDALDMI ANKPMNIISL IDEESKFPKG TDTTMLHKLN
SQHKLNANYV PPKNNHETQF GINHFAGVVY YETQGFLEKN RDTLHGDIIQ LVHSSRNKFI
KQIFQADVAM GAETRKRSPT LSSQFKRSLE LLMRTLGACQ PFFVRCIKPN EFKKPMLFDR
HLCVRQLRYS GMMETIRIRR AGYPIRYSFV EFVERYRVLL PGVKPAYKQG DLRGTCQRIA
EAVLGTHDDW QIGKTKIFLK DHHDMLLEVE RDKAITDRVI LLQKVIRGFK DRSNFLKLKN
AATLIQRHWR GRNCRRSYEL MRLGFLRLQA LHHSRKLHQQ YRLARRHIIE FQARCRAYLV
RKAFRHRLWA VLTVQAYARG MIARRLHRRL KGEYLRRLEA EKMRLAEEEK LRKEMSAKKA
KEEAERKHQE RLAQLAREDA ERELKEKEEA RQKKELLERM ERARHQPINH SDMVDKMFGF
LGTSGGLPGQ EGQAPSGFED LEQGRREMVE EDLDAALPLP DEDEEDLSEY KFAKFAATYF
QGTTTHSYTR RPLKQPLLYH DDEGDQLAAL AVWITILRFM GDLPEPKYHT AMSDGSEKIP
VMTKIYETLG KKTYKRELQA LQGEGEAQLP EGQKKSSVRH KLVHLTLKKK SKLTEEVTKR
LHDGESTVQG NSMLEDRPTS NLEKLHFIIG NGILRPALRD EIYCQISKQL THNPSKSSYA
RGWILVSLCV GCFAPSEKFV KYLRNFIHGG PPGYAPYCEE RLRRTFVNGT RTQPPSWLEL
QATKSKKPIM LPVTFMDGTT KTLLTDSATT AKELCNALAD KISLRDRFGF SLYIALFDKV
SSLGSGSDHV MDAISQCEQY AKEQGAQERN APWRLFFRKE VFTPWHNSSE DNVATNLIYQ
QVVRGVKFGE YRCEKEDDLA ELASQQYFVD YGSEMILERL LNLVPTYIPD REITPLKTLE
KWAQLAIAAH KKGIYAQRRT DAQKVKEDVV NYARFKWPLL FSRFYEVYKF SGPTLPKNDV
IVAVNWTGVY FVDEQEQVLL ELSFPEIMAV SSSRGAKLTA PSFTLATIKG DEYTFTSSNA
EDIRDLVVTF LEGLRKRSKY VVALQDNSNP VGEESGFLSF AKGDLIILDH DTGEQVMNSG
WANGINERTK QRGDFPTDCV YVMPTVTMPP REIVALVTMT PDQRQDVIRL LQLHTVEPEV
RSKPYTLEEF SYDYFRPPPK HTLSRVMVSK ARGKDRLWSH TREPLKQALL KKILGSEELS
QEACMAFIDI HTSTVLKYMG DYPSKRARSV NELTDQIFEG ALKAEPLKDE AYVQILKQLT
DNHIRYSEER GWELLWLCTG LFPPSNILLP HVQRFLQSRK HCPLAIDCLQ RLQKALRNGS
RKYPPHLVEV EAIQHKTTQI FHKVYFPDDT DEAFEVESST KAKDFCQNIA TRLLLKSSEG
FSLFVKIADK VISVPENDFF FDFVRHLTDW IKKARPIKDG ILPSLTYQVF FMKKLWTTTV
PGKDPMADSI FHYYQELPKY LRGYHKCTRE EVLQLGALIY RVKFEEDKSY FPSIPKLLRE
LVPQDLIRQI SPDDWKRSIV AYFNKHTGKS KEEAKLAFLK LIFKWPTFGS AFFEVKQTTE
PNFPEILLIA INKYGVSLID PRTKDILTTH PFTKISNWSS GNTYFHITIG NLVRGSKLLC
ETSLGYKMDD LLTSYISQML TAMSKQRGSR SGK
//
