ID G5AWX1_HETGA Unreviewed; 288 AA.
AC G5AWX1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Malectin {ECO:0000313|EMBL:EHB01532.1};
GN ORFNames=GW7_02120 {ECO:0000313|EMBL:EHB01532.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB01532.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB01532.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}.
CC -!- SIMILARITY: Belongs to the malectin family.
CC {ECO:0000256|ARBA:ARBA00009141}.
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DR EMBL; JH167282; EHB01532.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AWX1; -.
DR STRING; 10181.G5AWX1; -.
DR eggNOG; KOG3593; Eukaryota.
DR InParanoid; G5AWX1; -.
DR OMA; PNPYSMD; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.430; Galactose-binding lectin; 1.
DR InterPro; IPR021720; Malectin_dom.
DR InterPro; IPR039155; MLEC.
DR PANTHER; PTHR13460:SF0; MALECTIN; 1.
DR PANTHER; PTHR13460; UNCHARACTERIZED; 1.
DR Pfam; PF11721; Malectin; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..288
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003473775"
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..204
FT /note="Malectin"
FT /evidence="ECO:0000259|Pfam:PF11721"
FT REGION 217..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 288 AA; 32071 MW; BF17AE3398E369AF CRC64;
MLGPQALERA AVALLRLLLL LLPALREPGL GVPGAAGAGL PESVIWAVNA GGEAHVDVHG
IHFRKDPLEG RVGRASDYGM KLPILRSNPE DQILYQTERY NEETFGYEVP IKEEGDYVLV
LKFAEVYFAQ SQQKVFDVRL NGHVVVKDLD IFDRVGHSTA HDEIIPMSIR KGKLSVQGEV
STFTGKLYIE FVKGYYDNPK VCALYIMAGT VDDVPKLQPH PGLEKKEEEE EEEEYDEGSN
PKRQTNKNRV QSGPRTPNPY ASDNSSLMFP ILVAFGVFIP TLFCLCRL
//
